Metallo β- lactamase producing pseudomonas aeruginosa: a worrisome situation to handle

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Egyptian Pharmaceutical Journal Pub Date : 2023-07-01 DOI:10.4103/epj.epj_12_23
Manisha Rajguru, S. Sande, Amit Khekade
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Abstract

Pseudomonas aeruginosa is ubiquitous and very commonly found in hospital settings. In individuals with weakened immune systems, it can cause a number of ailments, inclusive of lung pneumoniae, gastrointestinal infections, keratitis, otitis media, and bacteremia. It is multi drug–resistant organism which is a worrisome situation. Multi-drug resistance is due to various factors like enzyme production, target mutation, expression of aminoglycoside-modifying enzymes (acetyltransferases, phosphotransferases) mediating aminoglycoside resistance, biofilm formation, but, among all of these, carbapenemases being one of most clinically significant. The most clinically significant carbapenemases are the Metallo β-lactamases (IMP, VIM, SPM, NDM, AIM and GIM genes). Understanding the epidemiology, resistance mechanism, molecular features, and for infection management and to prevent a potential global health crisis, techniques for identifying Carbapenem-Resistant-Pseudomonas aeruginosa (CRPA) are essential. For this review article, initial peer-review of publications from the various search engines (‘Google search engine’, ‘Science direct’, ‘Pubmed’, ‘Google Scholar’, ‘Cross references’ and ‘Scopus’) yielded a total of 97 papers. After reviewing the abstracts of the papers, 37 were eliminated and 60 were retained. Full text reading was undertaken to assess the quality of the articles, which resulted in the exclusion of 39 publications. After final peer-review screening, 17 publications were included in the study.
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金属β-内酰胺酶产生铜绿假单胞菌:一个令人担忧的情况处理
铜绿假单胞菌无处不在,在医院环境中很常见。在免疫系统较弱的个体中,它可以引起许多疾病,包括肺炎、胃肠道感染、角膜炎、中耳炎和菌血症。它是一种多重耐药菌,这是一个令人担忧的情况。多重耐药是由多种因素引起的,如酶的产生、靶点突变、介导氨基糖苷类修饰酶(乙酰转移酶、磷酸转移酶)的表达、生物膜的形成等,但其中碳青霉烯酶是临床上最重要的因素之一。临床意义最大的碳青霉烯酶是金属β-内酰胺酶(IMP、VIM、SPM、NDM、AIM和GIM基因)。了解流行病学,耐药机制,分子特征,感染管理和预防潜在的全球健康危机,鉴定碳青霉烯抗性铜绿假单胞菌(CRPA)的技术是必不可少的。在这篇综述文章中,对来自不同搜索引擎(“b谷歌搜索引擎”、“Science direct”、“Pubmed”、“谷歌Scholar”、“Cross references”和“Scopus”)的出版物进行初步同行评议,共产生97篇论文。在审查论文摘要后,37篇被淘汰,60篇被保留。全文阅读是为了评估文章的质量,结果排除了39份出版物。经过最终的同行评审筛选,17份出版物被纳入研究。
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来源期刊
Egyptian Pharmaceutical Journal
Egyptian Pharmaceutical Journal PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
0.00%
发文量
37
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