Utkarsh Raj, S. Rai, S. Mathur, A. Saxena, A. Kaushik
{"title":"A comprehensive study on SARS-CoV-2 Through Gene Expression Meta-Analysis and Network Biology Approach","authors":"Utkarsh Raj, S. Rai, S. Mathur, A. Saxena, A. Kaushik","doi":"10.30491/jabr.2021.275694.1360","DOIUrl":null,"url":null,"abstract":"Introduction: Coronaviruses are significant pathogens of both human and animals and are globally distributed. Out of seven CoVs strains, the most lethal coronavirus strains being portrayed is SARS-CoV-2. It can cause bronchial asthma, and severe pneumonia and acute respiratory disease. Due to its contagion in infants, adults, and immunocompromised patients which further results in making this a deadly disease, thus there is an urgent need to develop effective and safe therapeutics against it.Materials and Methods: Meta-analysis of publicly available gene expression datasets belonging to SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E were carried out to identify the potential differentially expressed genes exclusively associated with SARS-CoV-2, and then a network model was developed to decipher significant drug targets, associated pathways and drug candidates which can be repurposed for this infection.Results: The COVID-19 infection mainly targets immune responses and regulatory processes. A novel role of Relaxin signaling pathway was identified in SARS-CoV-2 infection. Anti-inflammatory, anti-tumor, nutraceutical and anthelmintic agents were found to be good prospective candidates for repurposing against COVID-19.Conclusions: This theoretical study resulted in the identification of approved drug targets that may have the potential to be repurposed for COVID 19 treatment.","PeriodicalId":14945,"journal":{"name":"Journal of Applied Biotechnology Reports","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Biotechnology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30491/jabr.2021.275694.1360","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Coronaviruses are significant pathogens of both human and animals and are globally distributed. Out of seven CoVs strains, the most lethal coronavirus strains being portrayed is SARS-CoV-2. It can cause bronchial asthma, and severe pneumonia and acute respiratory disease. Due to its contagion in infants, adults, and immunocompromised patients which further results in making this a deadly disease, thus there is an urgent need to develop effective and safe therapeutics against it.Materials and Methods: Meta-analysis of publicly available gene expression datasets belonging to SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E were carried out to identify the potential differentially expressed genes exclusively associated with SARS-CoV-2, and then a network model was developed to decipher significant drug targets, associated pathways and drug candidates which can be repurposed for this infection.Results: The COVID-19 infection mainly targets immune responses and regulatory processes. A novel role of Relaxin signaling pathway was identified in SARS-CoV-2 infection. Anti-inflammatory, anti-tumor, nutraceutical and anthelmintic agents were found to be good prospective candidates for repurposing against COVID-19.Conclusions: This theoretical study resulted in the identification of approved drug targets that may have the potential to be repurposed for COVID 19 treatment.
期刊介绍:
The Journal of Applied Biotechnology Reports (JABR) publishes papers describing experimental work relating to all fundamental issues of biotechnology including: Cell Biology, Genetics, Microbiology, Immunology, Molecular Biology, Biochemistry, Embryology, Immunogenetics, Cell and Tissue Culture, Molecular Ecology, Genetic Engineering and Biological Engineering, Bioremediation and Biodegradation, Bioinformatics, Biotechnology Regulations, Pharmacogenomics, Gene Therapy, Plant, Animal, Microbial and Environmental Biotechnology, Nanobiotechnology, Medical Biotechnology, Biosafety, Biosecurity, Bioenergy, Biomass, Biomaterials and Biobased Chemicals and Enzymes. Journal of Applied Biotechnology Reports promotes a special emphasis on: -Improvement methods in biotechnology -Optimization process for high production in fermentor systems -Protein and enzyme engineering -Antibody engineering and monoclonal antibody -Molecular farming -Bioremediation -Immobilizing methods -biocatalysis