Polyethylene Glycol as New Permeation Enhancer in Thermosensitive Mucoadhesive Hydrogels Containing Hydrophobic Compound for Vaginal Delivery: An Ex Vivo Proof of Concept Study
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引用次数: 1
Abstract
As an excellent alternative, the vaginal route has been widely investigated to deliver different types of drugs. However, the delivery of hydrophobic drugs via conventional preparation is challenging. Here, for the first time, we investigated using PEG as a permeation enhancer in thermosensitive mucoadhesive hydrogels containing Nile red as a model of the hydrophobic compound. Pluronic® F127 (P127) and Pluronic® F68 (P68) were used as thermosensitive agents, and HPMC was used as mucoadhesive agents. The results showed that the concentration of PEG did not change the gelation temperature, mucoadhesive properties, pH, recovery, and rheological behavior of hydrogels. Finally, using PEG could improve the ex vivo permeation and retention profiles of Nile red up to 20-folds and 15-folds, respectively. Following the promising results of this proof of concept study, the application of PEG in improving the vaginal delivery of therapeutic agents should be carried out.
期刊介绍：
Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.
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