Angiopoietin-like protein 5: a potential culprit of cardio-metabolic risk in Egyptian obese children

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Egyptian Pharmaceutical Journal Pub Date : 2023-04-01 DOI:10.4103/epj.epj_168_22
Mai ElShiekh, Ghada M. El-Kassas, Maged A. El Wakeel, Dina Zaki, Hanan Atta, Dina Mostafa, S. El-Zayat, G. Elsawy
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Abstract

Background Obesity has recently been identified as a risk factor for coronavirus disease-19. There is a significant correlation between obesity rates with metabolic syndrome and coronavirus disease-19 in children worldwide. Owing to the high expression in adipose tissue, angiopoietin-like protein 5 (ANGPTL5) might be assumed to have a broad range of physiological processes in lipid, glucose homeostasis, and inflammatory responses. Objective To examine the association between childhood obesity and plasma ANGPTL5 levels in an attempt to demonstrate the probable relationships of plasma levels of ANGPTL5 with unacylated ghrelin and obestatin and its relevance to metabolic parameters in obese versus normal-weight children and adolescents. Patients and methods A total of 90 children between 5 and 15 years of age were randomly enrolled in this cross-sectional case–control study. They were classified into obese patients (n=45) and nonobese controls (n=45). BMI for age was calculated following WHO guidelines. Serum levels of ANGPTL5, obestatin, and unacylated ghrelin were measured and correlated with the anthropometric measurements and biochemical markers of metabolic syndrome. Results A highly significant positive correlation was observed between the serum level of ANGPTL5 and the weight z score. Moreover, a significant positive correlation between ANGPTL5 and the investigated diabetic parameters (glucose, insulin, and homeostasis model assessment for insulin resistance) and high sensitivity C-reactive protein was detected. The increased weight in children was associated with a higher level of ANGPTL5 in parallel with the observed elevated insulin resistance. Conclusion ANGPTL5 might be considered a promising sensitive assessment biomarker to be applied for early diagnosis and prognosis of obese children with a high risk of cardio-metabolic diseases.
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血管生成素样蛋白5:埃及肥胖儿童心脏代谢风险的潜在罪魁祸首
背景肥胖最近被确定为冠状病毒疾病的危险因素19。全球儿童肥胖率与代谢综合征和冠状病毒疾病19之间存在显著相关性。由于在脂肪组织中的高表达,血管生成素样蛋白5(ANGPTL5)可能被认为在脂质、葡萄糖稳态和炎症反应中具有广泛的生理过程。目的研究儿童肥胖与血浆ANGPTL5水平之间的关系,试图证明血浆ANGPTL6水平与未酰化胃饥饿素和奥贝他汀的可能关系,以及其与肥胖和正常体重儿童和青少年代谢参数的相关性。患者和方法共有90名5至15岁的儿童被随机纳入这项横断面病例对照研究。他们被分为肥胖患者(n=45)和非肥胖对照组(n=45%)。根据世界卫生组织指南计算年龄的BMI。测量血清ANGPTL5、奥贝他汀和未酰化胃饥饿素的水平,并将其与代谢综合征的人体测量和生化标志物相关联。结果血清ANGPTL5水平与体重z评分呈正相关。此外,ANGPTL5与所研究的糖尿病参数(葡萄糖、胰岛素和胰岛素抵抗的稳态模型评估)和高敏C反应蛋白之间存在显著的正相关。儿童体重增加与ANGPTL5水平升高有关,同时观察到胰岛素抵抗升高。结论ANGPTL5可能是一种很有前途的敏感评估生物标志物,可用于心脏代谢性疾病高危肥胖儿童的早期诊断和预后。
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来源期刊
Egyptian Pharmaceutical Journal
Egyptian Pharmaceutical Journal PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
0.00%
发文量
37
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