Pub Date : 2023-10-19DOI: 10.37290/ctnr2641-452x.21:502-508
Huimin Li
We have compared the effect of stress adaptation theory-based nursing care with routine nursing care on the nutritional status and gastrointestinal motility of preterm infants. The results show an improvement in fetal growth and development after delivery, the physiological and neurological functions of babies, an increase in head circumference, body length, and weight and gastrointestinal function after stress adaptation theory-based nursing care (P < 0.05). However, there was no evidence for an intergroup difference in the incidence of adverse reactions (P > 0.05). These results suggest that stress adaptation theory-based nursing care is conducive to enhancing the nutritional status and gastrointestinal function of preterm infants and ensuring their healthy growth.
{"title":"Effect of Individualized Nursing Based on Stress Adaptation Theory on Nutritional Status and Gastrointestinal Motility of Preterm Infants","authors":"Huimin Li","doi":"10.37290/ctnr2641-452x.21:502-508","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:502-508","url":null,"abstract":"We have compared the effect of stress adaptation theory-based nursing care with routine nursing care on the nutritional status and gastrointestinal motility of preterm infants. The results show an improvement in fetal growth and development after delivery, the physiological and neurological functions of babies, an increase in head circumference, body length, and weight and gastrointestinal function after stress adaptation theory-based nursing care (P < 0.05). However, there was no evidence for an intergroup difference in the incidence of adverse reactions (P > 0.05). These results suggest that stress adaptation theory-based nursing care is conducive to enhancing the nutritional status and gastrointestinal function of preterm infants and ensuring their healthy growth.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"57 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:326-331
S. Zheng, D.W. Liu
This manuscript compares the effects of Rhodiola rosea, red goji berry, and Siraitia grosvenorii on the recovery of physical strength in athletes after aerobic exercise. Subjects were compared for the effects of different treatments on changes in physiological (heart rate, rating of perceived exertion, and vertical jump-and-reach performance) and biochemical (blood lactic acid, creatine kinase, and blood urea nitrogen) markers after four weeks of aerobic exercise. After four weeks of aerobic exercise, the heart rate of all groups of athletes increased rapidly, the level of fatigue deepened, the vertical jump-andreach performance decreased, and the levels of blood lactic acid, creatine kinase, and blood urea nitrogen all increased to varying degrees. At the 12th minute after exercise, the heart rate of the Rhodiola rosea group, the red goji berry group, and the Siraitia grosvenorii group recovered faster, the RPE value was lower, and the vertical jump-and-reach performance was better compared with the control, P < 0.05; moreover, the levels of all three biochemical markers were all significantly lower than those of the control group. In conclusion, the intake of these nutrients can promote the recovery of physical strength in athletes, accelerate the clearance of blood lactate, and inhibit the generation of creatine kinase and blood urea nitrogen. Therefore, they can be used as nutritional support for athletes during aerobic exercise.
{"title":"Comparing Efficacy of Rhodiola Rosea, Red Goji Berry, and Siraitia Grosvenorii in Physical Recovery After Aerobic Exercise","authors":"S. Zheng, D.W. Liu","doi":"10.37290/ctnr2641-452x.21:326-331","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:326-331","url":null,"abstract":"This manuscript compares the effects of Rhodiola rosea, red goji berry, and Siraitia grosvenorii on the recovery of physical strength in athletes after aerobic exercise. Subjects were compared for the effects of different treatments on changes in physiological (heart rate, rating of perceived exertion, and vertical jump-and-reach performance) and biochemical (blood lactic acid, creatine kinase, and blood urea nitrogen) markers after four weeks of aerobic exercise. After four weeks of aerobic exercise, the heart rate of all groups of athletes increased rapidly, the level of fatigue deepened, the vertical jump-andreach performance decreased, and the levels of blood lactic acid, creatine kinase, and blood urea nitrogen all increased to varying degrees. At the 12th minute after exercise, the heart rate of the Rhodiola rosea group, the red goji berry group, and the Siraitia grosvenorii group recovered faster, the RPE value was lower, and the vertical jump-and-reach performance was better compared with the control, P < 0.05; moreover, the levels of all three biochemical markers were all significantly lower than those of the control group. In conclusion, the intake of these nutrients can promote the recovery of physical strength in athletes, accelerate the clearance of blood lactate, and inhibit the generation of creatine kinase and blood urea nitrogen. Therefore, they can be used as nutritional support for athletes during aerobic exercise.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47475573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We have examined the effect of added elemene on the clinical efficacy of combined treatment of advanced hepatocellular carcinoma with lenvatinib and tislelizumab chemotherapy. Patients with advanced hepatocellular carcinoma (n = 150) were divided into groups of equal size and treated with the multi-kinase inhibitor lenvatinib plus the PD-1 inhibitor tislelizumab alone (control) or along with elemene (treatment), a plant sesquiterpene with antiproliferative effects. The results of the study show a higher objective response rate and local control rate, superior post-treatment liver function, immune function, anti-angiogenesis capacity, and better quality of life, as reflected by higher functional assessment of cancer therapy scores (P < 0.05). Additionally, after treatment, albumin and prealbumin were elevated, and patient-generated subjective global assessment scores declined in both groups after treatment, but no difference was found between the two groups (P > 0.05). To sum up, elemene added to lenvatinib and tislelizumab chemotherapy is effective in treating advanced hepatocellular carcinoma patients and is recommended for clinical use.
{"title":"Elemene Promotes Clinical Efficacy of Multiple Kinase Inhibitor Lenvatinib and Programmed Death-1 Inhibitor Tislelizumab Combination in Advanced Hepatocellular Carcinoma","authors":"Jie Duan, Wei Chen, Changhao Chen, Fangnan Song, Faxi Chen, Fangfang Jiang, Huiwen Xing, Aidong Gu","doi":"10.37290/ctnr2641-452x.21:386-394","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:386-394","url":null,"abstract":"We have examined the effect of added elemene on the clinical efficacy of combined treatment of advanced hepatocellular carcinoma with lenvatinib and tislelizumab chemotherapy. Patients with advanced hepatocellular carcinoma (n = 150) were divided into groups of equal size and treated with the multi-kinase inhibitor lenvatinib plus the PD-1 inhibitor tislelizumab alone (control) or along with elemene (treatment), a plant sesquiterpene with antiproliferative effects. The results of the study show a higher objective response rate and local control rate, superior post-treatment liver function, immune function, anti-angiogenesis capacity, and better quality of life, as reflected by higher functional assessment of cancer therapy scores (P < 0.05). Additionally, after treatment, albumin and prealbumin were elevated, and patient-generated subjective global assessment scores declined in both groups after treatment, but no difference was found between the two groups (P > 0.05). To sum up, elemene added to lenvatinib and tislelizumab chemotherapy is effective in treating advanced hepatocellular carcinoma patients and is recommended for clinical use.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:373-379
Hans Hsientsai Wu, Jian-Jung Chen, Yi-Chuan Chen, Bagus Haryadi
This study aimed at identifying middle-aged subjects at risk for developing type 2 diabetes mellitus using noninvasive skin carotenoid and vascular function measurements. To this end, 61 subjects (40–65 years of age) without type 2 diabetes mellitus (Group A, Hemoglobin A1c < 6.5%) and 69 subjects (40–65 years of age) with type 2 diabetes mellitus (Group B, Hemoglobin A1c ≥ 6.5%) were recruited (Table 1). The skin carotenoid score was recorded using spectroscopy-based skin carotenoid measurements that approximate dietary fruit and vegetable intake. Endothelial function and heart rate variability were measured for the two groups and correlated with skin carotenoids scores. The daily vegetable and fruit intake was positively correlated with the skin carotenoids score in both groups (Group A, r = 0.598, p < 0.001; Group B, r = 0.449, p < 0.001). There were also significant differences in skin carotenoids score, indices of endothelial function, and heart rate variability between the subjects in group A and group B. There was a negative correlation between skin carotenoids score and individual determinants of metabolic syndrome, including high-density lipoprotein (r = −0.361, p = 0.009), waist circumference (r = −0.450, p < 0.001), fasting blood sugar (r = −0.713, p < 0.001), and Hemoglobin A1c (r = −0.808, p < 0.001); however, systolic blood pressure showed no significant correlation (p = 0.06). In conclusion, carotenoids and cardiovascular parameters are reliable predictive factors of type 2 diabetes mellitus in middle-aged subjects.
本研究旨在通过无创皮肤类胡萝卜素和血管功能测量来识别有患2型糖尿病风险的中年受试者。为此，61名受试者(40-65岁)无2型糖尿病(A组，血红蛋白A1c <6.5%)和69名2型糖尿病患者(B组，血红蛋白A1c≥6.5%)(40-65岁)被招募(表1)。皮肤类胡萝卜素评分采用基于光谱的皮肤类胡萝卜素测量方法记录，近似于饮食中的水果和蔬菜摄入量。测量了两组的内皮功能和心率变异性，并与皮肤类胡萝卜素评分相关。两组每日蔬菜和水果摄入量与皮肤类胡萝卜素得分呈正相关(A组，r = 0.598, p <0.001;B组，r = 0.449, p <0.001)。A组和b组受试者在皮肤类胡萝卜素评分、内皮功能指数和心率变异性方面也存在显著差异。皮肤类胡萝卜素评分与代谢综合征的个体决定因素呈负相关，包括高密度脂蛋白(r = - 0.361, p = 0.009)、腰围(r = - 0.450, p <0.001)，空腹血糖(r = - 0.713, p <0.001)，血红蛋白A1c (r = - 0.808, p <0.001);而收缩压无显著相关性(p = 0.06)。综上所述，类胡萝卜素和心血管参数是中年人2型糖尿病的可靠预测因素。
{"title":"Skin Carotenoid Score as an Important Prognostic Factor for Predicting Type 2 Diabetes Mellitus in Middle-Aged Subjects","authors":"Hans Hsientsai Wu, Jian-Jung Chen, Yi-Chuan Chen, Bagus Haryadi","doi":"10.37290/ctnr2641-452x.21:373-379","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:373-379","url":null,"abstract":"This study aimed at identifying middle-aged subjects at risk for developing type 2 diabetes mellitus using noninvasive skin carotenoid and vascular function measurements. To this end, 61 subjects (40–65 years of age) without type 2 diabetes mellitus (Group A, Hemoglobin A1c < 6.5%) and 69 subjects (40–65 years of age) with type 2 diabetes mellitus (Group B, Hemoglobin A1c ≥ 6.5%) were recruited (Table 1). The skin carotenoid score was recorded using spectroscopy-based skin carotenoid measurements that approximate dietary fruit and vegetable intake. Endothelial function and heart rate variability were measured for the two groups and correlated with skin carotenoids scores. The daily vegetable and fruit intake was positively correlated with the skin carotenoids score in both groups (Group A, r = 0.598, p < 0.001; Group B, r = 0.449, p < 0.001). There were also significant differences in skin carotenoids score, indices of endothelial function, and heart rate variability between the subjects in group A and group B. There was a negative correlation between skin carotenoids score and individual determinants of metabolic syndrome, including high-density lipoprotein (r = −0.361, p = 0.009), waist circumference (r = −0.450, p < 0.001), fasting blood sugar (r = −0.713, p < 0.001), and Hemoglobin A1c (r = −0.808, p < 0.001); however, systolic blood pressure showed no significant correlation (p = 0.06). In conclusion, carotenoids and cardiovascular parameters are reliable predictive factors of type 2 diabetes mellitus in middle-aged subjects.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:368-372
Miao Li, Pengchong Di, Kun Liu, Ting Gao, Mingkun Wu, Kejuan Sun
The influence of dietary fiber enteral nutrition support on promoting the recovery of intestinal function in patients who underwent gynecological laparoscopic surgery was investigated. To this end, patients were given dietary fiber (treatment group) or nondietary (control group) fiber enteral nutrition support after surgery, and the recovery time of bowel sounds, the time of first anal exhaustion, and defecation between the two groups were compared. After surgery, the recovery time of bowel sounds, the time of first anal exhaust and defecation in the treatment group were shorter than the control group (P < 0.05). Serum D-lactic acid, diamine oxidase, c-reactive protein, interleukin-6, tumor necrosis factor-α, and procalcitonin levels in the treatment group were lower than those in the control group (P < 0.05). However, albumin, pre-albumin, and transferrin levels in the treatment group were higher than those in the control group (P < 0.05). The occurrence of postoperative intestinal complications in the treatment group was lower relative to the control group (P < 0.05). To sum up, enteral nutrition containing dietary fiber can improve the intestinal barrier function and nutritional status of patients undergoing gynecological laparoscopic surgery, reduce the inflammatory response, and accelerate the recovery of gastrointestinal function.
{"title":"Dietary Fiber Enteral Nutrition Accelerates Recovery Patients Undergoing Gynecological Laparoscopic Surgery","authors":"Miao Li, Pengchong Di, Kun Liu, Ting Gao, Mingkun Wu, Kejuan Sun","doi":"10.37290/ctnr2641-452x.21:368-372","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:368-372","url":null,"abstract":"The influence of dietary fiber enteral nutrition support on promoting the recovery of intestinal function in patients who underwent gynecological laparoscopic surgery was investigated. To this end, patients were given dietary fiber (treatment group) or nondietary (control group) fiber enteral nutrition support after surgery, and the recovery time of bowel sounds, the time of first anal exhaustion, and defecation between the two groups were compared. After surgery, the recovery time of bowel sounds, the time of first anal exhaust and defecation in the treatment group were shorter than the control group (P < 0.05). Serum D-lactic acid, diamine oxidase, c-reactive protein, interleukin-6, tumor necrosis factor-α, and procalcitonin levels in the treatment group were lower than those in the control group (P < 0.05). However, albumin, pre-albumin, and transferrin levels in the treatment group were higher than those in the control group (P < 0.05). The occurrence of postoperative intestinal complications in the treatment group was lower relative to the control group (P < 0.05). To sum up, enteral nutrition containing dietary fiber can improve the intestinal barrier function and nutritional status of patients undergoing gynecological laparoscopic surgery, reduce the inflammatory response, and accelerate the recovery of gastrointestinal function.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:361-367
Ya Zhang, Jinglin Wu, Yanan Gao, Fang Ge
To investigate the role of the Internet-based and health care cluster model in the nutritional management of infertile patients with polycystic ovary syndrome, we compared the body mass index, insulin resistance index, serum testosterone level, anxiety level, depression level, and disease-related quality of life status of the control group with those receiving regular healthy lifestyle guidance and management. Lifestyle management was carried out through assessment, screening, status analysis, setting body mass management goals, diet management, exercise management, behavior management, and health guidance. After the intervention, the body mass index, insulin resistance index, and serum testosterone levels of the intervention group were lower (P < 0.05) than those of the control group. The scores of the generalized anxiety scale and patient health questionnaire were lower than those of the control group; the scores of the revised patient survival quality scale were higher than those of the control group, and the differences were statistically significant (P < 0.05). The life nutrition management program based on the Internet and healthcare group model is beneficial in modifying the patients’ endocrine metabolic status, relieving anxiety and depression, and improving their quality of life.
{"title":"Nutritional Management of Infertility in Patients with Polycystic Ovary Syndrome","authors":"Ya Zhang, Jinglin Wu, Yanan Gao, Fang Ge","doi":"10.37290/ctnr2641-452x.21:361-367","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:361-367","url":null,"abstract":"To investigate the role of the Internet-based and health care cluster model in the nutritional management of infertile patients with polycystic ovary syndrome, we compared the body mass index, insulin resistance index, serum testosterone level, anxiety level, depression level, and disease-related quality of life status of the control group with those receiving regular healthy lifestyle guidance and management. Lifestyle management was carried out through assessment, screening, status analysis, setting body mass management goals, diet management, exercise management, behavior management, and health guidance. After the intervention, the body mass index, insulin resistance index, and serum testosterone levels of the intervention group were lower (P < 0.05) than those of the control group. The scores of the generalized anxiety scale and patient health questionnaire were lower than those of the control group; the scores of the revised patient survival quality scale were higher than those of the control group, and the differences were statistically significant (P < 0.05). The life nutrition management program based on the Internet and healthcare group model is beneficial in modifying the patients’ endocrine metabolic status, relieving anxiety and depression, and improving their quality of life.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"267 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:346-349
Nisansala Chandimali, Mirae Oh, Hyung-Jin Lim, Yeong-Seon Won, Seon-Gyeong Bak, Eun Hyun Park, Seung-Jae Lee
In this study, we have characterized the acid-pretreated gelatin extracted from duck skin by-products. To this end, we employed two-dimensional gel electrophoresis to validate the size of gelatin (72 kDa) and scanning electron microscopy to examine the surface characteristics of gelatin. We next examined the antioxidant activity of acid-pretreated gelatin extracted from duck skin by three-dimensional imaging using electronic spin resonance. The results show Alkyl, 1,1-diphenyl-2-picrylhydrazyl, and hydroxyl radical scavenging capabilities of acid-pretreated gelatin. We hope that these data will help expand the industrial application of duck-skin-derived gelatin.
{"title":"Antioxidant Activity of Acid Pretreated Gelatin Extracted from Duck Skin By-Products","authors":"Nisansala Chandimali, Mirae Oh, Hyung-Jin Lim, Yeong-Seon Won, Seon-Gyeong Bak, Eun Hyun Park, Seung-Jae Lee","doi":"10.37290/ctnr2641-452x.21:346-349","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:346-349","url":null,"abstract":"In this study, we have characterized the acid-pretreated gelatin extracted from duck skin by-products. To this end, we employed two-dimensional gel electrophoresis to validate the size of gelatin (72 kDa) and scanning electron microscopy to examine the surface characteristics of gelatin. We next examined the antioxidant activity of acid-pretreated gelatin extracted from duck skin by three-dimensional imaging using electronic spin resonance. The results show Alkyl, 1,1-diphenyl-2-picrylhydrazyl, and hydroxyl radical scavenging capabilities of acid-pretreated gelatin. We hope that these data will help expand the industrial application of duck-skin-derived gelatin.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:339-345
Ying Zhang, Li Lei, Zhimei Zeng
In periodontitis, increased endoplasmic reticulum stress followed by apoptosis and cell death in periodontal ligament cells further exacerbates periodontium destruction. Hispolon, a traditional Chinese medicine, could attenuate cell death induced by excessive oxidation. However, its role in oxidative stress and apoptosis in periodontitis is still unclear. To this end, the effect of the increasing dosage of hispolon on the reversal of the increase in cell viability caused by lipopolysaccharide in periodontal ligament cells in a periodontitis cell model was evaluated. The results show a dose-dependent hispolon promotion of cell viability in periodontal ligament cells. Cells treated with hispolon exhibited a decrease in cell apoptosis and a reduction in endoplasmic reticulum stress (Activating Transcription Factor 4, Glucose-Regulated Protein 78, and C/EBP-homologous protein) and inflammation (tumor necrosis factor-α, Interleukin-18, and Interleukin-6) levels than the lipopolysaccharide alone group. To further investigate the underlying mechanism(s), the relative expression of phosphorylation of extracellularly regulated protein kinases and phosphorylation of Jun N-terminal kinase in periodontal ligament cells were measured. The results show that hispolon attenuated lipopolysaccharide-induced inhibition of endoplasmic reticulum stress and apoptosis by deactivating the mitogen-activated protein kinase signaling pathway. In conclusion, hispolon reduces endoplasmic reticulum stress and alleviates apoptosis of periodontal ligament cells in periodontitis, and the protective mechanism is associated with the deactivation of the mitogen-activated protein kinase signaling pathway.
在牙周炎中，内质网应激的增加伴随着牙周韧带细胞的凋亡和细胞死亡，进一步加剧了牙周组织的破坏。中药Hispolon可减轻过度氧化引起的细胞死亡。然而，其在牙周炎氧化应激和细胞凋亡中的作用尚不清楚。为此，在牙周炎细胞模型中，我们评估了增加组蛋白的剂量对逆转脂多糖引起的牙周韧带细胞活力增加的影响。结果显示，组蛋白对牙周韧带细胞的活性有剂量依赖性的促进作用。与脂多糖单独处理组相比，组蛋白处理组细胞凋亡减少，内质网应激(激活转录因子4、葡萄糖调节蛋白78和C/ ebp同源蛋白)和炎症(肿瘤坏死因子-α、白细胞介素-18和白细胞介素-6)水平降低。为了进一步研究其潜在的机制，我们测量了牙周韧带细胞中细胞外调节蛋白激酶磷酸化和Jun n -末端激酶磷酸化的相对表达。结果表明，组蛋白蛋白通过使丝裂原激活的蛋白激酶信号通路失活，减轻了脂多糖诱导的内质网应激和细胞凋亡的抑制作用。综上所述，组蛋白蛋白可减轻牙周炎患者的内质网应激，减轻牙周韧带细胞凋亡，其保护机制可能与丝裂原激活的蛋白激酶信号通路失活有关。
{"title":"Hispolon Suppresses Endoplasmic Reticulum Stress and Apoptosis of Periodontal Ligament Cells in Periodontitis","authors":"Ying Zhang, Li Lei, Zhimei Zeng","doi":"10.37290/ctnr2641-452x.21:339-345","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:339-345","url":null,"abstract":"In periodontitis, increased endoplasmic reticulum stress followed by apoptosis and cell death in periodontal ligament cells further exacerbates periodontium destruction. Hispolon, a traditional Chinese medicine, could attenuate cell death induced by excessive oxidation. However, its role in oxidative stress and apoptosis in periodontitis is still unclear. To this end, the effect of the increasing dosage of hispolon on the reversal of the increase in cell viability caused by lipopolysaccharide in periodontal ligament cells in a periodontitis cell model was evaluated. The results show a dose-dependent hispolon promotion of cell viability in periodontal ligament cells. Cells treated with hispolon exhibited a decrease in cell apoptosis and a reduction in endoplasmic reticulum stress (Activating Transcription Factor 4, Glucose-Regulated Protein 78, and C/EBP-homologous protein) and inflammation (tumor necrosis factor-α, Interleukin-18, and Interleukin-6) levels than the lipopolysaccharide alone group. To further investigate the underlying mechanism(s), the relative expression of phosphorylation of extracellularly regulated protein kinases and phosphorylation of Jun N-terminal kinase in periodontal ligament cells were measured. The results show that hispolon attenuated lipopolysaccharide-induced inhibition of endoplasmic reticulum stress and apoptosis by deactivating the mitogen-activated protein kinase signaling pathway. In conclusion, hispolon reduces endoplasmic reticulum stress and alleviates apoptosis of periodontal ligament cells in periodontitis, and the protective mechanism is associated with the deactivation of the mitogen-activated protein kinase signaling pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69758170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:332-338
Ya Xu, Hong Zhang, Linlin Xu, Yang Sun, Chunlei Shi, W. Gao, Junwen Xu, K. Shao
We have investigated the role of Esculentoside A in the progression of carbapenem-resistant Klebsiella pneumoniae infection in Human MLE-12 cells. The results of the studies show that Esculentoside A enhances the viability of carbapenem-resistant Klebsiella pneumoniae-infected MLE-12 cells and suppresses cell apoptosis. EsA also suppresses mitochondrial damage and oxidative stress in lung epithelial cells caused by carbapenem-resistant Klebsiella pneumoniae infections. The data further confirmed that Esculentoside A could relieve mitochondrial damage, apoptosis, and oxidative stress in carbapenem-resistant Klebsiella pneumonia-infected lung epithelial cells by regulating the mitogen-activated protein kinase pathway.
{"title":"Esculentoside a Prevents Cell Damage Induced by Carbapenem-Resistant Klebsiella Pneumoniae Infection","authors":"Ya Xu, Hong Zhang, Linlin Xu, Yang Sun, Chunlei Shi, W. Gao, Junwen Xu, K. Shao","doi":"10.37290/ctnr2641-452x.21:332-338","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:332-338","url":null,"abstract":"We have investigated the role of Esculentoside A in the progression of carbapenem-resistant Klebsiella pneumoniae infection in Human MLE-12 cells. The results of the studies show that Esculentoside A enhances the viability of carbapenem-resistant Klebsiella pneumoniae-infected MLE-12 cells and suppresses cell apoptosis. EsA also suppresses mitochondrial damage and oxidative stress in lung epithelial cells caused by carbapenem-resistant Klebsiella pneumoniae infections. The data further confirmed that Esculentoside A could relieve mitochondrial damage, apoptosis, and oxidative stress in carbapenem-resistant Klebsiella pneumonia-infected lung epithelial cells by regulating the mitogen-activated protein kinase pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44521680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.37290/ctnr2641-452x.21:350-355
Li Chen, Xi Chen, Runwen Qi, Tao Zhang, Qiang Jiang, Jiaming Ye, Shaohong Zhang, Wen Zhou, Caiying Guo, Jiang Huang, Chao Liu
Type 2 diabetes often leads to compromised muscle endurance. Herein, we have explored the effect of Huanglian, a traditional Chinese medicine herb, on muscle endurance in patients with type 2 diabetes. To this end, type 2 diabetes patients aged 18–60 years were recruited and treated with anti-diabetic drugs, or anti-diabetic drugs plus 20 g of Huanglian daily, for one month. All subjects were instructed in muscle endurance assessment guided by the videos from the App in the clinic setting. The baseline and post-intervention muscle endurance values were recorded through the app and compared. The treatment group receiving Huanglian had higher muscle endurance than the control group. Multivariate regression analysis showed that lower limb muscle endurance (OR = 4.282, 95% CI: 1.537–11.928) and upper abdominal muscle endurance (OR = 4.632, 95% CI: 1.847–11.618) were correlated with Huanglian treatment. In conclusion, the level of muscle endurance of the lower limbs and upper abdominals is positively correlated with Huanglian decoction treatment in diabetic patients. The sensitivity of this video-guided test method is comparable to that of traditional equipment and more conducive to clinical application.
{"title":"Traditional Chinese Medicine Huanglian Improves Muscular Endurance in Type 2 Diabetes Patients","authors":"Li Chen, Xi Chen, Runwen Qi, Tao Zhang, Qiang Jiang, Jiaming Ye, Shaohong Zhang, Wen Zhou, Caiying Guo, Jiang Huang, Chao Liu","doi":"10.37290/ctnr2641-452x.21:350-355","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:350-355","url":null,"abstract":"Type 2 diabetes often leads to compromised muscle endurance. Herein, we have explored the effect of Huanglian, a traditional Chinese medicine herb, on muscle endurance in patients with type 2 diabetes. To this end, type 2 diabetes patients aged 18–60 years were recruited and treated with anti-diabetic drugs, or anti-diabetic drugs plus 20 g of Huanglian daily, for one month. All subjects were instructed in muscle endurance assessment guided by the videos from the App in the clinic setting. The baseline and post-intervention muscle endurance values were recorded through the app and compared. The treatment group receiving Huanglian had higher muscle endurance than the control group. Multivariate regression analysis showed that lower limb muscle endurance (OR = 4.282, 95% CI: 1.537–11.928) and upper abdominal muscle endurance (OR = 4.632, 95% CI: 1.847–11.618) were correlated with Huanglian treatment. In conclusion, the level of muscle endurance of the lower limbs and upper abdominals is positively correlated with Huanglian decoction treatment in diabetic patients. The sensitivity of this video-guided test method is comparable to that of traditional equipment and more conducive to clinical application.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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