F. Pakdel, J. Pakdel, Ali Najmeddin, Afshin Peirovi, M. H. Nicknam, F. Dorkoosh
{"title":"A novel controlled release implant of insulin based on Poly (3- hydroxybutyrate-co-3-hydroxyvalerate) polymer prepared by extrusion process","authors":"F. Pakdel, J. Pakdel, Ali Najmeddin, Afshin Peirovi, M. H. Nicknam, F. Dorkoosh","doi":"10.4274/tjps.galenos.2023.10663","DOIUrl":null,"url":null,"abstract":"Introduction Developing and designing an implant with a controlled release of active protein drugs has always been a challenge. In order to optimize and control the release of insulin in this project, the drug complexing mechanism was used by dextran sulfate sodium and PHBV (Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)) polymer. Methods For this purpose","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/tjps.galenos.2023.10663","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction Developing and designing an implant with a controlled release of active protein drugs has always been a challenge. In order to optimize and control the release of insulin in this project, the drug complexing mechanism was used by dextran sulfate sodium and PHBV (Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)) polymer. Methods For this purpose