Cannabis-derived terpenes and flavonoids as potential pharmaceuticals

IF 0.9 4区 生物学 Q4 PLANT SCIENCES Israel Journal of Plant Sciences Pub Date : 2021-01-29 DOI:10.1163/22238980-BJA10022
R. Ofir
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引用次数: 2

Abstract

Terpenes and flavonoids are metabolites produced by many plants, including cannabis plants. Studies suggest that combined treatment based on synergism between plant metabolites has the potential to act better than a single compound. It may be true in the case of cannabis also: the plant content may act better than ‘pure’ cbd. The mode of action of synergism may involve interaction of terpenes/flavonoids with cbd receptors or other receptors; as small metabolites, terpenes/flavonoids may help cannabinoids to cross dermal barrier/to be absorbed orally and/or to cross the blood-brain-barrier. This review summarize studies that discuss the mechanisms of action of terpenes and flavonoids and their effects on various human pathologies. This review cover only part of such studies with the hope to shed light on how synergism between cannabis derived terpenes and flavonoids can improve the action of cannabinoids.
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大麻衍生的萜烯和类黄酮作为潜在的药物
萜烯和类黄酮是许多植物产生的代谢产物,包括大麻植物。研究表明,基于植物代谢物之间协同作用的联合处理有可能比单一化合物发挥更好的作用。大麻也可能是这样:植物含量可能比“纯”cbd更好。协同作用的模式可能涉及萜烯/类黄酮与cbd受体或其他受体的相互作用;作为小的代谢产物,萜烯/类黄酮可能有助于大麻素穿过皮肤屏障/被口服吸收和/或穿过血脑屏障。本文综述了萜烯和黄酮类化合物的作用机制及其对各种人类疾病的影响。这篇综述只涵盖了这类研究的一部分,希望阐明大麻衍生萜烯和类黄酮之间的协同作用如何改善大麻素的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Israel Journal of Plant Sciences
Israel Journal of Plant Sciences 生物-植物科学
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
>12 weeks
期刊介绍: The Israel Journal of Plant Sciences is an international journal of extensive scope that publishes special issues dealing with all aspects of plant sciences, including but not limited to: physiology, cell biology, development, botany, genetic
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