Analysis of the effect of valproic acid with different loading doses in treatment of children with status epilepticus

Qiaolin Chen, Chen-mei Zhang
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Abstract

Objective To explore the effect of valproic acid with different loading doses in treatment of children with status epilepticus. Methods The data of children who were hospitalized in the intensive care unit of the Children′s Hospital Affiliated to Zhejiang University because of status epilepticus from January 1, 2013 to December 31, 2017 were collected.All the patients were divided into different groups according to loading dose of valproic acid.The effect were analyzed in different groups. Results (1)There were 66 children with status epilepticus were admitted, including 35 males and 31 females.Among all children with status epilepticus, the etiology included epilepsy(n=36, 54.5%), intracranial infection(n=16, 24.2%), hypoxic asphyxia (n=3, 4.5%), intracranial tumor(n=2, 3.0%), abnormal brain development(n=2, 3.0%), intracranial hemorrhage(n=2, 3.0%), and etiology was not clear(n=5, 7.6%). (2)All children with status epilepticus were divided into four groups according to different valproic acid loading dose(0 mg/kg, 10-15 mg/kg, 16-39 mg/kg, 40 mg/kg). There are no significant differences in gender and age among groups.There were no significant differences in duration of status epilepticus and epileptic treatment efficiency(P=0.402, 0.034). (3)All children were monitored for liver function after the treatment of sodium valproate, and no patient had been found increased alanine aminotransferase. Conclusion There are no significant differences in the effect of different valproic acid loading doses in children with status epilepticus, and no adverse side effects are observed in children with status epilepticus who received a dose of 40 mg/kg. Key words: Status epilepticus; Valproic acid; Loading dose
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不同负荷剂量丙戊酸治疗儿童癫痫持续状态的疗效分析
目的探讨不同负荷剂量丙戊酸治疗儿童癫痫持续状态的疗效。方法收集2013年1月1日至2017年12月31日因癫痫持续状态在浙江大学附属儿童医院重症监护室住院的儿童资料。根据丙戊酸负荷剂量将所有患者分为不同的组。对不同组的疗效进行分析。结果(1)共收治癫痫持续状态患儿66例,其中男35例,女31例。在所有癫痫持续状态的儿童中,病因包括癫痫(n=3654.5%)、颅内感染(n=1624.2%)、缺氧性窒息(n=3,4.5%)、颅内肿瘤(n=2/3.0%)、大脑发育异常(n=2/3.0%)、颅内出血(n=2-3.0%),(2)将癫痫持续状态患儿按丙戊酸负荷剂量(0 mg/kg、10~15 mg/kg、16~39 mg/kg、40 mg/kg)分为4组。各组之间在性别和年龄方面没有显著差异。癫痫持续时间和癫痫治疗效率无显著差异(P=0.402,0.034)。(3)所有儿童在接受丙戊酸钠治疗后均进行了肝功能监测,未发现患者丙氨酸氨基转移酶升高。结论不同丙戊酸负荷剂量对癫痫持续状态患儿的疗效无显著差异,40mg/kg剂量的癫痫持续状态儿童无不良反应。关键词:癫痫持续状态;丙戊酸;加载剂量
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期刊介绍: Chinese Journal of Neurology was established in 1955, the predecessor of which is Chinese Journal of Neurology and Psychiatry. Chinese Journal of Neurology and Psychiatry has been indexed by MEDLINE until 1996, when it was divided into two journals, Chinese Journal of Neurology, and Chinese Journal of Psychiatry. Chinese Journal of Neurology is now indexed by EM, SCOPUS, AJ, WPRIM, CNKI, Wanfang Data, CSCD, etc. The impact factor of the journal is 2.755 in 2017, ranking the first among all neurological and psychological journals in China and among all the 142 medical journals published by the Chinese Medical Association. The journal is available both in print and online.
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