{"title":"Translational imaging in toxicology","authors":"Serguei Liachenko","doi":"10.1016/j.cotox.2020.03.006","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>In vivo imaging has a potential to bring innovation to translational toxicology for </span>drug discovery<span><span>. This includes magnetic resonance imaging, positron emission tomography (PET), single photon emission tomography, and </span>computed tomography. The utility of imaging comes from its capacity to provide minimally invasive biomarkers for safety profiling and decision-making in drug discovery. Nonspecific biomarkers, such as magnetic resonance imaging relaxometry, computed tomography density, or PET </span></span><sup>18</sup>F-fluoro-2-deoxy-<span>d</span><span>-glucose are better suited for preclinical general toxicology and clinical monitoring, while specific ones, such as most of PET and single photon emission tomography ligands, are better suited to clarify mechanisms of toxicity or unwanted target engagement. However, the use of these biomarkers is sporadic and governed by scientific interest and availability rather than its utility. A systematic approach is needed to qualify these biomarkers with regulatory authorities so translational imaging could be incorporated into drug development and its unique potential translated into safer and cheaper medicines.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"23 ","pages":"Pages 29-38"},"PeriodicalIF":3.6000,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.03.006","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S246820202030022X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 4
Abstract
In vivo imaging has a potential to bring innovation to translational toxicology for drug discovery. This includes magnetic resonance imaging, positron emission tomography (PET), single photon emission tomography, and computed tomography. The utility of imaging comes from its capacity to provide minimally invasive biomarkers for safety profiling and decision-making in drug discovery. Nonspecific biomarkers, such as magnetic resonance imaging relaxometry, computed tomography density, or PET 18F-fluoro-2-deoxy-d-glucose are better suited for preclinical general toxicology and clinical monitoring, while specific ones, such as most of PET and single photon emission tomography ligands, are better suited to clarify mechanisms of toxicity or unwanted target engagement. However, the use of these biomarkers is sporadic and governed by scientific interest and availability rather than its utility. A systematic approach is needed to qualify these biomarkers with regulatory authorities so translational imaging could be incorporated into drug development and its unique potential translated into safer and cheaper medicines.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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