The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model

IF 0.9 4区 生物学 Q4 PLANT SCIENCES Israel Journal of Plant Sciences Pub Date : 2021-06-22 DOI:10.1163/22238980-bja10035
A. Telerman, Y. Kashman, R. Ofir, Anat Elmann
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Abstract

Plant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima, a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNFα, IFNγ and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis.
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天然抗炎倍半萜内酯阿奇内酯A在小鼠模型中减少特应性皮炎
植物源性物质已被证明可以影响炎症性疾病的潜在靶点。我们之前已经从沙漠植物阿奇勒(Achillea fragrantissima)中纯化了一种倍半萜内酯,命名为阿奇勒内酯a,并在培养的脑巨噬细胞(小胶质细胞)中证明了其抗炎活性。在本研究中,我们进一步研究了阿喀琉斯内酯A在缓解特应性皮炎(一种慢性和复发性炎症性皮肤病)中的作用。我们利用恶唑酮致小鼠特应性皮炎模型研究阿基里斯内酯A的体内抗炎活性,在该模型中,恶唑酮引起耳肿胀。我们的研究结果表明,阿喀琉斯内酯A治疗小鼠的恶唑酮引起的耳部肿胀明显减少。由于巨噬细胞是在特应性皮炎发病过程中起关键作用的炎症细胞,因此我们也研究了阿基琉球内酯a在脾细胞中的抗炎作用。我们证明阿基里斯内酯A降低了lps诱导的炎性细胞因子IL-2、IL-6、TNFα、IFNγ和IL-12的水平,这些细胞由培养的脾细胞分泌。这些数据提示阿喀琉球内酯A在治疗特应性皮炎方面值得进一步研究。
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来源期刊
Israel Journal of Plant Sciences
Israel Journal of Plant Sciences 生物-植物科学
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: The Israel Journal of Plant Sciences is an international journal of extensive scope that publishes special issues dealing with all aspects of plant sciences, including but not limited to: physiology, cell biology, development, botany, genetic
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