Neoadjuvant Chemotherapy, Carboplatin, and Paclitaxel in Pregnancy of a 22-Year Old with Stage IIA2 Cervical Cancer

Abstract

Cervical cancer is the second most common cancer found in pregnant women at a young age. Neoadjuvant with carboplatin and paclitaxel is often given to patients with cervical cancer, but the experience of administration during pregnancy is very limited. A 22-year-old woman was diagnosed with stage IIA2 cervical cancer at 26 weeks gestation. Patients received three medications, including neoadjuvant chemotherapy, carboplatin, paclitaxel, in three cycles with three weeks intervals at 27 weeks gestation. The patient underwent a pregnancy termination with emergency cesarean delivery at 36 weeks of gestation and continued with a hysterectomy radical 60 days, after which the patient received a chemoradiation adjuvant. Mother and baby are healthy one year after diagnosis. Neoadjuvant chemotherapy with carboplatin and paclitaxel can prevent progression of the disease and is safe for pregnant women and fetal in early stage cervical cancer in young age continued with delay radical hysterectomy.