The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model

IF 0.9 4区 生物学 Q4 PLANT SCIENCES Israel Journal of Plant Sciences Pub Date : 2021-06-22 DOI:10.1163/22238980-bja10035
A. Telerman, Y. Kashman, R. Ofir, Anat Elmann
{"title":"The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model","authors":"A. Telerman, Y. Kashman, R. Ofir, Anat Elmann","doi":"10.1163/22238980-bja10035","DOIUrl":null,"url":null,"abstract":"\nPlant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima, a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNFα, IFNγ and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis.","PeriodicalId":14689,"journal":{"name":"Israel Journal of Plant Sciences","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2021-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Israel Journal of Plant Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1163/22238980-bja10035","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Plant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima, a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNFα, IFNγ and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
天然抗炎倍半萜内酯阿奇内酯A在小鼠模型中减少特应性皮炎
植物源性物质已被证明可以影响炎症性疾病的潜在靶点。我们之前已经从沙漠植物阿奇勒(Achillea fragrantissima)中纯化了一种倍半萜内酯,命名为阿奇勒内酯a,并在培养的脑巨噬细胞(小胶质细胞)中证明了其抗炎活性。在本研究中,我们进一步研究了阿喀琉斯内酯A在缓解特应性皮炎(一种慢性和复发性炎症性皮肤病)中的作用。我们利用恶唑酮致小鼠特应性皮炎模型研究阿基里斯内酯A的体内抗炎活性,在该模型中,恶唑酮引起耳肿胀。我们的研究结果表明,阿喀琉斯内酯A治疗小鼠的恶唑酮引起的耳部肿胀明显减少。由于巨噬细胞是在特应性皮炎发病过程中起关键作用的炎症细胞,因此我们也研究了阿基琉球内酯a在脾细胞中的抗炎作用。我们证明阿基里斯内酯A降低了lps诱导的炎性细胞因子IL-2、IL-6、TNFα、IFNγ和IL-12的水平,这些细胞由培养的脾细胞分泌。这些数据提示阿喀琉球内酯A在治疗特应性皮炎方面值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Israel Journal of Plant Sciences
Israel Journal of Plant Sciences 生物-植物科学
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: The Israel Journal of Plant Sciences is an international journal of extensive scope that publishes special issues dealing with all aspects of plant sciences, including but not limited to: physiology, cell biology, development, botany, genetic
期刊最新文献
Morphological and molecular diversity analysis vis-a-vis phylogenetic correlation among pomegranate (Punica granatum L.) varieties Morphological, structural, and ultrastructural key features of hyperhydricity in Beta vulgaris L. var. saccharifera Alternative products for breaking dormancy in ‘Reubennel’ plum in subtropical regions Evaluation of morpho-physiological and biochemical indicators of salinity stress in Argemone mexicana L., medicinal plant from Papaveraceae Effect of salt stress on morpho-physiological and anatomical attributes of Salix clones
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1