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Editorial. Thirteen Years of Free Publication: From the Optimistic Horizons to Failure and Discreditation 社论。自由出版十三年:从乐观的视野到失败和名誉扫地
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2023-04-23 DOI: 10.33263/briac141.001
We would like to express our gratitude to all Authors, Reviewers, and Editorial BoardMembers that support this project unconditionally. We are also grateful to all scientistsinvolved in this project since 2011 or who joined during the years. Volume 13, for the year2023, was completed on April 11, 2023. It was composed of 600 papers, published free ofcharge. Now, it starts Volume 14, for 2024, with ~8 months in advance. It seems that our dedication and passion for science were flagged as “unrelated” by “a new, internally developed AI tool to help us identify outlier characteristics that indicate that ajournal may no longer meet our quality criteria”1. In the following, from the optimistic horizons to failure and discreditation.
我们要对所有无条件支持这个项目的作者、审稿人和编辑委员会成员表示感谢。我们也感谢自2011年以来参与该项目或在此期间加入的所有科学家。2023年的第13卷于2023年4月11日完成。它由600篇论文组成,免费出版。现在,它开始了第14卷,2024年,提前约8个月。我们对科学的奉献和热情似乎被“一种新的、内部开发的人工智能工具”标记为“无关”,以帮助我们识别表明期刊可能不再符合我们质量标准的异常特征”1。接下来,从乐观的视野到失败和失信。
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引用次数: 0
Antibacterial Properties of Graphene and its Reinforcement Effect on Compressive Properties of PMMA 石墨烯的抗菌性能及其对PMMA压缩性能的增强作用
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.393
Graphene and its derivatives have received significant attention due to their outstanding properties. This study aims to evaluate the antibacterial properties of graphene and its reinforcement effect on the mechanical properties of polymethyl methacrylate (PMMA) for potential bone substitution. The morphology of graphene was initially observed via a field emission scanning electron microscope (FESEM). Five concentrations of graphene (1, 0.5, 0.25, 0.125, and 0.0625 mg/mL) were then prepared, and its antibacterial properties were assessed against Staphylococcus aureus. Two concentrations that exhibited the highest antibacterial properties were selected and incorporated with PMMA. Graphene exhibited superior antibacterial properties at 0.5 and 1.0 mg/mL concentrations. The 0.5 mg/mL graphene-reinforced PMMA presented an increment of compressive strength by up to 48% and a compressive modulus of 72% compared to unfilled PMMA. In conclusion, the PMMA composite with improved biological and mechanical performance could be potentially used as a bone substitution.
石墨烯及其衍生物因其优异的性能而备受关注。本研究旨在评估石墨烯的抗菌性能及其对聚甲基丙烯酸甲酯(PMMA)潜在骨替代物力学性能的增强作用。石墨烯的形态最初是通过场发射扫描电子显微镜(FESEM)观察到的。然后制备五种浓度的石墨烯(1、0.5、0.25、0.125和0.0625mg/mL),并评估其对金黄色葡萄球菌的抗菌性能。选择表现出最高抗菌性能的两种浓度,并将其与PMMA结合。石墨烯在0.5和1.0mg/mL浓度下表现出优异的抗菌性能。与未填充的PMMA相比,0.5mg/mL石墨烯增强的PMMA表现出高达48%的压缩强度增量和72%的压缩模量。总之,具有改进的生物和机械性能的PMMA复合材料有可能用作骨替代物。
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引用次数: 1
The Theoretical Description for Amavadin-Ion Electrochemical Determination in Amanita muscaria Mushroom Pulp and Extract by Galvanostatic Conducting Polymer Doping 恒电流导电聚合物掺杂法电化学测定鹅膏菌浆及提取物中阿玛丁的理论描述
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.400
The theoretical description for amavadin-ion electrochemical determination in mushroom pulp has been given for the first time. The correspondent mathematical model has been developed and analyzed by linear stability theory and bifurcation analysis, providing the theoretical investigation of the electrochemical behavior of the electroanalytical system. It has been shown that the system behavior in galvanostatic mode is more dynamic than in potentiostatic mode, which is reflected in the enhancement of the probability of the electrochemical oscillations due to the intense influence of chemical and electrochemical stages on both DEL and surface charge. Nevertheless, the system is efficient for electroanalysis or conducting polymer modification for electroanalytical purposes.
首次对蘑菇果肉中阿玛瓦丁离子的电化学测定方法进行了理论描述。建立了相应的数学模型,并运用线性稳定性理论和分岔分析方法对其进行了分析,为电分析体系的电化学行为提供了理论依据。研究表明,恒流模式下的系统行为比恒电位模式下更动态,这反映在化学和电化学阶段对DEL和表面电荷的强烈影响使电化学振荡的概率增强。然而,该系统对于电分析或为电分析目的进行聚合物改性是有效的。
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引用次数: 0
Using Bio-Realistic Gaussian-Shaped Population and Dopamine-Modulated STDP for Training a Self-Balancing System 利用生物真实高斯型种群和多巴胺调制STDP训练自平衡系统
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.398
Human body balance is a gradual formation through repetition of actions, trial and error, and improving the mechanism of muscular-skeletal architecture for adapting to the demands of the environment. In the learning process, sensory receptors continuously send signals to the brain, then the brain to muscles and make a new signals pathway. Each time the body performs an action, millions of new synaptic connections are formed, and repetitive actions strengthen connections. So, a balanced body reuses the learned mechanism without performing any complex calculations. In contrast, the balance problem of a self-balancing robot has been solved by many different control algorithms. In this work, we propose a novel way to balance a two-wheeled self-balancing robot using bio-realistic Spiking Neural Networks (SNNs) to learn self-balancing, which is closely related to the way babies learn. To accomplish this, the gaussian shaped sensory neuronal population is connected with motor neurons through Spike-Timing-Dependent Plasticity (STDP) based synapses, further controlled with dopamine neurons. The key aspects of this approach are its bio-realistic nature and zero dependencies on data for adopting a new behavior compared to Deep Reinforcement Learning. Furthermore, this biologically-inspired mechanism can be used to improve the methodology for programming the robots to mimic Biological Intelligence.
人体平衡是通过反复的动作、试错、完善肌肉骨骼结构适应环境要求的机制而逐渐形成的。在学习过程中,感觉受体不断向大脑发送信号,再由大脑向肌肉发出新的信号通路。每当身体执行一个动作时,就会形成数百万个新的突触连接,而重复的动作会加强这些连接。因此,平衡体无需执行任何复杂的计算即可重用学习的机制。相比之下,自平衡机器人的平衡问题已经被许多不同的控制算法所解决。在这项工作中,我们提出了一种新的方法来平衡两轮自平衡机器人,利用生物逼真的峰值神经网络(SNNs)来学习自平衡,这与婴儿的学习方式密切相关。为了实现这一目标,高斯形感觉神经元群通过基于spike - time - dependent Plasticity (STDP)的突触与运动神经元连接,进一步由多巴胺神经元控制。与深度强化学习相比,这种方法的关键方面是其生物现实性和采用新行为对数据的零依赖。此外,这种受生物学启发的机制可用于改进机器人模拟生物智能的编程方法。
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引用次数: 0
Microstructure and Elastic Properties of Hydroxyapatite/Alumina Nanocomposites Prepared by Mechanical Alloying Technique for Biomedical Applications 机械合金化技术制备羟基磷灰石/氧化铝纳米复合材料的微观结构和弹性性能
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.395
Although hydroxyapatite (HA) has exceptional biological qualities that inspire researchers to employ it as an appealing biomaterial for various purposes, its usage in hard tissue replacement applications is severely restricted because of its fragility. In order to create nanocomposites with the necessary mechanical properties for biomedical applications, HA was produced, and various amounts of alumina (Al2O3) were added to it. Additionally, the phase composition of the powdered nanocomposites was examined using the X-ray diffraction (XRD) technique. Crystal sizes, lattice strain, and dislocation density were all estimated as well. In order to measure the produced nanocomposite powders’ physical and elastic characteristics using the Archimedes method and ultrasonic non-destructive technique, they were then pressed and sintered at 1000 °C. The resulting information made it clear that further increases in the weight percentages of Al2O3 resulted in a 10.25, 25.64, and 33.33% reduction in crystal size. As a result of adding more Al2O3-up to 20 weight, percent-the results also showed that this properties-microhardness, compressive strength, Young’s modulus, elastic modulus, bulk modulus, shear modulus, and Poisson’s ratio-were improved by 109, 36.29, 95.5, 100.59, 104.97, 92.84 and 9.5%, respectively. Unfortunately, it increased its porosity by considerable amounts. It might be argued that the generated nanocomposites are favorable for biomedical applications.
尽管羟基磷灰石(HA)具有非凡的生物学特性,激发了研究人员将其作为一种有吸引力的生物材料用于各种用途,但由于其脆性,其在硬组织替代应用中的应用受到严重限制。为了制备具有生物医学应用所需机械性能的纳米复合材料,制备了HA,并在其中添加了不同量的氧化铝(Al2O3)。此外,使用X射线衍射(XRD)技术检测了粉末状纳米复合材料的相组成。晶体尺寸、晶格应变和位错密度也都得到了估计。为了使用阿基米德法和超声波无损检测技术测量所制备的纳米复合粉末的物理和弹性特性,然后在1000°C下对其进行压制和烧结。所得信息清楚地表明,Al2O3重量百分比的进一步增加导致晶体尺寸减小10.25%、25.64和33.33%。结果还表明,添加更多的Al2O3至20重量%时,该性能的显微硬度、抗压强度、杨氏模量、弹性模量、体积模量、剪切模量和泊松比分别提高了109、36.29、95.5、100.59、104.97、92.84和9.5%。不幸的是,它增加了大量的孔隙率。可以说,所产生的纳米复合材料有利于生物医学应用。
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引用次数: 3
Double Diffusion, Chemical Reaction, and Heat Source Effects on Magnetohydrodynamic Flow of Copper and Silver Water-based Nanofluids over a Moving Vertical Porous Plate 双扩散、化学反应和热源对铜和银水基纳米流体在移动的垂直多孔板上磁流体动力学流动的影响
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.394
In this manuscript, the impact of Soret and Dufour numbers on magnetohydrodynamic (MHD) flow for Silver (Ag) and Copper (Cu) water-based nanofluids past a moving plate over a porous medium are investigated numerically. The influences of heat sources and chemical reactions are also considered, as their applications are prevalent in several industries. The flow's constituents' governing equations are coupled with Partial differential equations (PDEs) that are converted into a dimensionless form using appropriate flow parameters. Subsequently, the finite-difference technique is used to resolve the resulting equations. The varied effects of flow parameters on the momentum, temperature, and concentration boundary layers are investigated using various graphs. The results presented in terms of non-dimensional parameters like shear stress factor, Sherwood number, and Nusselt number of fluids are tabulated for the nanofluids Ag-water and Cu-water. It is found that the augmented values of Dufour and Soret numbers enhance the fluid velocity. However, the species concentration decreases in the existence of Dufour and chemical reaction effects.
在本文中,数值研究了Soret和Dufour数对银(Ag)和铜(Cu)水基纳米流体通过多孔介质上移动板的磁流体动力学(MHD)流动的影响。热源和化学反应的影响也被考虑在内,因为它们的应用在几个行业中很普遍。流量成分的控制方程与偏微分方程(PDE)相耦合,偏微分方程使用适当的流量参数转换为无量纲形式。随后,使用有限差分技术来求解所得到的方程。使用各种图表研究了流动参数对动量、温度和浓度边界层的不同影响。表中列出了纳米流体Ag水和Cu水的无量纲参数,如剪切应力因子、流体的Sherwood数和Nusselt数。研究发现,Dufour数和Soret数的增广值提高了流体的速度。然而,物种浓度的降低是由于Dufour的存在和化学反应的影响。
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引用次数: 0
Poly(9-Vinylcarbazole)/Graphene Nanoheterostructure Interfaces: Ab Initio Dynamics Studies for Photovoltaic and Optoelectronic Applications 聚(9-乙烯基咔唑)/石墨烯纳米异质结构界面:光伏光电应用从头算动力学研究
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.399
Polymer photovoltaics have great technological potential as an alternative source of electrical energy. The demand for inexpensive, renewable energy sources drives new approaches to produce low-cost polymer solar cells. In the last decade, the development of these solar cells has progressed rapidly. One of the limiting parameters of these polymer photovoltaics is the mismatch between their absorption spectrum and the terrestrial solar spectrum. Using low-band-gap polymers is a viable method to expand the absorption spectrum of solar cells and increase their efficiency. We report first-principles calculations on the binding of Poly(9-vinylcarbazole), PVK, to graphene. Considering the different relative orientations of the subsystems, our calculations predict reasonable binding energies, demonstrating interactions between the polymer and graphene. The band gap value we have calculated in this work is low enough to make the nanoheterostructure exceedingly promising for photovoltaic applications.
聚合物光伏作为一种替代能源具有巨大的技术潜力。对廉价可再生能源的需求推动了生产低成本聚合物太阳能电池的新方法。在过去的十年里,这些太阳能电池的开发进展迅速。这些聚合物光伏的限制参数之一是其吸收光谱与地面太阳光谱之间的不匹配。使用低带隙聚合物是扩大太阳能电池吸收光谱并提高其效率的可行方法。我们报道了聚(9-乙烯基咔唑)PVK与石墨烯结合的第一性原理计算。考虑到子系统的不同相对取向,我们的计算预测了合理的结合能,证明了聚合物和石墨烯之间的相互作用。我们在这项工作中计算的带隙值足够低,使纳米异质结构在光伏应用中非常有前景。
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引用次数: 0
Investigation on Controlling Therapy of Bone Skeletal and Marrow Cancer: A Biophysical Chemistry and Molecular Dynamic Study of Bisphosphonates Interaction with Bone Structures 骨骼肌和骨髓癌的控制治疗研究:双磷酸盐与骨结构相互作用的生物物理化学和分子动力学研究
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.396
For more than four decades, the bisphosphonates family has been applied for osteoporosis and skeletal metastasis therapy. These drugs decrease the viability of cancer cells that are guided through the HER group of receptor tyrosine kinases. We discussed that bisphosphonates straightly bind to and inhibit HER kinases. In this study for docking a nitrogen-containing bisphosphonate with human FPPS and a few other targets, the iGEMDOCK docking software has been used. Nitrogen-containing bisphosphonates (NBPs) are mostly applied for bone treatment and also for the loss of skeletal disorders. The adsorption, retention, diffusion, and release of (NBPs) in bone are controlled by their affinities to such mineral compounds. Bisphosphonates have a high affinity for Ca2+ and therefore attack bone minerals, where they are internalized by bone-resorbing osteoclasts and inhibit osteoclast function. Nitrogen-containing bisphosphonates (NBPs), including Alendronate, Zolendronate, Risedronic, Ibandronate, and Pamidronate, are functionalized as effective inhibitors of bone resorption diseases. It targets FPPS (osteoclast farnesyl pyrophosphate synthase) to inhibit protein prenylation. Generally, the strong interaction sequence is as follows Alendronate > Risedronic > Pamidronate > Zolendronate > Ibandronate, and this was because of strong electrostatic interactions between amine groups and phosphate ions.
四十多年来,双膦酸盐家族已被应用于骨质疏松症和骨骼转移治疗。这些药物降低了通过HER受体酪氨酸激酶组引导的癌细胞的生存能力。我们讨论了双膦酸盐直接结合并抑制HER激酶。本研究采用iGEMDOCK对接软件实现含氮双膦酸盐与人FPPS及其他靶点的对接。含氮双膦酸盐(NBPs)主要用于骨治疗和骨骼疾病的丧失。NBPs在骨中的吸附、保留、扩散和释放受其对此类矿物化合物的亲和力控制。双磷酸盐对Ca2+有很高的亲和力,因此攻击骨矿物质,在那里它们被骨吸收破骨细胞内化并抑制破骨细胞的功能。含氮双膦酸盐(NBPs),包括阿仑膦酸盐、唑仑膦酸盐、利塞膦酸盐、伊班膦酸盐和帕米膦酸盐,被功能化为骨吸收疾病的有效抑制剂。它以FPPS(破骨细胞法尼基焦磷酸盐合成酶)为靶点,抑制蛋白质烯酰化。一般来说,强相互作用的顺序为:阿仑膦酸盐>利塞膦酸盐>帕米膦酸盐> Zolendronate >伊班膦酸盐,这是由于胺基与磷酸盐离子之间的强静电相互作用。
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引用次数: 0
Comparative Review of Different Adsorption Techniques Used in Heavy Metals Removal in Water 不同吸附技术去除水中重金属的比较研究
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-11-01 DOI: 10.33263/briac134.397
The rising shortage of water resources and the need to provide water in many regions like Morocco around the world has been crucial and will become increasingly alarming in the future. Water bodies can be practically polluted or impaired by industrial, agricultural, and anthropogenic waste. Heavy metals are widely known environmental contaminants due to their toxicity, prevalence, and bioaccumulation. They build up in the environment, disrupting the food chains as chronic pollutants. In organisms, including humans, the deposition of possibly hazardous heavy metals poses a significant threat to health. This review paper highlights the present research on heavy metal removal, focusing on adsorbents and techniques accessible and feasible, such as adsorptive separation by substances, including a metal oxide, graphene, zeolite, and carbon-based composites. These techniques received a lot of acknowledgment due to their significant active surface area, high proportion of functional groups, increased chemical and thermal stability, and impressive adsorption efficiency and efficacy. The economic aspects and feasibility of adsorbents have also been presented.
水资源日益短缺,世界各地像摩洛哥这样的许多地区都需要供水,这一点至关重要,而且在未来将变得越来越令人担忧。水体实际上可能受到工业、农业和人为废物的污染或损害。重金属因其毒性、普遍性和生物累积性而成为众所周知的环境污染物。它们在环境中积累,作为慢性污染物扰乱食物链。在包括人类在内的生物体中,可能有害的重金属的沉积对健康构成重大威胁。这篇综述文章重点介绍了目前对重金属去除的研究,重点介绍了可获得和可行的吸附剂和技术,如通过金属氧化物、石墨烯、沸石和碳基复合材料等物质进行吸附分离。这些技术因其显著的活性表面积、高比例的官能团、增加的化学和热稳定性以及令人印象深刻的吸附效率和功效而受到广泛认可。还介绍了吸附剂的经济性和可行性。
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引用次数: 12
FEA Analysis of TI-6AL-4V and 30% Collagen Reinforced PMC Used as Biomaterials for Ankle Implants 钛-6AL-4V和30%胶原蛋白增强PMC用作踝关节植入物生物材料的有限元分析
Q3 Biochemistry, Genetics and Molecular Biology Pub Date : 2022-10-31 DOI: 10.33263/briac134.378
This paper deals with the feasibility study of using existing biomaterials like titanium alloy and the collagen-reinforced polymer matrix composite for ankle implant application through FEA analysis. The ankle joint is the important joint in the human body that experience maximum compressive stresses and undergoes maximum deformation. It must evaluate properties like stress concentration, deformation zone, and material behavior. The analysis was carried out in ANSYS Workbench with different loading conditions, for instance, normal walking and sprinting. The analysis showed that both the Ti-6Al-4V and the 30% collagen-reinforced PMC exhibited minimum stresses, but since the density of Ti-6Al-4V is more than 30% collagen-reinforced PMC. Even though the stress developed in Ti-6Al-4V is within the yield stress, the density is still not close enough to the density of bone. Collagen-reinforced PMC with a 30% density close to the bone is recommended as an implant material for better life and performance.
本文通过有限元分析,探讨了钛合金、胶原增强聚合物基复合材料等现有生物材料用于踝关节植入的可行性。踝关节是人体承受最大压应力和承受最大变形的重要关节。它必须评估诸如应力集中、变形区和材料行为等特性。在ANSYS Workbench中进行了正常行走和冲刺等不同加载条件下的分析。分析表明,Ti-6Al-4V和30%胶原增强PMC均表现出最小的应力,但由于Ti-6Al-4V的密度大于30%胶原增强PMC。尽管在Ti-6Al-4V中产生的应力在屈服应力范围内,但密度仍然不够接近骨的密度。胶原蛋白增强的PMC密度接近骨骼30%,推荐作为种植材料,以获得更好的使用寿命和性能。
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引用次数: 0
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Biointerface Research in Applied Chemistry
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