Impact of Molecular Building Blocks on Dynamic Nature of Novel Biomimetic Drug Delivery Systems as Ufasomes and Ufosomes: Modification in Structure and Surface Charge

Abstract

This review is focused on the self-assembly of different molecular building blocks at various levels of complexity. In this perspective, we present the basic concept and recent research on the self-assembly of fatty acids and their derivatives, surfactants, and cholesterol. In addition, we discuss the conditions for designing and stabilizing novel vesicular drug delivery systems and how the flux changes due to the molecular structure of building blocks. Furthermore, the article provides a brief discussion on fatty acid and oleate self-assembly, which is becoming an emerging nanotechnology because of its ability to alter the dynamic nature of the skin. These structures have been shown to enhance the skin permeability of drugs and other active compounds, making them potential candidates for transdermal drug delivery. In conclusion, the self-assembly of various molecular building blocks at different levels of complexity has significant implications in the fields of drug delivery, cosmetics, and nanotechnology. The ability to control and manipulate the self-assembly process offers a wide range of possibilities for the design of novel and efficient drug delivery systems.