Protective effect of Luteolin on atopic dermatitis murine model via IgE mediated immune response

IF 0.9 4区 生物学 Q4 PLANT SCIENCES Israel Journal of Plant Sciences Pub Date : 2021-03-18 DOI:10.1163/22238980-BJA10029
Jian Wang, Gang Li, Haixiu Zhang, Ying Xie
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引用次数: 1

Abstract

Atopic dermatitis (AD) is a serious inflammatory condition associated with severe itching and persistent eczematous lesion. Therefore, the present study was intended to scrutinize the beneficial effect of Luteolin (LT) on the atopic dermatitis murine model. The effect of LT was investigated on the various parameters, such as oxidative stress and inflammation after induction of AD. The serum level of IgE, and cells of the WBC family (neutrophils, basophils, eosinophils, monocytes, lymphocytes, and total WBC) and histopathological analysis of skin tissue were also examined to confirm the effect of LT. Results of the study suggested that LT significantly inhibited the elevated IgE level together with improvement in injured skin tissue architecture. It also reduces oxidative stress (MDA, SOD, and GSH) and inflammation (IL-1β, IL-6, TNF-α, IFN-γ, IL-4, and IL-17A) as evidenced by ELISA analysis. The level of examined WBC family cells was found reduced significantly as compared to the AD model group. In western blot analysis, LT showed significant down-regulation of NF-ĸB and TLR-4. Collectively, our results suggest that LT can effectively reverse the effect of atopic dermatitis via improving immunological response.
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木犀草素通过IgE介导的免疫应答对小鼠特应性皮炎模型的保护作用
特应性皮炎(AD)是一种严重的炎症性疾病,伴有严重瘙痒和持续性湿疹样病变。因此,本研究旨在观察木犀草素(LT)对特应性皮炎小鼠模型的有益作用。研究了LT对各种参数的影响,如AD诱导后的氧化应激和炎症。还检查了血清IgE水平和WBC家族细胞(中性粒细胞、嗜碱性粒细胞、酸性粒细胞、单核细胞、淋巴细胞和总WBC)以及皮肤组织的组织病理学分析,以证实LT的影响。研究结果表明,LT显著抑制了IgE水平的升高,并改善了损伤的皮肤组织结构。ELISA分析表明,它还可以降低氧化应激(MDA、SOD和GSH)和炎症(IL-1β、IL-6、TNF-α、IFN-γ、IL-4和IL-17A)。发现与AD模型组相比,所检查的WBC家族细胞的水平显著降低。在蛋白质印迹分析中,LT显示NF-ĸB和TLR-4的显著下调。总之,我们的研究结果表明,LT可以通过改善免疫反应有效逆转特应性皮炎的影响。
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来源期刊
Israel Journal of Plant Sciences
Israel Journal of Plant Sciences 生物-植物科学
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: The Israel Journal of Plant Sciences is an international journal of extensive scope that publishes special issues dealing with all aspects of plant sciences, including but not limited to: physiology, cell biology, development, botany, genetic
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