Novel pyrrolo[2,3-b]pyridine and pyrrolo[2,3-d] pyrimidine derivatives: Design, synthesis, and structure elucidation

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-05-12 DOI:10.4314/bcse.v37i4.14

Khaled M.H. Hilmy, Fawzya N.M. Kishk, Esmat B.A. Shahen, Mohamed A. Hawata

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Abstract

ABSTRACT. A cyclo condensation reaction is an effective method for a two-component reaction of 2-amino-1,5-diphenyl-1H-pyrrole-3-carbonitrile 3a-c and active methylene compounds in acetic acid and catalytic hydrochloric acid to produce new substituted 1H-pyrrolo[2,3-b]pyridine 4a-c, 5a-c, and 6a-c have been established. Additionally, a new series of substituted 1H-pyrrolo[2,3-d]pyrimidines 7a-c and 8a-c could be synthesized utilizing a feasible and efficient approach, including urea and thiourea substrates. Spectroscopic data IR, MS, 1H, and 13C NMR, as well as elemental analyses, elucidated these compounds' structures. KEY WORDS: 1H-Pyrrolo[2,3-b]pyridine, 1H-Pyrrolo[2,3-d]pyrimidines, Active methylene compounds Bull. Chem. Soc. Ethiop. 2023, 37(4), 983-992. DOI: https://dx.doi.org/10.4314/bcse.v37i4.14

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新型吡咯并[2,3-b]吡啶和吡咯并[2-3-d]嘧啶衍生物的设计、合成和结构鉴定

摘要。环缩合反应是2-氨基-1,5-二苯基-1H-吡咯-3-腈3a-c与活性亚甲基化合物在乙酸和催化盐酸中双组分反应生成新的取代的1H-吡咯并[2,3-b]吡啶的有效方法。此外，利用一种可行而有效的方法，包括尿素和硫脲底物，可以合成一系列新的取代的1H-吡咯并[2,3-d]嘧啶7a-c和8a-c。光谱数据IR、MS、1H和13C NMR以及元素分析阐明了这些化合物的结构。关键词：1H-吡咯并[2,3-b]吡啶，1H-吡咯[2,3-d]嘧啶，活性亚甲基化合物Bull。化学。Soc.Ethiop。2023，37（4），983-992.DOI:https://dx.doi.org/10.4314/bcse.v37i4.14

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.