Genetic Engineering to Induce Fetal-Like Hematopoietic Stem Cells

Bariş Ulum, S. Muljo
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Abstract

Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is an archetype of cellular therapy. However, to date BMT still suffers from several complications. Recent technological advances have encouraged us to think about an alternative to traditional BMT. Specifically, we propose in utero HSCT (IUHSCT). For this purpose, we suggest that induced fetal-like hematopoietic stem cells (ifHSCs) might be suitable for IUHSCT, and should be seriously evaluated.
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基因工程诱导胎儿样造血干细胞
骨髓移植(BMT)或造血干细胞移植(HSCT)是细胞治疗的一种原型。然而,迄今为止,BMT仍然存在一些并发症。最近的技术进步鼓励我们考虑传统BMT的替代方案。具体来说,我们提出子宫内HSCT (IUHSCT)。为此,我们建议诱导胎儿样造血干细胞(ifhsc)可能适合IUHSCT,并应认真评估。
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