Effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on liver function indices of benign prostatic hyperplasia (BPH) induced rats

Abstract

Abstract Objective This study evaluated the effects of combined ethanol extract of Funtumia africana and Abutilon mauritianum leaves (FAAM) on the liver function indices of benign prostatic hyperplasia (BPH) induced rats. Materials and Methods The study used 30 rats divided into 5 groups, comprising normal control, BPH control, standard control, and BPH induced rats treated with 200 and 600 mg/kg/day of FAAM respectively. Results The BPH induction caused significant (p<0.05) increases in aspartate transaminase (AST) and alkaline phosphatase (ALP) activities of the BPH control when compared with the normal control. The BPH control also had significantly (p<0.05) reductions in the total protein, albumin and globulin concentrations and significant (p<0.05) elevated total bilirubin and direct bilirubin concentrations relative to the normal control. The FAAM treated BPH-induced rats had non-significantly (p>0.05) reduced AST, and alanine transaminase (ALT) activities relative to the BPH control. The BPH-induced rats treated with 600 mg/kg/day of FAAM had significantly (p<0.05) reduced ALP activities relative to the BPH control. Treatment with FAAM caused significant (p<0.05) increases in the total protein, albumin, globulin concentrations and significant (p<0.05) reductions in the total bilirubin and direct bilirubin concentrations relative to the BPH control. BPH had no observable adverse effects on the liver histomorphology of the rats. Conclusion The findings of this study indicated that BPH impairs liver functions and treatment of BPH with combined ethanol extract of F. africana and A. mauritianum leaves restore normal liver functions in rats with BPH.