{"title":"Use of Doubling Number as an Arithmetic Measure of Plant Cell Growth and Metal-Induced Cell Growth Inhibition","authors":"M. Metin, T. Kawano","doi":"10.35378/gujs.1244209","DOIUrl":null,"url":null,"abstract":"Cell growth inhibition is generally handled as a measure of toxicity. Shortly, more toxicity implies more growth inhibition. Then, the question arises; How to calculate & evaluate cell growth inhibition in a universal manner? Actually, the method for calculating growth inhibition is not considered to be a central issue, in general. There are various approaches for calculating cell growth. Among these approaches, two of them are highly easy and popular, subtraction-based and division-based calculations. However, these two methods for the calculation of cell growth do not strongly reflect the nature of cell growth. Alternatively, the use of a doubling number-based formulation can provide a better approach and performance in the evaluation of cell growth and cell growth inhibition unless the culture attains the confluent status. Here, we discussed different methods of growth calculation which we applied to the study of “growth inhibition of BY-2 cells under Cd exposure”.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"gazi university journal of science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35378/gujs.1244209","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Cell growth inhibition is generally handled as a measure of toxicity. Shortly, more toxicity implies more growth inhibition. Then, the question arises; How to calculate & evaluate cell growth inhibition in a universal manner? Actually, the method for calculating growth inhibition is not considered to be a central issue, in general. There are various approaches for calculating cell growth. Among these approaches, two of them are highly easy and popular, subtraction-based and division-based calculations. However, these two methods for the calculation of cell growth do not strongly reflect the nature of cell growth. Alternatively, the use of a doubling number-based formulation can provide a better approach and performance in the evaluation of cell growth and cell growth inhibition unless the culture attains the confluent status. Here, we discussed different methods of growth calculation which we applied to the study of “growth inhibition of BY-2 cells under Cd exposure”.
期刊介绍:
The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.