{"title":"MR spectroscopy in Alzheimer’s disease","authors":"N. Sheikh-Bahaei","doi":"10.3233/bsi-200194","DOIUrl":null,"url":null,"abstract":"MR Spectroscopy (MRS) has been used for diagnosis of many neurological disorders such as central nervous system tumors and neuro-inflammatory diseases. Despite many studies on MRS in neurodegenerative disorders and particularly Alzheimer’s disease, its utility has been hampered by lack of standard techniques across studies and limited data on the association between the level of metabolites in MRS and pathological changes of AD. In this review we have summarized the findings of MRS in Alzheimer’s disease, discussed the limitation of the current data and the pitfalls in interpretation of the MRS results and also we presented the latest developments in this field and potential future steps in order to utilize MRS more effectively in clinical practice.","PeriodicalId":44239,"journal":{"name":"Biomedical Spectroscopy and Imaging","volume":" ","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/bsi-200194","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Spectroscopy and Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/bsi-200194","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
引用次数: 5
Abstract
MR Spectroscopy (MRS) has been used for diagnosis of many neurological disorders such as central nervous system tumors and neuro-inflammatory diseases. Despite many studies on MRS in neurodegenerative disorders and particularly Alzheimer’s disease, its utility has been hampered by lack of standard techniques across studies and limited data on the association between the level of metabolites in MRS and pathological changes of AD. In this review we have summarized the findings of MRS in Alzheimer’s disease, discussed the limitation of the current data and the pitfalls in interpretation of the MRS results and also we presented the latest developments in this field and potential future steps in order to utilize MRS more effectively in clinical practice.
期刊介绍：
Biomedical Spectroscopy and Imaging (BSI) is a multidisciplinary journal devoted to the timely publication of basic and applied research that uses spectroscopic and imaging techniques in different areas of life science including biology, biochemistry, biotechnology, bionanotechnology, environmental science, food science, pharmaceutical science, physiology and medicine. Scientists are encouraged to submit their work for publication in the form of original articles, brief communications, rapid communications, reviews and mini-reviews. Techniques covered include, but are not limited, to the following: • Vibrational Spectroscopy (Infrared, Raman, Teraherz) • Circular Dichroism Spectroscopy • Magnetic Resonance Spectroscopy (NMR, ESR) • UV-vis Spectroscopy • Mössbauer Spectroscopy • X-ray Spectroscopy (Absorption, Emission, Photoelectron, Fluorescence) • Neutron Spectroscopy • Mass Spectroscopy • Fluorescence Spectroscopy • X-ray and Neutron Scattering • Differential Scanning Calorimetry • Atomic Force Microscopy • Surface Plasmon Resonance • Magnetic Resonance Imaging • X-ray Imaging • Electron Imaging • Neutron Imaging • Raman Imaging • Infrared Imaging • Terahertz Imaging • Fluorescence Imaging • Near-infrared spectroscopy.
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