Follicular renewal and stemness potency of follicular cells depended of telomerase activity and TERT expression – short review

Q4 Biochemistry, Genetics and Molecular Biology Medical Journal of Cell Biology Pub Date : 2022-03-01 DOI:10.2478/acb-2022-0005

D. Bukowska M. Grzesiak R. Procházka P. Mozdziak M. Skowroński W. Kranc P. Antosik A. G. Narenji Wiktoria Zgórecka Kornelia Krajnik

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Abstract

Abstract Several hypotheses have been proposed, relating to the potential genesis of follicular cells in the ovarian niche. Reports using mice as an experimental model have suggested that the ovaries may contain stem cells that are likely involved in the formation of new follicles in adult reproductive life. Over recent years, various types of ovarian cells have been identified and described to confirm or disprove the existence of ovarian adult stem cells. Most research is focused on granulosa cells (GCs), which are essential for follicular development and maturation of female germ cells (oocytes). GCs exhibit the features of stem cells, such as expression of stem cell markers: OCT-4, Sox-2, Nanog as well as certain markers of mesenchymal stem cells, including CD29, CD44, CD90, CD105, CD117, and CD166. Another discovery in favor of the potential stemness of GCs is their ability to transdifferentiate towards other cell lines and high telomerase (TERT) activity in dividing compartments of the follicle during its maturation.

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端粒酶活性和TERT表达对卵泡细胞再生和干性的影响

摘要:关于卵巢生态位中卵泡细胞的潜在发生，已经提出了几个假设。使用小鼠作为实验模型的报告表明，卵巢可能含有干细胞，这些干细胞可能参与成年生殖生活中新卵泡的形成。近年来，各种类型的卵巢细胞被鉴定和描述，以证实或反驳卵巢成体干细胞的存在。大多数研究都集中在颗粒细胞(GCs)上，它们是女性生殖细胞(卵母细胞)卵泡发育和成熟所必需的。GCs具有干细胞的特征，如表达干细胞标记物OCT-4、Sox-2、Nanog以及某些间充质干细胞标记物CD29、CD44、CD90、CD105、CD117和CD166。支持GCs潜在干性的另一项发现是它们向其他细胞系转分化的能力，以及在卵泡成熟过程中卵泡分裂室的高端粒酶(TERT)活性。

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Medical Journal of Cell Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

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