EFFECT OF MEROPENEM AND IMICENEM ON MICROBIOCENOSIS AND MORPHOLOGY OF THE SMALL INTESTINE IN RATS

Abstract

Background. Gut microbiota plays an important role in the human body, antimicrobial drugs intake being one of the main factors affecting microbiota composition. Antibiotics suppress normal intestinal microflora allowing for the growth and development of pathogenic flora. Objective. To study the effect of meropenem and imicenem on the microbiocenosis and morphology of the small intestine in rats. Material and methods. In an experiment on rats, we analysed the microbiocenosis of the large intestine after intraperitoneal administration of meropenem, imicinem and 0.9% NaCl, as well as examined samples of the small intestine. Results. In a comparative analysis of the control group with the meropenem and imicinem groups, there has been noted a decrease in the number of anaerobes in the meropenem group (8.6±0.14, p<0.05) as compared with the control group (9.4±0.22, p<0 .05) and the imicinem group (9.4±0.40, p<0.05); the number of bifidobacteria decreased in the meropenem group (8.1±0.16, p<0.05) in contrast to the control group (9.2±0.25, p<0.05) and the imicinem group (9.2±0.41, p<0.05). When compared with meropenem (3.8±0.44, p<0.05), imicinem (4.9±0.20, p<0.05) led to a greater growth of spore-forming anaerobes. In animals of the imicinem group, the histostructure of the jejunal mucosa was similar to the control group, while in the meropenem group, inflammatory changes in the stroma of the villi of the jejunal mucosa were observed. Conclusions. In a comparative analysis of carbapenem activity, it has been determined that these antibiotics both have a significant effect on the microbiocenosis of the large intestine and affect the mucous wall of the small intestine. These should be taken into account by clinicians in order to improve the effectiveness and safety of antibiotic therapy.