首页 > 最新文献

Turkish Journal of Biology最新文献

英文 中文
TNFR1 signaling is positively regulated by Jak-2 and c-Src via tyrosine phosphorylation TNFR1 信号通过酪氨酸磷酸化受 Jak-2 和 c-Src 的正向调节
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2677
Fatma Zehra HAPİL ZEVKLİLER, Fatma Ece Çopuroğlu, M. G. Ertosun, U. Mert, Derya Özeş, O. N. Özeş
{"title":"TNFR1 signaling is positively regulated by Jak-2 and c-Src via tyrosine phosphorylation","authors":"Fatma Zehra HAPİL ZEVKLİLER, Fatma Ece Çopuroğlu, M. G. Ertosun, U. Mert, Derya Özeş, O. N. Özeş","doi":"10.55730/1300-0152.2677","DOIUrl":"https://doi.org/10.55730/1300-0152.2677","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells 黑色素瘤细胞对 c-Src 抑制剂 Si162 敏感性的预后基因生物标志物
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2678
Seyhan Türk, A. Yilmaz, Ü. Malkan, Gulberk Ucar, Can Türk
{"title":"Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells","authors":"Seyhan Türk, A. Yilmaz, Ü. Malkan, Gulberk Ucar, Can Türk","doi":"10.55730/1300-0152.2678","DOIUrl":"https://doi.org/10.55730/1300-0152.2678","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theranostic potential of a novel aptamer specifically targeting HER2 in breast cancer cells 特异性靶向乳腺癌细胞中 HER2 的新型适配体的抗肿瘤潜力
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2680
Samet Uçak, Fulya Küçükcankurt, Nedret Altiok
{"title":"Theranostic potential of a novel aptamer specifically targeting HER2 in breast cancer cells","authors":"Samet Uçak, Fulya Küçükcankurt, Nedret Altiok","doi":"10.55730/1300-0152.2680","DOIUrl":"https://doi.org/10.55730/1300-0152.2680","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p CircRNA LDLR 通过 miR-449b-5p 靶向 CHD1 促进胃癌细胞增殖和有氧糖酵解
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2681
Fanye Zeng, JunTao Zhao, MengTing Tong, WenTing He, Nan Li, YuXiang Fan, YanHua Zhu, LiPing Zhang, HongLiang Zhang
{"title":"CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p","authors":"Fanye Zeng, JunTao Zhao, MengTing Tong, WenTing He, Nan Li, YuXiang Fan, YanHua Zhu, LiPing Zhang, HongLiang Zhang","doi":"10.55730/1300-0152.2681","DOIUrl":"https://doi.org/10.55730/1300-0152.2681","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140424921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Divergent Proteomic Profiles of Opium Poppy Cultivars 罂粟栽培品种的不同蛋白质组图谱
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2684
Setenay Aykanat, Mine Türktaş
{"title":"Divergent Proteomic Profiles of Opium Poppy Cultivars","authors":"Setenay Aykanat, Mine Türktaş","doi":"10.55730/1300-0152.2684","DOIUrl":"https://doi.org/10.55730/1300-0152.2684","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beneficial effects of a novel polyherbal formulation on the skeletal muscle antioxidant status, inflammation, and muscle-signaling proteins in exercised rats 新型多草药配方对运动大鼠骨骼肌抗氧化状态、炎症和肌肉信号蛋白的有益影响
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2682
Mehmet Tuzcu, Oğuzhan Özdemi̇r, C. Orhan, N. Şahin, Abhijeet Morde, M. Padigaru, P. Bhanuse, K. Şahin
{"title":"Beneficial effects of a novel polyherbal formulation on the skeletal muscle antioxidant status, inflammation, and muscle-signaling proteins in exercised rats","authors":"Mehmet Tuzcu, Oğuzhan Özdemi̇r, C. Orhan, N. Şahin, Abhijeet Morde, M. Padigaru, P. Bhanuse, K. Şahin","doi":"10.55730/1300-0152.2682","DOIUrl":"https://doi.org/10.55730/1300-0152.2682","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of thymol on oxidative stress and reelin signaling pathway in Alzheimer's disease model 百里酚对阿尔茨海默病模型中氧化应激和缰绳蛋白信号通路的影响
IF 2.2 4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2024-02-27 DOI: 10.55730/1300-0152.2683
Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi
{"title":"Effect of thymol on oxidative stress and reelin signaling pathway in Alzheimer's disease model","authors":"Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi","doi":"10.55730/1300-0152.2683","DOIUrl":"https://doi.org/10.55730/1300-0152.2683","url":null,"abstract":"","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ribosomal protein L8 regulates the expression and splicing pattern of genes associated with cancer-related pathways 核糖体蛋白L8调节与癌症相关途径相关基因的表达和剪接模式
4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2023-10-18 DOI: 10.55730/1300-0152.2666
LEILEI XU, GUI YANG, BIN SONG, DONG CHEN, Akbar. Yunus, JIANGTAO CHEN, XIAOGANG YANG, ZHENG TIAN
Background/aim: Ribosomal proteins have been shown to perform unique extraribosomal functions in cell apoptosis and other biological processes. Ribosomal protein L8 (RPL8) not only has important nonribosomal regulatory functions but also participates in the oncogenesis and development of tumors. However, the specific biological functions and pathways involved in this process are still unknown. Materials and methods: RPL8 was overexpressed (RPL8-OE) in HeLa cells. MTT assay and flow cytometry were used to detect cell proliferation and apoptosis, respectively. Transcriptome sequencing was performed to analyze the differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs) by RPL8-OE, both of which were validated by quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay. Results: RPL8-OE inhibited cell proliferation and promoted cell apoptosis. RPL8 regulated the differential expression of many oncogenic genes and the occurrence of RASEs. Many DEGs and RASE genes (RASGs) were enriched in tumorigenesis and tumor progressionrelated pathways, including angiogenesis, inflammation, and regulation of cell proliferation. RPL8 could regulate the RASGs enriched in the negative regulation of apoptosis, consistent with its proapoptosis function. Furthermore, RPL8 may influence cancer-related DEGs by modulating the alternative splicing of transcription factors. Conclusion: RPL8 might affect the phenotypes of cancer cells by altering the transcriptome profiles, including gene expression and splicing, which provides novel insights into the biological functions of RPL8 in tumor development.
背景/目的:核糖体蛋白在细胞凋亡和其他生物过程中具有独特的核糖体外功能。核糖体蛋白L8 (RPL8)不仅具有重要的非核糖体调控功能,还参与肿瘤的发生发展。然而,这一过程所涉及的具体生物学功能和途径尚不清楚。材料与方法:RPL8在HeLa细胞中过表达(RPL8- oe)。MTT法检测细胞增殖,流式细胞术检测细胞凋亡。通过转录组测序分析差异表达基因(DEGs)和RPL8-OE调控的选择性剪接事件(RASEs),并通过定量逆转录聚合酶链反应(RT-qPCR)验证。结果:RPL8-OE抑制细胞增殖,促进细胞凋亡。RPL8调控多种致癌基因的差异表达和RASEs的发生。许多deg和RASE基因(rasg)在肿瘤发生和肿瘤进展相关途径中富集,包括血管生成、炎症和细胞增殖调节。RPL8可调控富集负调控凋亡的rasg,与其促凋亡功能一致。此外,RPL8可能通过调节转录因子的选择性剪接来影响癌症相关的基因突变。结论:RPL8可能通过改变转录组谱,包括基因表达和剪接来影响癌细胞的表型,这为RPL8在肿瘤发生中的生物学功能提供了新的见解。
{"title":"Ribosomal protein L8 regulates the expression and splicing pattern of genes associated with cancer-related pathways","authors":"LEILEI XU, GUI YANG, BIN SONG, DONG CHEN, Akbar. Yunus, JIANGTAO CHEN, XIAOGANG YANG, ZHENG TIAN","doi":"10.55730/1300-0152.2666","DOIUrl":"https://doi.org/10.55730/1300-0152.2666","url":null,"abstract":"Background/aim: Ribosomal proteins have been shown to perform unique extraribosomal functions in cell apoptosis and other biological processes. Ribosomal protein L8 (RPL8) not only has important nonribosomal regulatory functions but also participates in the oncogenesis and development of tumors. However, the specific biological functions and pathways involved in this process are still unknown. Materials and methods: RPL8 was overexpressed (RPL8-OE) in HeLa cells. MTT assay and flow cytometry were used to detect cell proliferation and apoptosis, respectively. Transcriptome sequencing was performed to analyze the differentially expressed genes (DEGs) and regulated alternative splicing events (RASEs) by RPL8-OE, both of which were validated by quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay. Results: RPL8-OE inhibited cell proliferation and promoted cell apoptosis. RPL8 regulated the differential expression of many oncogenic genes and the occurrence of RASEs. Many DEGs and RASE genes (RASGs) were enriched in tumorigenesis and tumor progressionrelated pathways, including angiogenesis, inflammation, and regulation of cell proliferation. RPL8 could regulate the RASGs enriched in the negative regulation of apoptosis, consistent with its proapoptosis function. Furthermore, RPL8 may influence cancer-related DEGs by modulating the alternative splicing of transcription factors. Conclusion: RPL8 might affect the phenotypes of cancer cells by altering the transcriptome profiles, including gene expression and splicing, which provides novel insights into the biological functions of RPL8 in tumor development.","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial transplantation and transfer: The promising method for diseases 线粒体移植和转移:治疗疾病的有前途的方法
4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2023-10-18 DOI: 10.55730/1300-0152.2665
GÖKHAN BURÇİN KUBAT
Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.
线粒体是真核细胞中提供细胞生物能量的细胞器。它负责线粒体三磷酸腺苷(ATP)的产生、细胞信号传导和活性、钙平衡、细胞存活、增殖、凋亡和自噬。线粒体移植是一种很有前途的疾病治疗方法,涉及使用分离的功能线粒体恢复线粒体功能障碍。本文的目的是提供有关天然线粒体转移过程的最新知识,线粒体移植的体外和体内应用,临床试验以及与线粒体移植相关的挑战。
{"title":"Mitochondrial transplantation and transfer: The promising method for diseases","authors":"GÖKHAN BURÇİN KUBAT","doi":"10.55730/1300-0152.2665","DOIUrl":"https://doi.org/10.55730/1300-0152.2665","url":null,"abstract":"Mitochondria are organelles that serve as the powerhouses for cellular bioenergetics in eukaryotic cells. It is responsible for mitochondrial adenosine triphosphate (ATP) generation, cell signaling and activity, calcium balance, cell survival, proliferation, apoptosis, and autophagy. Mitochondrial transplantation is a promising disease therapy that involves the recovery of mitochondrial dysfunction using isolated functioning mitochondria. The objective of the present article is to provide current knowledge on natural mitochondrial transfer processes, in vitro and in vivo applications of mitochondrial transplantation, clinical trials, and challenges associated with mitochondrial transplantation.","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gooseberry anthocyanins alleviate insulin resistance by regulating ceramide metabolism in high fat diet mice 醋栗花青素通过调节神经酰胺代谢减轻高脂饮食小鼠的胰岛素抵抗
4区 生物学 Q1 Agricultural and Biological Sciences Pub Date : 2023-10-18 DOI: 10.55730/1300-0152.2668
XIAN TANG, JUN GAO, JINPENG HUANG, CHENJUAN ZHANG, HONGWEI LIU, JIE WEI
Background/aim: Obesity is the fifth largest risk factor of death in the world. The ceramide produced by obesity is closely related to insulin resistance (IR) caused by obesity. At present, the commercially available weight loss products have large side effects and limited therapeutic effects. Therefore, it is particularly important to find effective natural nontoxic products to treat obesity and explore its possible pathways and mechanisms. Materials and methods: In this paper, a high-fat diet (HFD) mice model was established by intragastric administration of high-fat emulsion to investigate the intervention effect of Gooseberry anthocyanins (GA) on IR in HFD mice. We used molecular docking technology to find the binding sites and binding energy of anthocyanins on CerS6. Real-time PCR was used to detect the effect of GA on the expression of IL-6 and TNF-α mRNA in HFD mice. The expression of S1P/Cer signaling pathway in HFD mice with IR was detected by Western Blot. Results: The results showed that GA could effectively inhibit visceral fat, liver index, the level of TC, TG and the level of LDL-C (p < 0.05), and improved HDL-C, GSH-Px and SOD (p < 0.05). GA decreased the level of insulin sensitivity index from -5.15 to -4.54 and improved insulin sensitivity and IR in HFD mice. The binding energy of anthocyanins on CerS6 was in the range of -8.2 to 5.2 kcal/ mol, with low energy parameters and good binding positions. GA could reduce mRNA levels of inflammatory factors IL-6 and TNF-α (p < 0.05), inhibit the expression of CerS6, PKCζ, PPARγ, CD36 (p < 0.05), and enhance the expression of SphK2, Akt, p-Akt/Akt, ISR (p < 0.05). Conclusion: This study investigated the effect and mechanism of GA on reducing ceramide content and reducing IR in mice, and provided an experimental basis for the prevention and treatment of obesity-related diseases.
背景/目的:肥胖是世界上第五大死亡危险因素。肥胖产生的神经酰胺与肥胖引起的胰岛素抵抗(insulin resistance, IR)密切相关。目前市面上的减肥产品副作用大,治疗效果有限。因此,寻找有效的天然无毒药物治疗肥胖并探索其可能的途径和机制就显得尤为重要。材料与方法:采用高脂乳灌胃法建立高脂饮食小鼠模型,研究醋栗花青素(GA)对高脂饮食小鼠IR的干预作用。我们利用分子对接技术找到了花青素在CerS6上的结合位点和结合能。采用Real-time PCR检测GA对HFD小鼠IL-6和TNF-α mRNA表达的影响。Western Blot检测S1P/Cer信号通路在HFD小鼠IR中的表达。结果:GA能有效抑制内脏脂肪、肝脏指数、TC、TG、LDL-C水平(p < 0.05),提高HDL-C、GSH-Px、SOD水平(p < 0.05)。GA使HFD小鼠的胰岛素敏感性指数从-5.15降至-4.54,并改善胰岛素敏感性和IR。花青素在CerS6上的结合能在-8.2 ~ 5.2 kcal/ mol之间,具有较低的能量参数和良好的结合位置。GA可降低炎症因子IL-6、TNF-α mRNA水平(p < 0.05),抑制CerS6、PKCζ、PPARγ、CD36的表达(p < 0.05),提高SphK2、Akt、p-Akt/Akt、ISR的表达(p < 0.05)。结论:本研究探讨了GA降低小鼠神经酰胺含量、降低IR的作用及其机制,为肥胖相关疾病的防治提供了实验依据。
{"title":"Gooseberry anthocyanins alleviate insulin resistance by regulating ceramide metabolism in high fat diet mice","authors":"XIAN TANG, JUN GAO, JINPENG HUANG, CHENJUAN ZHANG, HONGWEI LIU, JIE WEI","doi":"10.55730/1300-0152.2668","DOIUrl":"https://doi.org/10.55730/1300-0152.2668","url":null,"abstract":"Background/aim: Obesity is the fifth largest risk factor of death in the world. The ceramide produced by obesity is closely related to insulin resistance (IR) caused by obesity. At present, the commercially available weight loss products have large side effects and limited therapeutic effects. Therefore, it is particularly important to find effective natural nontoxic products to treat obesity and explore its possible pathways and mechanisms. Materials and methods: In this paper, a high-fat diet (HFD) mice model was established by intragastric administration of high-fat emulsion to investigate the intervention effect of Gooseberry anthocyanins (GA) on IR in HFD mice. We used molecular docking technology to find the binding sites and binding energy of anthocyanins on CerS6. Real-time PCR was used to detect the effect of GA on the expression of IL-6 and TNF-α mRNA in HFD mice. The expression of S1P/Cer signaling pathway in HFD mice with IR was detected by Western Blot. Results: The results showed that GA could effectively inhibit visceral fat, liver index, the level of TC, TG and the level of LDL-C (p < 0.05), and improved HDL-C, GSH-Px and SOD (p < 0.05). GA decreased the level of insulin sensitivity index from -5.15 to -4.54 and improved insulin sensitivity and IR in HFD mice. The binding energy of anthocyanins on CerS6 was in the range of -8.2 to 5.2 kcal/ mol, with low energy parameters and good binding positions. GA could reduce mRNA levels of inflammatory factors IL-6 and TNF-α (p < 0.05), inhibit the expression of CerS6, PKCζ, PPARγ, CD36 (p < 0.05), and enhance the expression of SphK2, Akt, p-Akt/Akt, ISR (p < 0.05). Conclusion: This study investigated the effect and mechanism of GA on reducing ceramide content and reducing IR in mice, and provided an experimental basis for the prevention and treatment of obesity-related diseases.","PeriodicalId":23358,"journal":{"name":"Turkish Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135943716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Turkish Journal of Biology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1