Mechanistic Model of Radiation-Induced Bystander Effects to Cells using Structured Population Approach

IF 0.3 Q4 MATHEMATICS Matematika Pub Date : 2018-12-31 DOI:10.11113/MATEMATIKA.V34.N3.1147
Fuaada Mohd Siam, M. Nasir
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引用次数: 0

Abstract

In irradiation process, instead of traverse on the targeted cells, there is side effect happens to non-targeted cells. The targeted cells that had been irradiated with ionizing radiation emits damaging signal molecules to the surrounding and then, damage the bystander cells. The type of damage considered in this work is the number of double-strand breaks (DSBs) of deoxyribonucleic acid (DNA) in cell’s nucleus. By using mathematical approach, a mechanistic model that can describe this phenomenon is developed based on a structured population approach. Then, the accuracy of the model is validated by its ability to match the experimental data. The Particle Swarm (PS) optimization is employed for the data fitting procedure. PS optimization searches the parameter value that minimize the errors between the model simulation data and experimental data. It is obtained that the mathematical modelling proposed in this paper is strongly in line with the experimental data.
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用结构群体方法建立辐射诱导细胞旁观者效应的机制模型
在照射过程中,非靶向细胞会产生副作用,而不是穿过靶向细胞。受到电离辐射照射的靶细胞会向周围发出破坏性的信号分子,然后破坏旁观者的细胞。这项工作中考虑的损伤类型是细胞核中脱氧核糖核酸(DNA)的双链断裂次数。通过使用数学方法,在结构化总体方法的基础上开发了一个可以描述这种现象的机制模型。然后,通过模型与实验数据的匹配能力验证了模型的准确性。数据拟合过程采用粒子群算法。PS优化搜索使模型模拟数据和实验数据之间的误差最小化的参数值。结果表明,本文提出的数学模型与实验数据非常吻合。
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来源期刊
Matematika
Matematika MATHEMATICS-
自引率
25.00%
发文量
0
审稿时长
24 weeks
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