{"title":"Comprehensive Insight into Synthetic Strategies of Enigmol and Its Analogs as Therapeutic Agents","authors":"Parleen Kaur, Vasundhara Singh","doi":"10.2174/1570193x19666220820115630","DOIUrl":null,"url":null,"abstract":"\n\n1-Deoxysphingolipids are a class of sphingolipids which lacks the primary hydroxyl group\n(C1-OH). Hence, it does not get converted/degraded to complex corresponding products like sphingosine-1-phosphate (SIP), a pro-mitotic. Enigmol, an orally bioavailable 1-deoxyphingolipid has shown\npotential against various different types of cancer cells along with impressive cytotoxic/antiproliferative properties. Due to its unique structural properties, Enigmol and its analogs have\nattracted considerable attention from synthetic organic chemists. This review provides an overview of\nall the synthetic approaches being followed for the synthesis of Enigmol and its structural analogs.\n","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini-reviews in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/1570193x19666220820115630","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
1-Deoxysphingolipids are a class of sphingolipids which lacks the primary hydroxyl group
(C1-OH). Hence, it does not get converted/degraded to complex corresponding products like sphingosine-1-phosphate (SIP), a pro-mitotic. Enigmol, an orally bioavailable 1-deoxyphingolipid has shown
potential against various different types of cancer cells along with impressive cytotoxic/antiproliferative properties. Due to its unique structural properties, Enigmol and its analogs have
attracted considerable attention from synthetic organic chemists. This review provides an overview of
all the synthetic approaches being followed for the synthesis of Enigmol and its structural analogs.
期刊介绍：
Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges.
The journal encourages submission of reviews on emerging fields of organic chemistry including:
Bioorganic Chemistry
Carbohydrate Chemistry
Chemical Biology
Chemical Process Research
Computational Organic Chemistry
Development of Synthetic Methodologies
Functional Organic Materials
Heterocyclic Chemistry
Macromolecular Chemistry
Natural Products Isolation And Synthesis
New Synthetic Methodology
Organic Reactions
Organocatalysis
Organometallic Chemistry
Theoretical Organic Chemistry
Polymer Chemistry
Stereochemistry
Structural Investigations
Supramolecular Chemistry
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