Current research status of ionizing radiation bleeding syndrome

中国辐射卫生 Pub Date : 2021-08-01 DOI:10.13491/J.ISSN.1004-714X.2021.04.026

Wang Xinmiao, W. Junping, Ran Xinze

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Abstract

Bleeding caused by ionizing radiation involves many factors, the mechanism is complicated and the management is difficult. Bleeding is recognized as one of the main causes of death after ionizing radiation. In this paper, we summarize the pathophysiological mechanisms of ionizing radiation bleeding syndrome (IRBS) from the aspects of platelet abnormality, coagulation disorder and vascular damage. Besides, we expound the clinical characteristics of IRBS in terms of the degree, time and site of the bleeding. Combined with experimental results, we put forward ideas and possible approaches for the treatment of IRBS, and the key factor is to promote the recovery of megakaryocytes and rapid platelet production after radiation exposure. 摘要：电离辐射引起的出血, 涉及原因多, 机制较复杂, 救治困难; 出血更是电离辐射后患者死亡的主要原因之一。本文从血小板异常、凝血障碍、血管受损等方面, 综述了电离辐射出血综合征的病理生理机制;从出血程度、出血时间、出血部位等方面, 阐述了电离辐射出血综合征的临床特点;结合实验研宄结果, 提出了治疗电离辐射出血综合征的思路与可能途径, 关键因素是尽快促进巨核细胞的恢复和快速产生血小板。

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电离辐射出血综合征的研究现状

Bleeding caused by ionizing radiation involves many factors, the mechanism is replicated and the management is complex Bleeding is recognized as one of the main causes of death after ionizing radiation In this paper, we summarize the pathophysiological mechanisms of ionizing radiation blending syndrome (IRBS) from the aspects of plateau abnormality, coaggulation disorder and volatile image Besides, we explore the clinical characteristics of IRBS in terms of the degree, time, and site of the blending Combined with experimental results, we put forward ideas and possible approaches for the treatment of IRBS, and the key factor is to promote the recovery of megakaryocytes and rapid platelet production after radiation exposure Abstract: Bleeding caused by ionizing radiation involves multiple causes, complex mechanisms, and difficult treatment; Bleeding is one of the main causes of death in patients after ionizing radiation. This article reviews the pathophysiological mechanisms of ionizing radiation bleeding syndrome from the perspectives of platelet abnormalities, coagulation disorders, and vascular damage; The clinical characteristics of ionizing radiation bleeding syndrome were elaborated from the aspects of bleeding degree, bleeding time, and bleeding site; Based on the results of experimental research, ideas and possible pathways for the treatment of ionizing radiation bleeding syndrome have been proposed. The key factors are to promote the recovery of megakaryocytes and the rapid production of platelets as soon as possible.

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来源期刊

中国辐射卫生

CiteScore

0.80

自引率

0.00%

发文量

7142

期刊介绍： Chinese Journal of Radiological Health is one of the Source Journals for Chinese Scientific and Technical Papers and Citations and belongs to the series published by Chinese Preventive Medicine Association (CPMA). It is a national academic journal supervised by National Health Commission of the People’s Republic of China and co-sponsored by Institute of Radiation Medicine, Shandong Academy of Medical Sciences and CPMA, and is a professional academic journal publishing research findings and management experience in the field of radiological health, issued to the public in China and abroad. Under the guidance of the Communist Party of China and the national press and publication policies, the Journal actively publicizes the guidelines and policies of the Party and the state on health work, promotes the implementation of relevant laws, regulations and standards, and timely reports new achievements, new information, new methods and new products in the specialty, with the aim of organizing and promoting the academic communication of radiological health in China and improving the academic level of the specialty, and for the purpose of protecting the health of radiation workers and the public while promoting the extensive use of radioisotopes and radiation devices in the national economy. The main columns include Original Articles, Expert Comments, Experience Exchange, Standards and Guidelines, and Review Articles.