A retrospective study of the clinical characteristics of COVID-19 patients with gastrointestinal symptoms

A. Zhang, Yi Zhang, Y. Leng, Yifan Jia, S. Lei, Z. Xia
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Abstract

Objective: To investigate the gastrointestinal (GI) manifestations of COVID-19 and retrospectively analyze the clinical characteristics of COVID-19 patients with GI symptoms. Methods: Data of 137 COVID-19 inpatients treated in Renmin Hospital of Wuhan University from February 1 to February 29, 2020 were collected. Patients were divided into GI group and Non-GI group according to the presence of digestive system abnormalities and gastrointestinal symptoms before and during admission. General data, clinical data, and relevant laboratory examination results of 137 patients were collected. SPSS 23.0 software was used for statistical analysis to compare the differences of various indicators between the two groups. Results: There was no statistically significant difference between the clinical data and the clinical manifestations of fever and dry cough between the GI group and the Non-GI group (P>0.05). The proportion of patients with fatigue in the GI group was higher than that in the Non-GI group (P 0.05). The proportion of monocytes in the GI group was lower than that in the Non-GI group (P=0.033). There was no statistical difference in platelet count and C-reactive protein level between the two groups (P>0.05). LDH, TBIL, and Urea levels of GI group were higher than those of Non-GI group (P 0.05), but D-dimer in GI group was higher than in Non-GI group (P<0.001). Conclusion: Gastrointestinal symptoms are common in COVID-19 patients, and patients with other underlying diseases are at greater risk for developing gastrointestinal symptoms. COVID-19 patients with gastrointestinal symptoms progress more rapidly, have a higher mortality rate, and exhibit certain concomitant symptoms and laboratory tests that are specific to COVID-19. Therefore, more attention should be paid to the digestive system abnormalities and gastrointestinal symptoms in COVID-19 patients during clinical work. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.
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新冠肺炎胃肠道症状患者临床特征的回顾性研究
目的:探讨新型冠状病毒肺炎(COVID-19)的胃肠道(GI)表现,回顾性分析新型冠状病毒肺炎(COVID-19)患者胃肠道症状的临床特点。方法:收集2020年2月1日至2月29日武汉大学人民医院收治的137例新冠肺炎住院患者资料。根据患者入院前及入院中有无消化系统异常及胃肠道症状分为GI组和非GI组。收集137例患者的一般资料、临床资料及相关实验室检查结果。采用SPSS 23.0软件进行统计分析,比较两组间各项指标的差异。结果:GI组与非GI组的临床资料及发热、干咳等临床表现比较,差异均无统计学意义(P < 0.05)。GI组出现疲劳的患者比例高于非GI组(P < 0.05)。GI组单核细胞比例低于非GI组(P=0.033)。两组患者血小板计数、c反应蛋白水平比较,差异无统计学意义(P < 0.05)。GI组LDH、TBIL、尿素水平高于非GI组(P< 0.05), d -二聚体水平高于非GI组(P<0.001)。结论:胃肠道症状在新冠肺炎患者中较为常见,其他基础疾病患者出现胃肠道症状的风险较大。伴有胃肠道症状的COVID-19患者进展更快,死亡率更高,并伴有某些COVID-19特有的伴随症状和实验室检查。因此,在临床工作中应更加重视COVID-19患者的消化系统异常和胃肠道症状。©2021,武汉大学医学杂志编辑委员会。版权所有。
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来源期刊
武汉大学学报(医学版)
武汉大学学报(医学版) Medicine-Medicine (all)
CiteScore
0.30
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0.00%
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7289
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