A novel controlled release implant of insulin based on Poly (3- hydroxybutyrate-co-3-hydroxyvalerate) polymer prepared by extrusion process

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Turkish Journal of Pharmaceutical Sciences Pub Date : 2023-08-28 DOI:10.4274/tjps.galenos.2023.10663
F. Pakdel, J. Pakdel, Ali Najmeddin, Afshin Peirovi, M. H. Nicknam, F. Dorkoosh
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Abstract

Introduction Developing and designing an implant with a controlled release of active protein drugs has always been a challenge. In order to optimize and control the release of insulin in this project, the drug complexing mechanism was used by dextran sulfate sodium and PHBV (Poly (3-hydroxybutyrate-co-3-hydroxyvalerate)) polymer. Methods For this purpose
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基于挤出法制备聚(3-羟基丁酸酯-co-3-羟基戊酸酯)聚合物的新型胰岛素控释植入物
引言开发和设计一种能控制活性蛋白药物释放的植入物一直是一项挑战。为了优化和控制本项目中胰岛素的释放,右旋糖酐硫酸钠和PHBV(聚(3-羟基丁酸酯-co-3-羟基戊酸酯)聚合物采用了药物络合机制。为此目的的方法
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CiteScore
3.60
自引率
5.90%
发文量
79
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