{"title":"Physalin A Enhances Autophagy and Suppresses Oxidative Stress Injury and Extracellular Matrix Deposition in Diabetic Nephropathy","authors":"Miao Zhang, Dan-dan Huang, Dan Chen, Taotao Hu","doi":"10.37290/ctnr2641-452x.21:131-137","DOIUrl":null,"url":null,"abstract":"Diabetic nephropathy is the major cause of chronic kidney disease worldwide. Persistent hyperglycemia plays a causative role in diabetic nephropathy. Physalin A, a steroidal plant-derived bioactive compound known to exhibit anti-inflammatory, anti-tumor, anti-fungal, and analgesic activities, has been widely used in traditional Chinese medicine practice. The present study examined the effect of Physalin A on high-glucose-treated HBZY-1 cells, a cell culture model of diabetic nephropathy. The results show that Physalin A alleviated cell proliferation, oxidative stress, extracellular matrix protein deposition, and insufficient autophagy induced by high glucose through inhibiting the mitogen-activated protein kinase pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Topics in Nutraceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.37290/ctnr2641-452x.21:131-137","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetic nephropathy is the major cause of chronic kidney disease worldwide. Persistent hyperglycemia plays a causative role in diabetic nephropathy. Physalin A, a steroidal plant-derived bioactive compound known to exhibit anti-inflammatory, anti-tumor, anti-fungal, and analgesic activities, has been widely used in traditional Chinese medicine practice. The present study examined the effect of Physalin A on high-glucose-treated HBZY-1 cells, a cell culture model of diabetic nephropathy. The results show that Physalin A alleviated cell proliferation, oxidative stress, extracellular matrix protein deposition, and insufficient autophagy induced by high glucose through inhibiting the mitogen-activated protein kinase pathway.
期刊介绍：
Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products.
To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine.
The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.
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