Mucoadhesive polymeric systems for vaginal drug delivery: a systemic review

Q4 Engineering Revista Mexicana de Ingenieria Biomedica Pub Date : 2023-07-31 DOI:10.17488/rmib.44.2.4

Maryel Hernández-González, C. Rodríguez-González, J. Hernández-Paz, I. Olivas-Armendáriz

{"title":"Mucoadhesive polymeric systems for vaginal drug delivery: a systemic review","authors":"Maryel Hernández-González, C. Rodríguez-González, J. Hernández-Paz, I. Olivas-Armendáriz","doi":"10.17488/rmib.44.2.4","DOIUrl":null,"url":null,"abstract":"Intravaginal drug administration has many advantages in comparison to other delivery routes: its local and systemic effect, lower dosages, and easiness of administration. Furthermore, makes it a reliable and comfortable way of therapy. This route can be used to prevent and treat a wide range of conditions including, sexually transmitted infections (STIs), hormonal treatment, birth control, and cancer treatment. The dosage forms may vary from ovules, tablets, rings, gels, creams, films and many more; lately adding the mucoadhesiveness to the characteristics to reduce the waste of active molecules. This review focuses on the way mucoadhesive polymeric systems have been applied in vaginal delivery. This review presents a bibliographical compilation of results from various investigations published in scientific databases: Science Direct, SciELO, and PubMed Central. Results compiled demonstrate that the intravaginal drug administration can be an alternative form of medication for women with more stable and prolonged results than traditional routes requiring lower doses and avoiding the first-pass effect.","PeriodicalId":38670,"journal":{"name":"Revista Mexicana de Ingenieria Biomedica","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Mexicana de Ingenieria Biomedica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17488/rmib.44.2.4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Engineering","Score":null,"Total":0}

引用次数: 0

Abstract

Intravaginal drug administration has many advantages in comparison to other delivery routes: its local and systemic effect, lower dosages, and easiness of administration. Furthermore, makes it a reliable and comfortable way of therapy. This route can be used to prevent and treat a wide range of conditions including, sexually transmitted infections (STIs), hormonal treatment, birth control, and cancer treatment. The dosage forms may vary from ovules, tablets, rings, gels, creams, films and many more; lately adding the mucoadhesiveness to the characteristics to reduce the waste of active molecules. This review focuses on the way mucoadhesive polymeric systems have been applied in vaginal delivery. This review presents a bibliographical compilation of results from various investigations published in scientific databases: Science Direct, SciELO, and PubMed Central. Results compiled demonstrate that the intravaginal drug administration can be an alternative form of medication for women with more stable and prolonged results than traditional routes requiring lower doses and avoiding the first-pass effect.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

用于阴道给药的粘膜粘附聚合物系统：系统综述

与其他给药途径相比，阴道内给药有许多优点：其局部和全身效果、较低的剂量和易于给药。此外，使其成为一种可靠且舒适的治疗方式。这种途径可用于预防和治疗多种疾病，包括性传播感染（STIs）、激素治疗、计划生育和癌症治疗。剂型可能因胚珠、片剂、环、凝胶、乳膏、薄膜等而异；最近将粘性添加到特性中以减少活性分子的浪费。这篇综述的重点是粘膜粘合剂聚合物系统在阴道分娩中的应用。这篇综述提供了科学数据库中发表的各种调查结果的目录汇编：Science Direct、SciELO和PubMed Central。汇编的结果表明，阴道内给药可以成为女性的一种替代药物形式，与需要较低剂量并避免首次通过效应的传统途径相比，效果更稳定、更持久。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Revista Mexicana de Ingenieria Biomedica Engineering-Biomedical Engineering

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： La Revista Mexicana de Ingeniería Biomédica (The Mexican Journal of Biomedical Engineering, RMIB, for its Spanish acronym) is a publication oriented to the dissemination of papers of the Mexican and international scientific community whose lines of research are aligned to the improvement of the quality of life through engineering techniques. The papers that are considered for being published in the RMIB must be original, unpublished, and first rate, and they can cover the areas of Medical Instrumentation, Biomedical Signals, Medical Information Technology, Biomaterials, Clinical Engineering, Physiological Models, and Medical Imaging as well as lines of research related to various branches of engineering applied to the health sciences.