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Neuromarkers based on EEG Statistics in Time and Frequency Domains to Detect Tinnitus 基于脑电图时域和频域统计的神经标志物检测耳鸣
Q4 Engineering Pub Date : 2023-09-01 DOI: 10.17488/rmib.44.3.1
Ricardo A. Salido-Ruiz, Sulema Torres-Ramos, Aurora Espinoza-Valdez, Luz María Alonso-Valerdi, Israel Román-Godínez, David I. Ibarra-Zarate
Tinnitus detection and characterization requires a carefully elaborated diagnosis mainly owing to its heterogeneity nature. The present investigation aims to find features in Electroencephalographic (EEG) signals from time and frequency domain analysis that could distinguish between healthy and tinnitus sufferers with different levels of hearing loss. For this purpose, 24 volunteers were recruited and equally divided into four groups: 1) controls, 2) slow tinnitus, 3) middle tinnitus and 4) high tinnitus. EEG signals were registered in two states, with eyes closed and opened for 60 seconds. EEG analysis was focused on two bandwidths: delta and alpha band. For time domain, the EEG features estimated were mean, standard deviation, kurtosis, maximum peak, skewness and shape. For frequency domain, the EEG features obtained were mean, skewness, power spectral density. Normality of EEG data was evaluated by the Lilliefors test, and as a result, the nonparametric technique Kruskal-Wallis H statistic to test significance was applied. Results show that EEG features are more differentiable between tinnitus sufferers and controls in frequency domain than in time domain. EEG features from tinnitus patients with high HL are significantly different from the rest of the groups in alpha frequency band activity when shape and skewness are computed.
耳鸣的检测和表征需要仔细阐述诊断,主要是由于其异质性。本研究旨在从脑电图信号的时域和频域分析中寻找能够区分不同程度听力损失的健康人与耳鸣患者的特征。为此,招募了24名志愿者,将他们平均分为四组:1)对照组,2)慢耳鸣组,3)中度耳鸣组,4)重度耳鸣组。脑电图信号记录在两种状态下,闭上眼睛和睁开眼睛60秒。脑电图分析集中在两个带宽:δ和α波段。在时域上,估计的脑电信号特征包括均值、标准差、峰度、最大峰、偏度和形状。在频域,得到的脑电信号特征包括均值、偏度、功率谱密度。采用Lilliefors检验评价脑电数据的正态性,并采用非参数技术Kruskal-Wallis H统计量检验显著性。结果表明,耳鸣患者和对照组的脑电图特征在频域上比在时域上更容易区分。当计算形状和偏度时,高HL耳鸣患者的脑电图特征在α频带活动上与其他组有显著差异。
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引用次数: 0
Comparison of Spectral and Sparse Feature Extraction Methods for Heart Sounds Classification 频谱与稀疏特征提取方法在心音分类中的比较
Q4 Engineering Pub Date : 2023-08-17 DOI: 10.17488/rmib.44.4.1
Roilhi Frajo Ibarra Hernández, Miguel A. Alonso-Arévalo, E. García-Canseco
Cardiovascular diseases (CVDs) remain the leading cause of morbidity worldwide. The heart sound signal or phonocardiogram (PCG) is the most simple, low-cost, and effective tool to assist physicians in diagnosing CVDs. Advances in signal processing and machine learning have motivated the design of computer-aided systems for heart illness detection based only on the PCG. The objective of this work is to compare the effects of using spectral and sparse features for a classification scheme to detect the presence/absence of a pathological state in a heart sound signal, more specifically, sparse representations using Matching Pursuit with multiscale Gabor time-frequency dictionaries, linear prediction coding, and Mel-frequency cepstral coefficients. This work compares the performance of PCGs classification applying features as a result of averaging the samples or the features for each PCG sound event when feeding a random forest (RF) classifier. For data balancing, random under-sampling and synthetic minority oversampling (SMOTE) methods were applied. Furthermore, we compare the Correlation Feature Selection (CFS) and Information Gain (IG) for the dimensionality reduction. The findings show a SE=93.17 %, SP=84.32 % and ACC=85.9 % when joining MP+LPC+MFCC features set with an AUC=0.969 showing that these features are promising to be used in heart sounds anomaly detection schemes.
心血管疾病(cvd)仍然是世界范围内发病率的主要原因。心音信号或心音图(PCG)是帮助医生诊断心血管疾病最简单、低成本和有效的工具。信号处理和机器学习的进步推动了基于PCG的心脏病检测计算机辅助系统的设计。这项工作的目的是比较使用频谱和稀疏特征作为分类方案来检测心音信号中存在/不存在病理状态的效果,更具体地说,使用匹配追踪的稀疏表示与多尺度Gabor时频字典、线性预测编码和mel -频率倒谱系数。这项工作比较了在输入随机森林(RF)分类器时对每个PCG声音事件的样本或特征进行平均的结果,即PCG分类应用特征的性能。对于数据平衡,采用随机欠采样和合成少数过采样(SMOTE)方法。此外,我们比较了相关特征选择(CFS)和信息增益(IG)的降维效果。结果表明,MP+LPC+MFCC特征集的SE= 93.17%, SP= 84.32%, ACC= 85.9%, AUC=0.969,表明这些特征有望用于心音异常检测方案。
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引用次数: 0
Mucoadhesive polymeric systems for vaginal drug delivery: a systemic review 用于阴道给药的粘膜粘附聚合物系统:系统综述
Q4 Engineering Pub Date : 2023-07-31 DOI: 10.17488/rmib.44.2.4
Maryel Hernández-González, C. Rodríguez-González, J. Hernández-Paz, I. Olivas-Armendáriz
Intravaginal drug administration has many advantages in comparison to other delivery routes: its local and systemic effect, lower dosages, and easiness of administration. Furthermore, makes it a reliable and comfortable way of therapy. This route can be used to prevent and treat a wide range of conditions including, sexually transmitted infections (STIs), hormonal treatment, birth control, and cancer treatment. The dosage forms may vary from ovules, tablets, rings, gels, creams, films and many more; lately adding the mucoadhesiveness to the characteristics to reduce the waste of active molecules. This review focuses on the way mucoadhesive polymeric systems have been applied in vaginal delivery. This review presents a bibliographical compilation of results from various investigations published in scientific databases: Science Direct, SciELO, and PubMed Central. Results compiled demonstrate that the intravaginal drug administration can be an alternative form of medication for women with more stable and prolonged results than traditional routes requiring lower doses and avoiding the first-pass effect.
与其他给药途径相比,阴道内给药有许多优点:其局部和全身效果、较低的剂量和易于给药。此外,使其成为一种可靠且舒适的治疗方式。这种途径可用于预防和治疗多种疾病,包括性传播感染(STIs)、激素治疗、计划生育和癌症治疗。剂型可能因胚珠、片剂、环、凝胶、乳膏、薄膜等而异;最近将粘性添加到特性中以减少活性分子的浪费。这篇综述的重点是粘膜粘合剂聚合物系统在阴道分娩中的应用。这篇综述提供了科学数据库中发表的各种调查结果的目录汇编:Science Direct、SciELO和PubMed Central。汇编的结果表明,阴道内给药可以成为女性的一种替代药物形式,与需要较低剂量并避免首次通过效应的传统途径相比,效果更稳定、更持久。
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引用次数: 0
Type of Feet in a Mexican Population: Analysis of the Footprint Morphology and Literature Review 墨西哥人群的足型:足印形态分析及文献综述
Q4 Engineering Pub Date : 2023-06-13 DOI: 10.17488/rmib.44.2.2
J. L. Ramírez-Reyes, D. Gaytán-Macías, H. Quintana-Camacho, G. Galicia Aguilar, G. González Mancera
Magnesium (Mg) is essential for the metabolic reactions of the human body and is known for its biocompatibility, its mechanical and physical properties are similar to human bone, which is why it is considered to have high potential in biomedical applications such as temporary and resorbable implants. Through surface modifications, the high tendency to corrosion of Mg could be controlled, such as biodegradable membranes that prevent the passage of chloride ions present in the human organism. To prepare the membrane, solutions of chitosan modified with gelatin and/or glutaraldehyde are used and by means of the electrospray method applied to protect the Mg. To simulate body fluid conditions a Kokubo saline solution (BFK) was prepared. The study focuses on evaluating the corrosion rate of Mg with a coating made of a chitosan electrosprayed membrane, applying electrochemical measurements of electrochemical impedance spectroscopy and linear polarization resistance. The key additive to improve the behavior of the membranes was observed with the use of gelatin, where the membrane with the best results lowing corrosion rates is the Mg CH+GE+GL system, which it was observed with very good physical integrity in the images of morphological analyzes of the surface after 30 days of exposure.
镁(Mg)对人体代谢反应至关重要,以其生物相容性、机械和物理性能与人体骨骼相似而闻名,这就是为什么它被认为在生物医学应用中具有很高的潜力,如临时和可吸收植入物。通过表面改性,可以控制镁的高腐蚀倾向,例如防止人体内氯离子通过的可生物降解膜。为了制备膜,使用明胶和/或戊二醛改性的壳聚糖溶液,并通过电喷雾法保护镁。为了模拟体液条件,制备了Kokubo盐水溶液(BFK)。本研究的重点是利用电化学阻抗谱和线极化电阻的电化学测量,评估壳聚糖电喷雾膜涂层对镁的腐蚀速率。使用明胶观察到改善膜性能的关键添加剂,其中降低腐蚀速率效果最好的膜是Mg-CH+GE+GL体系,在暴露30天后的表面形态分析图像中观察到该体系具有非常好的物理完整性。
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引用次数: 0
Type of Feet in a Mexican Population: Analysis of the Footprint Morphology and Literature Review 墨西哥人群的足型:足印形态分析及文献综述
Q4 Engineering Pub Date : 2023-05-01 DOI: 10.17488/rmib.44.2.1
J. A. Ramos-Frutos, I. Miguel-Andrés, M. León-Rodríguez, Luis Ángel Ortiz-Lango, S. Orozco-Villaseñor, A. Vidal-Lesso
The objective of this study was to analyze the footprint morphology and obtain the Chippaux-Smirak Index in a Mexican population to identify the type of feet and its prevalence. A database of images of the soles of both feet was analyzed. The database contained images of 1,014 persons between 2 and 73 years old from Guanajuato state, Mexico. Moreover, a literature review was performed to identify the type of feet in the Mexican population. It was observed that less than 17 % of the population have cavus foot (p= 0.018). Furthermore, less than 25 % of the population between 17 and 73 years have flatfoot 3 (p= 0.0079) in the left foot. Also, only nine articles related to the type of foot in the Mexican population were found, but most of them were performed on young population. The formation of the medial arc could be beyond the first decade of life and the relatively high prevalence of flatfoot in adult life should be studied. Finally, the results found can be useful for orthopedists, physiotherapists, clinicians, and parents who are concerned about the foot health of their children.
本研究的目的是分析足迹形态,并获得墨西哥人群中的Chippoux Smirak指数,以确定足部类型及其患病率。分析了一个包含脚底图像的数据库。该数据库包含来自墨西哥瓜纳华托州的1014名2至73岁人员的图像。此外,还进行了文献综述,以确定墨西哥人口的足部类型。据观察,只有不到17%的人群患有腔足(p=0.018)。此外,在17岁至73岁的人群中,左脚只有不到25%的人患有扁平足3型(p=0.0079)。此外,在墨西哥人群中只发现了9篇与足部类型有关的文章,但大多数都是在年轻人群中进行的。内侧弧的形成可能超过生命的第一个十年,应该研究平足在成年生活中相对较高的患病率。最后,研究结果对骨科医生、理疗师、临床医生和关心孩子足部健康的父母都很有用。
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引用次数: 0
Feasibility in the use of the UV-Visible region for the characterization of glucose in deionized water using Arduino 1 利用Arduino 1利用紫外可见区表征去离子水中葡萄糖的可行性
Q4 Engineering Pub Date : 2023-05-01 DOI: 10.17488/rmib.44.2.3
V. Sánchez-Monroy, Luis Enrique Barros-Martinez, Alejandro Hidalgo-Pedraza, Braulio Adriel Mendoza-Munguia, Miguel Sanchez-Brito
With an estimated approximately 2 million deaths per year, diabetes is one of the top 5 deadliest noncommunicable diseases globally. Although this disease is not fatal, the degradation of the patient's health due to a bad plan to control their glucose levels can have a fatal outcome. In order to lay the foundations for the development of a device that allows estimating glucose levels in some body fluid, we present the results obtained not only for the estimation of glucose in deionized water, but also describe the development and configuration of the created device. After analyzing 50 signals obtained from 5 different glucose concentrations, the feasibility of using the developed device for the analysis is evident, since, considering the K-Nearest Neighbors (KNN) algorithm, all the signals were associated correctly to the glucose group to which they belong.
据估计,每年约有200万人死亡,糖尿病是全球五大最致命的非传染性疾病之一。尽管这种疾病并不致命,但由于控制血糖水平的不良计划导致患者健康状况恶化可能会导致致命的后果。为了为开发一种可以估计某些体液中葡萄糖水平的设备奠定基础,我们不仅介绍了估计去离子水中葡萄糖的结果,还描述了所创建设备的开发和配置。在分析了从5种不同葡萄糖浓度获得的50个信号后,使用所开发的设备进行分析的可行性是显而易见的,因为考虑到K近邻(KNN)算法,所有信号都与它们所属的葡萄糖组正确关联。
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引用次数: 0
Neuroimaging Techniques for Neuroplasticity Quantification in Stroke Patients 脑卒中患者神经可塑性量化的神经影像学技术
Q4 Engineering Pub Date : 2023-05-01 DOI: 10.17488/rmib.44.2.5
Martín Emiliano Rodríguez-García, Norma Marín-Arriaga, Silvia Gabriel Macías-Arriaga, Bernardo Salazar-Cárdenas, Tania Ramírez-Rodríguez, Víctor Hugo Aparicio-Jiménez, Raquel Valdés-Cristerna, Jessica Cantillo-Negrete
Neuroimaging techniques provide relevant information of the functional and anatomical status of the human brain. This information is of particular importance when a pathology, like stroke, produces a brain injury. In stroke patients, it has been determined that neuroplasticity is the primary recovery mechanism of the lost motor function. Due to worldwide high prevalence, especially in developing countries, it is necessary to continue the research of the recovery mechanisms involved in this pathology. To this end, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) are two of the most used neuroimaging techniques. In stroke patients, fMRI allows the analysis of the neural activity produced by the execution of motor tasks, whereas DTI provides structural information of the brain anatomy. In this narrative review, multiple studies that employ these neuroimaging techniques for quantification of neuroplasticity changes in stroke patients after undergoing a neurorehabilitation program are presented. Better understanding of these neuroplasticity changes would allow researchers to design and provide more beneficial rehabilitation schemes to stroke patients.
神经成像技术提供了人类大脑功能和解剖状态的相关信息。当中风等病理导致脑损伤时,这一信息尤为重要。在脑卒中患者中,已经确定神经可塑性是运动功能丧失的主要恢复机制。由于世界范围内的高患病率,特别是在发展中国家,有必要继续研究与该病理有关的恢复机制。为此,功能磁共振成像(fMRI)和扩散张量成像(DTI)是两种最常用的神经成像技术。在中风患者中,fMRI允许分析由执行运动任务产生的神经活动,而DTI提供大脑解剖结构信息。在这篇叙述性综述中,介绍了多项研究,这些研究使用这些神经成像技术来量化脑卒中患者在接受神经康复计划后的神经可塑性变化。更好地了解这些神经可塑性的变化将使研究人员能够设计并为中风患者提供更有益的康复方案。
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引用次数: 1
Novel Studies in the Designs of Natural, Synthetic, and Compound Hydrogels with Biomedical Applications 具有生物医学应用的天然、合成和复合水凝胶设计的新研究
Q4 Engineering Pub Date : 2023-05-01 DOI: 10.17488/rmib.44.2.6
Claudia Gabriela Cuéllar Gaona, María Cristina Ibarra Alonso, Rosa Idala Narro Céspedes, María Maura Téllez Rosas, Ricardo Reyna Martínez, Miriam Paulina Luévanos Escareño
Hydrogels are gaining widespread popularity in the biomedical field due to their extraordinary properties, such as biocompatibility, biodegradability, zero toxicity, easy processing, and similarity to physiological tissue. They have applications in controlled drug release, wound dressing, tissue engineering, and regenerative medicine. Among these applications, hydrogels as a controlled drug delivery system stands out, which releases active substances in precise amounts and at specific times. To explore the latest advances in the design of hydrogels, a literature review of articles published in indexed scientific journals, in Scopus and Science Direct, was carried out. This review aimed to discover and describe the most innovative hydrogel research with applications in the biomedical field; hydrogels synthesized with polymers of different origins were selected, such as; i. Natural (dextran, agarose, chitosan, etc.); ii. Synthetic (polyacrylamide, polyethylene glycol, polyvinyl alcohol, etc.); iii. Composites (interpenetrants, hybrid crosslinkers, nanocomposites, etc.). Comparative analysis revealed that hydrogels with composite materials show the most promise. These composite hydrogels combine the advantages of different polymers or incorporate additional components, offering enhanced properties and functionalities. In summary, hydrogels are versatile biomaterials with immense potential in biomedicine. Their unique properties make them suitable for diverse applications. However, innovative designs and formulations must continue to be explored to further advance the capabilities of hydrogels and expand their biomedical applications.
水凝胶由于其非凡的特性,如生物相容性、生物降解性、零毒性、易于加工以及与生理组织相似,在生物医学领域越来越受欢迎。它们在药物控制释放、伤口敷料、组织工程和再生医学中有应用。在这些应用中,水凝胶作为一种可控的药物递送系统脱颖而出,它能在特定时间精确释放活性物质。为了探索水凝胶设计的最新进展,对Scopus和Science Direct索引科学期刊上发表的文章进行了文献综述。这篇综述旨在发现和描述在生物医学领域应用的最具创新性的水凝胶研究;选择了由不同来源的聚合物合成的水凝胶,例如;i.天然(葡聚糖、琼脂糖、壳聚糖等);ii。合成(聚丙烯酰胺、聚乙二醇、聚乙烯醇等);iii.复合材料(互穿剂、杂化交联剂、纳米复合材料等)。比较分析表明,水凝胶与复合材料最有前景。这些复合水凝胶结合了不同聚合物的优点或加入了额外的成分,提供了增强的性能和功能。总之,水凝胶是一种在生物医学中具有巨大潜力的多功能生物材料。它们独特的特性使其适用于各种应用。然而,必须继续探索创新的设计和配方,以进一步提高水凝胶的能力并扩大其生物医学应用。
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引用次数: 0
Design of Exercise Device for Older Adults 老年人运动器材的设计
Q4 Engineering Pub Date : 2023-02-06 DOI: 10.17488/rmib.44.1.1
Daniel Gallegos Barría, Belkys Amador Cáceres, Gabriela Martínez Bordes, Mauricio San Martín Correa
Older adults should perform physical activity to improve cardiorespiratory functions. Aerobic exercises improve cardiovascular function, decrease basal heart rate and blood pressure, and improve mood and energy. To facilitate the execution of aerobic physical activity in older adults, the objective of this research was to design an exercise device for older adults. Starting from design specifications such as comfort, size, weight, resistance, and cost, we developed the detailed design of a horizontal bicycle. The designed device, thanks to its horizontally disposed structure, its adequate resistance to pedaling, its dimensioning based on anthropometric measurements of the Chilean population, and the disposition of sensors for heart rate and oxygen saturation, is suitable for older adults. Its weight and size also make it convenient for use inside the home, and the use of materials, components, and manufacturing processes available nationally and within the cheapest options, increases the possibility of access by older adults.
老年人应该进行体育锻炼以改善心肺功能。有氧运动可以改善心血管功能,降低基础心率和血压,改善情绪和精力。为了促进老年人进行有氧运动,本研究的目的是为老年人设计一种运动装置。从舒适性、尺寸、重量、阻力、成本等设计指标出发,进行了卧式自行车的详细设计。该设计的设备,由于其水平配置的结构,其足够的阻力踏板,其尺寸基于智利人口的人体测量测量,以及心率和氧饱和度传感器的配置,适合老年人。它的重量和尺寸也使其便于在家中使用,并且使用了国内可用的材料、部件和制造工艺,并且是最便宜的选择,增加了老年人使用的可能性。
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引用次数: 0
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Revista Mexicana de Ingenieria Biomedica
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