Introduction: Neuroinflammation plays a key role in various neurological conditions, including migraine. GON block has been used for both acute and preventive treatment in migraine sufferers. Exploring whether this localized nerve blocking therapy for migraines affects signs of systemic inflammation would be beneficial. Materials and Methods: In this study, a total of 50 migraineurs (comprising high-frequency episodic and chronic migraine) and 60 healthy control volunteers of comparable ages and sexes were enrolled. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII levels in migraine patients, migraine sufferers, and healthy individuals are compared. This study examined hematological parameters and SII levels used as inflammatory markers in those diagnosed with migraine. Results: It was determined that the mean platelet and PLR values of the case group's subjects were substantially lower than those of the patient group's subjects (p < 0.05). Biochemical characteristics of the cases were examined before and after treatment with greater occipital nerve (GON) block, revealing a statistically significant reduction in attack frequency, severity, and duration (p < 0.001). No significant differences were discovered when compared to post-treatment values (p > 0.05), even though the ratios were greater prior to GON block therapy in other measures. Conclusion: These findings, in our opinion, are linked to the presence of a continuous inflammatory process even in the absence of episodes, supporting systemic inflammation in migraineurs. Thus, SII, an affordable and easily measurable marker in peripheral blood, may serve as a helpful predictive marker for migraine patients scheduled for GON block treatment. Further extensive research is needed to determine whether SII can be an independent prognostic factor in migraine patients.
{"title":"The value of the systemic immune inflammation index (SII) in migraine patients treated with greater occipital block treatment","authors":"Sevil Sadri, Gözde Ülfer, Burcu Polat","doi":"10.5937/sanamed0-44601","DOIUrl":"https://doi.org/10.5937/sanamed0-44601","url":null,"abstract":"Introduction: Neuroinflammation plays a key role in various neurological conditions, including migraine. GON block has been used for both acute and preventive treatment in migraine sufferers. Exploring whether this localized nerve blocking therapy for migraines affects signs of systemic inflammation would be beneficial. Materials and Methods: In this study, a total of 50 migraineurs (comprising high-frequency episodic and chronic migraine) and 60 healthy control volunteers of comparable ages and sexes were enrolled. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII levels in migraine patients, migraine sufferers, and healthy individuals are compared. This study examined hematological parameters and SII levels used as inflammatory markers in those diagnosed with migraine. Results: It was determined that the mean platelet and PLR values of the case group's subjects were substantially lower than those of the patient group's subjects (p < 0.05). Biochemical characteristics of the cases were examined before and after treatment with greater occipital nerve (GON) block, revealing a statistically significant reduction in attack frequency, severity, and duration (p < 0.001). No significant differences were discovered when compared to post-treatment values (p > 0.05), even though the ratios were greater prior to GON block therapy in other measures. Conclusion: These findings, in our opinion, are linked to the presence of a continuous inflammatory process even in the absence of episodes, supporting systemic inflammation in migraineurs. Thus, SII, an affordable and easily measurable marker in peripheral blood, may serve as a helpful predictive marker for migraine patients scheduled for GON block treatment. Further extensive research is needed to determine whether SII can be an independent prognostic factor in migraine patients.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: This retrospective clinical study aimed to investigate patient profiles and wound degree changes, as well as cultural details, resulting from delayed admissions to burn centers following burn trauma. Methods: Patients were categorized into five groups based on the time of hospital admission after the burn trauma: 0 days, 1 st day, 2 nd day, 3 rd day, and 4 th day and beyond. Results: During the study period, 1092 patients were admitted to the hospital on the day of their burn trauma. A total of 324 (22.8%) patients-131 (40.4%) women and 193 (59.6%) men-were admitted to the hospital 1 day or more after the trauma. These patients were admitted to the hospital 3.77 (min = 1, max = 27) days after receiving the burn, on average. Of the 324 patients admitted to the hospital after 1 day, 57.9% were rural residents, and 42.1% were urban residents. The most common cause of wound site infection was Staphylococcus aureus, with 20.18%. No statistically significant difference existed between the number of days of delayed hospital admission and the duration of hospitalization. Conclusion: Delays in hospital admission significantly influence changes in burn wound conditions.
{"title":"Wound changes following delayed admission to the burn center","authors":"Ebral Yiğit, Demir Yiğit","doi":"10.5937/sanamed0-45459","DOIUrl":"https://doi.org/10.5937/sanamed0-45459","url":null,"abstract":"Introduction: This retrospective clinical study aimed to investigate patient profiles and wound degree changes, as well as cultural details, resulting from delayed admissions to burn centers following burn trauma. Methods: Patients were categorized into five groups based on the time of hospital admission after the burn trauma: 0 days, 1 st day, 2 nd day, 3 rd day, and 4 th day and beyond. Results: During the study period, 1092 patients were admitted to the hospital on the day of their burn trauma. A total of 324 (22.8%) patients-131 (40.4%) women and 193 (59.6%) men-were admitted to the hospital 1 day or more after the trauma. These patients were admitted to the hospital 3.77 (min = 1, max = 27) days after receiving the burn, on average. Of the 324 patients admitted to the hospital after 1 day, 57.9% were rural residents, and 42.1% were urban residents. The most common cause of wound site infection was Staphylococcus aureus, with 20.18%. No statistically significant difference existed between the number of days of delayed hospital admission and the duration of hospitalization. Conclusion: Delays in hospital admission significantly influence changes in burn wound conditions.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Drug-eluting stents (DES) have higher marked efficacy and lower revascularization requirements compared to bare metal stents (BMS).We aimed to determine the mid-term outcomes of patients implanted with a first-generation DES "paclitaxel-eluting stents" (PES). Methods: Patients with at least 1 PES implanted in our cardiology clinic were received in the nonrandomized group. Inclusion criteria were all patients undergoing percutaneous coronary intervention and PES implantation. The mean follow-up time was 35.14 + 13.4 months. Results: A total of 302 patients (401 lesions and 337 PES) were enrolled in the study. The mean age was 61.86 + 10.27 years. Major adverse cardiac and cerebrovascular events (MACE) occurred at 17.9%, and the stent thrombosis rate was 4%. Independent predictors of stent thrombosis were serum creatinine levels [OR 1.59; 95% CI, 1.03-2.46, p=0.03] and mean platelet volume [OR 1.59; 95% CI, 1.03-2.46, p= 0.03]. Also, poor functional capacity [OR 2.46: 95% CI, 1.42-4.26, p<0.001] and positive ischemia test [OR 3.43: 95% CI, (1.73-6.82), p<0.001] were predictors of MACE's. Conclusions: We have demonstrated that PES is safe and effective in the mid-term for use in coronary artery disease.
{"title":"The effects of clinical, laboratory, and angiographic factors on stent thrombosis and major adverse cardiac events in paclitaxel eluting stents","authors":"Çağlayan Kandemir, Zafer Baytugan","doi":"10.5937/sanamed0-43499","DOIUrl":"https://doi.org/10.5937/sanamed0-43499","url":null,"abstract":"Background: Drug-eluting stents (DES) have higher marked efficacy and lower revascularization requirements compared to bare metal stents (BMS).We aimed to determine the mid-term outcomes of patients implanted with a first-generation DES \"paclitaxel-eluting stents\" (PES). Methods: Patients with at least 1 PES implanted in our cardiology clinic were received in the nonrandomized group. Inclusion criteria were all patients undergoing percutaneous coronary intervention and PES implantation. The mean follow-up time was 35.14 + 13.4 months. Results: A total of 302 patients (401 lesions and 337 PES) were enrolled in the study. The mean age was 61.86 + 10.27 years. Major adverse cardiac and cerebrovascular events (MACE) occurred at 17.9%, and the stent thrombosis rate was 4%. Independent predictors of stent thrombosis were serum creatinine levels [OR 1.59; 95% CI, 1.03-2.46, p=0.03] and mean platelet volume [OR 1.59; 95% CI, 1.03-2.46, p= 0.03]. Also, poor functional capacity [OR 2.46: 95% CI, 1.42-4.26, p<0.001] and positive ischemia test [OR 3.43: 95% CI, (1.73-6.82), p<0.001] were predictors of MACE's. Conclusions: We have demonstrated that PES is safe and effective in the mid-term for use in coronary artery disease.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71047238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medical waste is all waste generated by healthcare institutions related to the performance of medical-technical actions in the field of diagnostics, therapy, or research activities. The adequate disposal of medical waste is an issue for virtually all Southeastern European countries primarily because these countries lack the necessary capacities for removing medical waste. The paper aims to review the results and experiences of treating medical waste, as well as the potential risks to patients and medical and non-medical personnel. Implementing a safe medical waste management system could significantly improve the quality of healthcare services and the health of patients, and preserve the environment. The use of steam sterilization has been suggested to reduce the content of biological agents in the waste to an acceptable level by thermal treatment, that is, to achieve biological inactivation.
{"title":"Improvement of medical waste storage procedures","authors":"Branislav Sančanin, Aleksandra Sančanin","doi":"10.5937/sanamed0-42519","DOIUrl":"https://doi.org/10.5937/sanamed0-42519","url":null,"abstract":"Medical waste is all waste generated by healthcare institutions related to the performance of medical-technical actions in the field of diagnostics, therapy, or research activities. The adequate disposal of medical waste is an issue for virtually all Southeastern European countries primarily because these countries lack the necessary capacities for removing medical waste. The paper aims to review the results and experiences of treating medical waste, as well as the potential risks to patients and medical and non-medical personnel. Implementing a safe medical waste management system could significantly improve the quality of healthcare services and the health of patients, and preserve the environment. The use of steam sterilization has been suggested to reduce the content of biological agents in the waste to an acceptable level by thermal treatment, that is, to achieve biological inactivation.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71047179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breastfeeding is the best way to feed a child from the first six months until the end of the second year. The unbreakable bond during pregnancy between a mother and her child continues during the lactation process, providing numerous benefits for both the mother and the child. Due to the effects of many hormones after childbirth, lactation offers numerous advantages for the mother. Oxytocin causes reduction of the uterus and bleeding, absence of menstruation, faster return of body weight, lower risk of cancer of the reproductive organs, and prevents the occurrence of osteoporosis and the development of the metabolic syndrome. Breastfeeding certainly ensures a better emotional bond with the child. Specificity in the composition of human milk provides the newborn with short-term and long-term protective effects. Thanks to human oligosaccharides, immunoglobulins, and polyunsaturated fatty acids that influence the composition of the microbiome of the newborn's intestine, as well as the formation of its immune response, breastfed children suffer less from respiratory and digestive infections, food allergies, autoimmune diseases and have been proven to have a higher IQ. Breastfeeding is the best form of feeding for mother and child. The specificity of the composition of human milk ensures optimal growth and development of the child and a healthier life for its mother.
{"title":"Benefits of breastfeedinig for mother and child","authors":"Jelena Miolski","doi":"10.5937/sanamed0-41390","DOIUrl":"https://doi.org/10.5937/sanamed0-41390","url":null,"abstract":"Breastfeeding is the best way to feed a child from the first six months until the end of the second year. The unbreakable bond during pregnancy between a mother and her child continues during the lactation process, providing numerous benefits for both the mother and the child. Due to the effects of many hormones after childbirth, lactation offers numerous advantages for the mother. Oxytocin causes reduction of the uterus and bleeding, absence of menstruation, faster return of body weight, lower risk of cancer of the reproductive organs, and prevents the occurrence of osteoporosis and the development of the metabolic syndrome. Breastfeeding certainly ensures a better emotional bond with the child. Specificity in the composition of human milk provides the newborn with short-term and long-term protective effects. Thanks to human oligosaccharides, immunoglobulins, and polyunsaturated fatty acids that influence the composition of the microbiome of the newborn's intestine, as well as the formation of its immune response, breastfed children suffer less from respiratory and digestive infections, food allergies, autoimmune diseases and have been proven to have a higher IQ. Breastfeeding is the best form of feeding for mother and child. The specificity of the composition of human milk ensures optimal growth and development of the child and a healthier life for its mother.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71047097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yılmaz, Zahide Koşan, Yerli Bilge, Tanriverdi Çınar, Yılmaz İba
Introduction: Burnout, characterized by emotional exhaustion, depersonalization, and low personal accomplishment, is frequently observed in physicians. Aim: The purpose of this study was to determine burnout levels and associated factors in physicians during the pandemic. Material and Method: This cross-sectional study was performed online with 288 physicians from various fields in Erzurum. Sociodemographic questions and the Maslach Burnout Inventory represented the data collection tools. The data were collected online in May and June 2021. Statistical analysis: Descriptive statistics, Student's t and ANOVA tests And Multiple ordinal logistic regression analysis were used. p values <0.05 were regarded as significant. Analysis was performed on SPSS 22. Results: Physicians' mean emotional exhaustion, depersonalization, and personal accomplishment component scores were 20.1±8.3, 6.7±4.5, and 21.1±4.5, respectively. Analysis showed that 49.7% of physicians exhibited moderate-high emotional exhaustion, 35.8% high-moderate depersonalization, and 69.8% signs of low personal accomplishment. Job title, regret concerning selecting the medical profession, satisfaction with the working environment, number of additional monthly out-of-hours shifts worked, regular sporting activity, and assessment of the physical conditions in the working environment emerged as factors affecting burnout components at regression analysis. Conclusion: The participants' burnout levels were high. The planning of effective interventions addressing individual and work-related factors with a holistic approach is essential to halt this rapidly growing epidemic.
{"title":"Physician burnout levels and associated factors in The Covid-19 pandemic","authors":"S. Yılmaz, Zahide Koşan, Yerli Bilge, Tanriverdi Çınar, Yılmaz İba","doi":"10.5937/sanamed0-41562","DOIUrl":"https://doi.org/10.5937/sanamed0-41562","url":null,"abstract":"Introduction: Burnout, characterized by emotional exhaustion, depersonalization, and low personal accomplishment, is frequently observed in physicians. Aim: The purpose of this study was to determine burnout levels and associated factors in physicians during the pandemic. Material and Method: This cross-sectional study was performed online with 288 physicians from various fields in Erzurum. Sociodemographic questions and the Maslach Burnout Inventory represented the data collection tools. The data were collected online in May and June 2021. Statistical analysis: Descriptive statistics, Student's t and ANOVA tests And Multiple ordinal logistic regression analysis were used. p values <0.05 were regarded as significant. Analysis was performed on SPSS 22. Results: Physicians' mean emotional exhaustion, depersonalization, and personal accomplishment component scores were 20.1±8.3, 6.7±4.5, and 21.1±4.5, respectively. Analysis showed that 49.7% of physicians exhibited moderate-high emotional exhaustion, 35.8% high-moderate depersonalization, and 69.8% signs of low personal accomplishment. Job title, regret concerning selecting the medical profession, satisfaction with the working environment, number of additional monthly out-of-hours shifts worked, regular sporting activity, and assessment of the physical conditions in the working environment emerged as factors affecting burnout components at regression analysis. Conclusion: The participants' burnout levels were high. The planning of effective interventions addressing individual and work-related factors with a holistic approach is essential to halt this rapidly growing epidemic.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71047157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enes Zogić, Kemal Alihodzic, Demir Tokovic, Aldin Nicevic
Necrotizing soft tissue infections (NSTIs) are serious and potentially fatal rapidly progressive and aggressive infections of subcutaneous tissue, fascia
{"title":"Necrotizing soft tissue infections: An unpredictible, life-threatening infections","authors":"Enes Zogić, Kemal Alihodzic, Demir Tokovic, Aldin Nicevic","doi":"10.5937/sanamed0-45959","DOIUrl":"https://doi.org/10.5937/sanamed0-45959","url":null,"abstract":"Necrotizing soft tissue infections (NSTIs) are serious and potentially fatal rapidly progressive and aggressive infections of subcutaneous tissue, fascia","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Özlem Terzi, Esra Arslantaş, Nur Baş, Ayşe Kaçar, Pasli Uysalol, Avni Solgun, Duygu Yıldırgan, Özkan Karagenç, Ertürk Saide, Ali Ayçiçek
Objective: Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Propranolol (P), a nonselective beta-blocker, has been successfully used in managing IHs. Ongoing studies investigate the efficacy of the topical b-antagonist timolol maleate (TM) in IHs. The aim of this study is to assess the effects of interventions for managing infantile hemangiomas in children. Material and Methods: We retrospectively reviewed a total of 403 IH patients from March 2021 to March 2022. The patients were stratified into three groups. Patients in Group 1 were given TM at a dose of one drop topically twice a day, 0.5%. Patients in Group 2 were given P at a dose of 1 mg/kg twice a day. The patients in Group 3 did not receive any treatment, and observation was conducted solely by contacting the controls. Results: The median age of diagnosis was 5 months (range 0-60), with 57.1% of the cases being male. While TM treatment was applied to 32% of the children and P treatment was applied to 46.9% of the children, no treatment was administered in 21.1%. The most common location of hemangiomas was the face, accounting for 39.2%. Hemangiomas were observed in more than one location in 48 (12%) children. The median follow-up period for the patients was 4 months (range 0-28). Hemangiomas remained unchanged in 28.3% of all cases, shrank in 60.3%, and continued to grow in 11.4%. The primary indication for initiating TM was superficial hemangiomas and infants younger than 6 months. The leading reason for starting P significantly higher than in the other groups (p : 0.001). No statistically significant differences were observed between the groups regarding bleeding and ulceration rates (p > 0.05). Conclusion: The efficacy of propranolol in treating IH was higher than that of TM.
{"title":"Oral topical timolol maleat or oral propranolol treatment for infantile hemangiomas: Clinical analysis of 403 patients","authors":"Özlem Terzi, Esra Arslantaş, Nur Baş, Ayşe Kaçar, Pasli Uysalol, Avni Solgun, Duygu Yıldırgan, Özkan Karagenç, Ertürk Saide, Ali Ayçiçek","doi":"10.5937/sanamed0-46005","DOIUrl":"https://doi.org/10.5937/sanamed0-46005","url":null,"abstract":"Objective: Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Propranolol (P), a nonselective beta-blocker, has been successfully used in managing IHs. Ongoing studies investigate the efficacy of the topical b-antagonist timolol maleate (TM) in IHs. The aim of this study is to assess the effects of interventions for managing infantile hemangiomas in children. Material and Methods: We retrospectively reviewed a total of 403 IH patients from March 2021 to March 2022. The patients were stratified into three groups. Patients in Group 1 were given TM at a dose of one drop topically twice a day, 0.5%. Patients in Group 2 were given P at a dose of 1 mg/kg twice a day. The patients in Group 3 did not receive any treatment, and observation was conducted solely by contacting the controls. Results: The median age of diagnosis was 5 months (range 0-60), with 57.1% of the cases being male. While TM treatment was applied to 32% of the children and P treatment was applied to 46.9% of the children, no treatment was administered in 21.1%. The most common location of hemangiomas was the face, accounting for 39.2%. Hemangiomas were observed in more than one location in 48 (12%) children. The median follow-up period for the patients was 4 months (range 0-28). Hemangiomas remained unchanged in 28.3% of all cases, shrank in 60.3%, and continued to grow in 11.4%. The primary indication for initiating TM was superficial hemangiomas and infants younger than 6 months. The leading reason for starting P significantly higher than in the other groups (p : 0.001). No statistically significant differences were observed between the groups regarding bleeding and ulceration rates (p > 0.05). Conclusion: The efficacy of propranolol in treating IH was higher than that of TM.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Survivin functions as an apoptosis inhibitor and a regulator of cell division. This study aimed to determine the correlation between survivin expression and clinicopathologic parameters of oral squamous cell carcinoma (OSCC) and determine its potential role in the progression/prognosis of this type of tumor. Materials and methods: Immunohistochemical analysis of survivin expression was performed on 45 surgically obtained paraffin-embedded tissue samples of OSCCs. Data on patients' gender, age, tumor grade, site and stage, disease recurrence, metastasis occurrence , and disease-free interval (DFI) were correlated to survivin expression. Results: Survivin immunoreactivity was observed in 77.8% of samples. No significant correlation between survivin expression and age (p = 0.087), gender (p = 0.334), tumor site (p = 0.175), presence of lymph node metastases (p = 0.201), or disease recurrence (p = 0.451) was found. Survivin expression was observed in well and moderately differentiated tumors and in all clinical stages (p = 0.139). Patients with low survivin expression had better survival rates than the group with medium and high survivin expression, i.e., there was a tendency of a shorter DFI in patients with higher expression of survivin (p = 0.065). Conclusion: There is a tendency for a shorter disease-free period in patients with higher survivin expression. These data suggest that survivin expression in OSCC may act as an additional prognostic parameter that indicates an increased proliferative tumor potential. To further validate survivin as a prognostic marker in OSCC, a study with a larger sample size along with clinical follow-up data is needed.
{"title":"Survivin expression in oral squamous cell carcinoma","authors":"Marija Antunović, Janja Raonić","doi":"10.5937/sanamed0-45111","DOIUrl":"https://doi.org/10.5937/sanamed0-45111","url":null,"abstract":"Introduction: Survivin functions as an apoptosis inhibitor and a regulator of cell division. This study aimed to determine the correlation between survivin expression and clinicopathologic parameters of oral squamous cell carcinoma (OSCC) and determine its potential role in the progression/prognosis of this type of tumor. Materials and methods: Immunohistochemical analysis of survivin expression was performed on 45 surgically obtained paraffin-embedded tissue samples of OSCCs. Data on patients' gender, age, tumor grade, site and stage, disease recurrence, metastasis occurrence , and disease-free interval (DFI) were correlated to survivin expression. Results: Survivin immunoreactivity was observed in 77.8% of samples. No significant correlation between survivin expression and age (p = 0.087), gender (p = 0.334), tumor site (p = 0.175), presence of lymph node metastases (p = 0.201), or disease recurrence (p = 0.451) was found. Survivin expression was observed in well and moderately differentiated tumors and in all clinical stages (p = 0.139). Patients with low survivin expression had better survival rates than the group with medium and high survivin expression, i.e., there was a tendency of a shorter DFI in patients with higher expression of survivin (p = 0.065). Conclusion: There is a tendency for a shorter disease-free period in patients with higher survivin expression. These data suggest that survivin expression in OSCC may act as an additional prognostic parameter that indicates an increased proliferative tumor potential. To further validate survivin as a prognostic marker in OSCC, a study with a larger sample size along with clinical follow-up data is needed.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"242 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136301432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emina Hadžimuratović, Admir Hadžimuratović, D. Pokrajac, S. Branković, Vedran Đido
Introduction:The diagnosis of acute kidney injury (AKI) in preterm newborns with perinatal asphyxia based on increased serum creatinine (sCr) value and oliguria/anuria is usually delayed. The Aim of this paper is to evaluate serum cystatin C as an early predictor of AKI. Materials and methods:The study included 42 preterm newborns (24-37 weeks) with perinatal asphyxia (Apgar score (AS) ≤ 3 at 5 minutes of life or blood pH on admission ≤ 7.00). The sCr and sCysC levels were measured on the 1st, 3rd, and 7th day of life. According to KDIGO criteria, the newborns were classified into groups, and sCr and sCys-C values were compared. Results:The mean gestational age was 29.9 ± 3.0 weeks. AKI was diagnosed in 62.8 % of patients. Of these patients, 81.5% belonged to AKI 1 group, and 18.5 % to AKI 2 group.No newborns had the criteria for AKI 3. On day 7 the mean sCr values were significantly higher in AKI (65.4± 21.8) compared with the non-AKI group (168.4±38.2) (p<0.001), but not on day 1 and 3 (p = 0.322, 0.012, respectively). The sCys-C values were significantly higher in the AKI group on day 3 ( AKI vs. non-AKI group, 0.69 ±0.22 vs. 1.22 ±0.20; p <0.001) and day 7 (AKI vs. non-AKI group, 0.62 ±0.41 vs. 1.68 ±0.20; p <0.001). The sCys-C was also an earlier marker of a more severe stage of AKI than sCr. Conclusion:The sCys-C was elevated earlier than sCr, making it a valuable diagnostic tool for AKI in preterm newborns.
基于血清肌酐(sCr)值升高和少尿/无尿，围产儿窒息的早产儿急性肾损伤(AKI)的诊断通常是延迟的。本文的目的是评估血清胱抑素C作为AKI的早期预测因子。材料与方法:选取42例围产期窒息早产儿(24 ~ 37周)(出生5分钟时Apgar评分(AS)≤3或入院时血液pH≤7.00)。分别于出生后第1、3、7天测定sCr和sCysC水平。根据KDIGO标准对新生儿进行分组，比较sCr和sCys-C值。结果:平均胎龄29.9±3.0周。62.8%的患者被诊断为AKI。其中AKI 1组占81.5%，AKI 2组占18.5%。没有新生儿有AKI 3的标准。第7天AKI组sCr平均值(65.4±21.8)显著高于非AKI组(168.4±38.2)(p<0.001)，第1天和第3天无显著差异(p分别为0.322和0.012)。AKI组sCys-C值在第3天显著升高(AKI组与非AKI组，0.69±0.22 vs 1.22±0.20;p <0.001)和第7天(AKI组vs.非AKI组，0.62±0.41 vs. 1.68±0.20;p < 0.001)。sCys-C也是比sCr更早的AKI严重阶段的标志。结论:sCys-C的升高早于sCr，可作为早产儿AKI的诊断工具。
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