{"title":"Research progress on function of regulatory T cell in myeloproliferative neoplasms","authors":"Yunguang Hong, R. Wen, Zhigang Yang","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.03.008","DOIUrl":null,"url":null,"abstract":"Myeloproliferative neoplasms (MPN) are a group of abnormal clonal diseases of hematopoietic stem cell, which characterized by sustained clonal proliferation of relatively mature differentiated one or more myeloid cells. MPN mainly include chronic myeloid leukemia (CML) and Ph-/MPN. In recent years, studies have reported that abnormal number and function of regulatory T cell (Treg) play an important role in the occurrence and development of MPN. Therefore, this article reviews recent research advances in the biological characteristics of Treg, relationship between number of Treg in CML patients and CML clinical phase, Sokal score, efficacy and transcription level of BCR-ABL fusion gene, as well as the role of Treg in the pathogenesis and progression of Ph- MPN. Key words: T-lymphocytes; T-lymphocytes, regulatory; Myeloproliferative disorders; Leukemia, myelogenous, chronic, BCR-ABL positive; Treatment outcome; Neoplasm staging","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"223-228"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.03.008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Myeloproliferative neoplasms (MPN) are a group of abnormal clonal diseases of hematopoietic stem cell, which characterized by sustained clonal proliferation of relatively mature differentiated one or more myeloid cells. MPN mainly include chronic myeloid leukemia (CML) and Ph-/MPN. In recent years, studies have reported that abnormal number and function of regulatory T cell (Treg) play an important role in the occurrence and development of MPN. Therefore, this article reviews recent research advances in the biological characteristics of Treg, relationship between number of Treg in CML patients and CML clinical phase, Sokal score, efficacy and transcription level of BCR-ABL fusion gene, as well as the role of Treg in the pathogenesis and progression of Ph- MPN. Key words: T-lymphocytes; T-lymphocytes, regulatory; Myeloproliferative disorders; Leukemia, myelogenous, chronic, BCR-ABL positive; Treatment outcome; Neoplasm staging
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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