The validated method for the analysis of a mixture of psychotropic medicines olanzapine, clorazepate and escitalopram using a high-performance liquid chromatography method

IF 0.5 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Chemija Pub Date : 2022-05-04 DOI:10.6001/chemija.v33i2.4706

Mamdouh Alasabashi, A. Ževžikovienė, M. Marksa, Laura Rimkiene, A. Ževžikovas

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Abstract

It was established that self-poisoning with antipsychotics, anti-anxiety drugs and antidepressants is caused by consumption of the drug in higher doses than prescribed. So it is very important to determine fast the materials causing poisoning and use the method which would allow one to identify several substances during only one analysis. Reference and test solutions were prepared in ethanol. A qualitative and quantitative analysis was carried out on a Waters Alliance 2695 liquid chromatograph equipped with a Waters 996 PDA detector and an ACE C18 (250 mm × 4.6 mm × 5 μm) column. The mobile phase consisted of solvent trifluoroacetic acid (0.1 %) and acetonitrile. The linear gradient elution profile was used. For the validation process the following parameters were chosen: specificity, repeatability, precision and limits (LOD and LOQ). According to the study results, it can be concluded that the validated method for the qualitative and quantitative evaluation analysis of olanzapine, clorazepate and escitalopram was developed.

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建立了一种高效液相色谱法分析精神药物奥氮平、氯硝西酯和艾司西酞普兰混合物的方法

已经确定的是，服用抗精神病药物、抗焦虑药物和抗抑郁药物的自我中毒是由于服用剂量高于处方剂量造成的。因此，快速确定引起中毒的物质和使用在一次分析中可以识别多种物质的方法是非常重要的。在乙醇中制备参比液和被试液。采用Waters Alliance 2695型液相色谱仪，配备Waters 996 PDA检测器和ACE C18 (250 mm × 4.6 mm × 5 μm)色谱柱进行定性和定量分析。流动相为溶剂三氟乙酸(0.1%)和乙腈。采用线性梯度洗脱剖面。对于验证过程，选择以下参数:特异性、重复性、精密度和限(LOD和LOQ)。根据研究结果，建立了奥氮平、氯硝西酯和艾司西酞普兰的定性和定量评价分析方法。

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来源期刊

Chemija 化学-化学综合

CiteScore

1.30

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： Chemija publishes original research articles and reviews from all branches of modern chemistry, including physical, inorganic, analytical, organic, polymer chemistry, electrochemistry, and multidisciplinary approaches.