Effects of B2O3 (boron trioxide) on colon cancer cells: our first-step experience and in vitro results

IF 1.1 4区 生物学 Q3 BIOLOGY Turkish Journal of Biology Pub Date : 2019-06-13 DOI:10.3906/biy-1901-34
Özgür Albuz, D. Dülger, B. Ç. Tunalı, Feray Aydin, S. Yalçın, M. Türk
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引用次数: 7

Abstract

Boron oxide (B2O3) is derived from dehydration of boric acid and is a colorless, semitransparent, crystalline compound that is moderately soluble in water. On the other hand, boron oxide is chemically hygroscopic. This gives the molecule the ability to soak up water and adhere to tissues. Boron oxide can be used locally after tumor debulking in inoperable tumors and especially when the tumor-free margin distance cannot be provided. For all these reasons we aimed to evaluate the in vitro test results of B2O3 in terms of cytotoxicity, genotoxicity, apoptosis, and necrotic effects on L929 fibroblast cells and DLD-1 colorectal adenocarcinoma cells. Our studies demonstrated that boron oxide compounds appear to be highly cytotoxic for both cell lines according to WST cell viability assay (44.22% and 18.36% on DLD-1 and L929, respectively). Although no genotoxic effects were observed, boron oxide compounds showed antiproliferative effects for both cell lines. The prepared boron oxide compounds may hold the potential to be applied locally to the remaining tissue after surgery and further research and evaluation will be needed to determine its effectiveness.
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B2O3(三氧化二硼)对结肠癌细胞的影响:我们的第一步经验和体外结果
氧化硼(B2O3)来源于硼酸的脱水,是一种无色半透明的结晶化合物,适度溶于水。另一方面,氧化硼具有化学吸湿性。这使分子能够吸收水分并粘附在组织上。在无法手术的肿瘤中,氧化硼可以在肿瘤消退后局部使用,尤其是当不能提供肿瘤游离边缘距离时。出于所有这些原因,我们旨在评估B2O3对L929成纤维细胞和DLD-1结直肠癌细胞的细胞毒性、遗传毒性、细胞凋亡和坏死作用的体外测试结果。我们的研究表明,根据WST细胞活力测定,氧化硼化合物似乎对两种细胞系都具有高度的细胞毒性(DLD-1和L929分别为44.22%和18.36%)。尽管没有观察到基因毒性作用,但氧化硼化合物对两种细胞系都显示出抗增殖作用。制备的氧化硼化合物可能具有在手术后局部应用于剩余组织的潜力,需要进一步的研究和评估来确定其有效性。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: The Turkish Journal of Biology is published electronically 6 times a year by the Scientific and Technological Research Council of Turkey (TÜBİTAK) and accepts English-language manuscripts concerning all kinds of biological processes including biochemistry and biosynthesis, physiology and metabolism, molecular genetics, molecular biology, genomics, proteomics, molecular farming, biotechnology/genetic transformation, nanobiotechnology, bioinformatics and systems biology, cell and developmental biology, stem cell biology, and reproductive biology. Contribution is open to researchers of all nationalities.
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