{"title":"Tumor Reduction Potentials of Vernonia Cinerea Sesquiterpenes by Induction of Ferroptosis","authors":"Jimsy Johnson, L. Varghese","doi":"10.1080/10496475.2023.2217491","DOIUrl":null,"url":null,"abstract":"ABSTRACT The anti lymphoma potentials of Vernonia cinerea were evaluated. In a short-term in vitro study, ethyl acetate extract (VCEA) was found to be cytotoxic to DLA cells with an LC50 of 61.24 μg mL−1. GC-MS analysis of VCEA revealed presence of several volatile molecules including nerolidol. Molecular docking study using nerolidol with Ferroportin-1 predicted strong binding affinity, indicating ferroptosis induction which was later confirmed by in vitro assays. VCEA also demonstrated strong reduction in the proliferation of YAC-1, another lymphoma cell line with G2/M arrest leading to apoptosis. The tumor reduction potentials of VCEA was further confirmed using the DLA-induced solid tumor model in mice.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":"29 1","pages":"438 - 451"},"PeriodicalIF":1.2000,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbs, Spices and Medicinal Plants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10496475.2023.2217491","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 1
Abstract
ABSTRACT The anti lymphoma potentials of Vernonia cinerea were evaluated. In a short-term in vitro study, ethyl acetate extract (VCEA) was found to be cytotoxic to DLA cells with an LC50 of 61.24 μg mL−1. GC-MS analysis of VCEA revealed presence of several volatile molecules including nerolidol. Molecular docking study using nerolidol with Ferroportin-1 predicted strong binding affinity, indicating ferroptosis induction which was later confirmed by in vitro assays. VCEA also demonstrated strong reduction in the proliferation of YAC-1, another lymphoma cell line with G2/M arrest leading to apoptosis. The tumor reduction potentials of VCEA was further confirmed using the DLA-induced solid tumor model in mice.
期刊介绍：
The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.
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