{"title":"Research progress in pathogenesis, diagnosis and treatment of anthracyclines related cardiotoxicity","authors":"Yu Tian","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.04.012","DOIUrl":null,"url":null,"abstract":"Anthracyclines (ANT) are cytotoxic drugs that are highly effective against a variety of malignancies and are widely used in the treatment of childhood malignancies.But the dose-cumulative cardiotoxicity associated with anthracyclines can affect the quality of life in children, and even cause heart failure. In recent years, with the recognition of the cardiotoxicity of ANT, cardiac monitoring has become necessary to patients treated with ANT and to take early interventions to prevent or treat heart failure.This article reviews the recent advances in the pathogenesis, diagnosis and treatment of ANT related cardiotoxicity. \n \n \nKey words: \nAnthracyclines; Drug toxicity; Cardiotoxins; Heart failure; Dexrazoxane","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"351-357"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.04.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Anthracyclines (ANT) are cytotoxic drugs that are highly effective against a variety of malignancies and are widely used in the treatment of childhood malignancies.But the dose-cumulative cardiotoxicity associated with anthracyclines can affect the quality of life in children, and even cause heart failure. In recent years, with the recognition of the cardiotoxicity of ANT, cardiac monitoring has become necessary to patients treated with ANT and to take early interventions to prevent or treat heart failure.This article reviews the recent advances in the pathogenesis, diagnosis and treatment of ANT related cardiotoxicity.
Key words:
Anthracyclines; Drug toxicity; Cardiotoxins; Heart failure; Dexrazoxane
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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