IS PREDICTION OF RENAL FAILURE WITH ITS INDICES FEASIBLE WITH PRESENCE OF HISTOPATHOLOGIC EVIDENCE FOR GASTRIC INTESTINAL METAPLASIA ?

Abstract

Objectives: Gastric intestinal metaplasia have traditionally been associated with gastric adenocarcinoma. Gastric intestinal metaplasia is usually related to the Helicobacter pylori infection, older ages, smoking history, consumption of strong spicy foods, socioeconomic status and presence of IL10-592 C/A. The purpose of the present research study was to evaluate the simple laboratory parameters in subjects with gastric intestinal metaplasia Findings: From May 2018 and October 2018, a total of 541, 281 male and 260 female, consecutive cases with gastric intestinal metaplasia with the mean age of 58.5±15 years had been enrolled retrospectively with exclusion of the cases with a severe underlying disease, including a gastric cancer and gastric resection. The gastroscopy with the antral biopsy had been performed for all the cases and the biopsy samples had been evaluated for the presence of gastric intestinal metaplasia by Hematoxylin and Eosin and Helicobacter pylori status by Giemsa.The chi-squared test and independent t test were used for comparison. The mean serum urea level detected as 34.2.±16.1 mg/dL in the gastric intestinal metaplasia and 31.2±13.1 mg/dL in the control (95% CI from 32,3 to 34,6; p =0.013), while the mean serum creatinin level 0.84±0.28 mg/dL in the gastric intestinal metaplasia and 0.80±0.26 mg/dL in the control (95% CI from 0,80 to 0,85; p =0.042).  Gastric intestinal metaplasia was detected mostly in elderly and male, regarding the multiple logistic regression ( p <0.001). Conclusion: The serum urea and creatinin levels may serve as a simple clinical tool to predict the cases patients at risk for gastric intestinal metaplasia.