Rahma Nafiah, Y. Sumirtapura, S. T. Darijanto, M. Iwo
{"title":"Development of Forskolin Microemulsion Formula and its Irritation Test on Rabbits","authors":"Rahma Nafiah, Y. Sumirtapura, S. T. Darijanto, M. Iwo","doi":"10.4274/tjps.galenos.2022.73373","DOIUrl":null,"url":null,"abstract":"Objective: This study aims to develop a microemulsion formula that can increase the solubility and stability of forskolin and is safe for topical use. Materials and Methods: The materials used for the development of the microemulsion formula were triglyceride oil, nonionic surfactants, and polyethylene glycol for cosurfactants which were selected based on the results of the forskolin solubility test using high performance liquid chromatography. Microemulsion was formulated by phase titration method. Formula stability was determined on storage for 90 days at refrigerator, room temperature","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/tjps.galenos.2022.73373","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study aims to develop a microemulsion formula that can increase the solubility and stability of forskolin and is safe for topical use. Materials and Methods: The materials used for the development of the microemulsion formula were triglyceride oil, nonionic surfactants, and polyethylene glycol for cosurfactants which were selected based on the results of the forskolin solubility test using high performance liquid chromatography. Microemulsion was formulated by phase titration method. Formula stability was determined on storage for 90 days at refrigerator, room temperature
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