{"title":"The Effect of Gum Arabic on Cholesterol Synthesis and Serum Lipids in Atherogenic Rats","authors":"Abuelgassim Omer Abuelgassim, Abeer Al-Otaibi, Seema Zargar","doi":"10.37290/ctnr2641-452x.21:163-168","DOIUrl":null,"url":null,"abstract":"In the current study, we have evaluated the effect of gum Arabic on cholesterol homeostasis in atherogenic rats. To this end, adult male Wistar rats were treated orally with increasing concentrations of gum Arabic for 6 consecutive weeks, and serum concentrations of markers of cholesterol homeostasis (total cholesterol, low-density lipoprotein, and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity) were evaluated. Treatment of atherogenic rats with gum Arabic improved serum levels of markers of cholesterol homeostasis. Also, gum Arabic did not reveal any harmful effect on the liver tissue of normal control rats, whereas the liver tissue of atherogenic-treated rats showed improvements in healing, inflammation, and necrosis. In conclusion, gum Arabic may serve to improve cholesterol homeostasis in patients with hypercholesterolemia.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Topics in Nutraceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.37290/ctnr2641-452x.21:163-168","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
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Abstract
In the current study, we have evaluated the effect of gum Arabic on cholesterol homeostasis in atherogenic rats. To this end, adult male Wistar rats were treated orally with increasing concentrations of gum Arabic for 6 consecutive weeks, and serum concentrations of markers of cholesterol homeostasis (total cholesterol, low-density lipoprotein, and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity) were evaluated. Treatment of atherogenic rats with gum Arabic improved serum levels of markers of cholesterol homeostasis. Also, gum Arabic did not reveal any harmful effect on the liver tissue of normal control rats, whereas the liver tissue of atherogenic-treated rats showed improvements in healing, inflammation, and necrosis. In conclusion, gum Arabic may serve to improve cholesterol homeostasis in patients with hypercholesterolemia.
期刊介绍：
Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products.
To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine.
The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.
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