Expressions of human epidermal growth factor receptor 2 in recurrent patients after radical gastrectomy and its significance

Q4 Medicine 肿瘤研究与临床 Pub Date : 2020-03-28 DOI:10.3760/CMA.J.CN115355-20191107-00506

Ling Chen, Jing Lin, Xiaojie Wang, Yu Chen, Lizhu Chen, Zengqing Guo, Jia-mi Yu

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Abstract

Objective To investigate the expressions of human epidermal growth factor receptor 2 (HER2) in recurrent patients after radical gastrectomy and its correlation with clinicopathologic features and prognosis. Methods The clinical data of 116 recurrent patients after radical gastrectomy between December 2011 and March 2019 in Fujian Cancer Hospital were retrospectively analyzed. The relationship between HER2 expression of the tissues after radical gastrectomy and clinicopathological features as well as prognosis was also analyzed. Results HER2 positive rate was 19.8% (23/116) in gastric cancer specimens of 116 patients after radical gastrectomy. HER2 positive rate in highly and moderately differentiated patients with gastric cancer was higher than that in those with poorly differentiated gastric cancer [33.3% (11/33) vs. 14.5% (12/83), χ2 = 5.292, P 0.05). HER2 expression was not associated with disease-free survival time (P > 0.05). Conclusion HER2 expression is associated with the differentiation degree of gastric cancer and the location of distant metastasis, but it can not be used as a predictor for recurrence of gastric cancer. Key words: Stomach neoplasms; Human epidermal growth factor receptor 2; Clinicopathologic features; Prognosis

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人表皮生长因子受体2在胃癌根治术后复发患者中的表达及其意义

目的探讨人表皮生长因子受体2 (HER2)在胃癌根治术后复发患者中的表达及其与临床病理及预后的关系。方法回顾性分析2011年12月至2019年3月福建省肿瘤医院116例胃癌根治术后复发患者的临床资料。分析胃癌根治术后组织中HER2表达与临床病理特征及预后的关系。结果116例胃癌根治术后标本中HER2阳性率为19.8%(23/116)。高、中分化胃癌患者HER2阳性率高于低分化胃癌患者[33.3%(11/33)比14.5% (12/83)，χ2 = 5.292, p0.05]。HER2表达与无病生存时间无相关性(P < 0.05)。结论HER2表达与胃癌分化程度及远处转移部位有关，但不能作为胃癌复发的预测指标。关键词:胃肿瘤;人表皮生长因子受体2;临床病理的功能;预后

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