Adverse Effects of Inactivated Foot-and-Mouth Disease Vaccine—Possible Causes Analysis and Countermeasures

Keshan Zhang, Bingzhou Lu, Huanan Liu, Jun-Yan Zhao, Haixue Zheng, Xiang-tao Liu
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引用次数: 2

Abstract

Foot-and-mouth disease (FMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, and Chinese government adopts compulsory immunization measures for FMD. The adverse effects of FMD vaccine to pigs, cattle and goats have been reported increasingly frequent during the spring and autumn seasons when large numbers of farm livestock are vaccinated. The financial losses caused by vaccine adverse effects have been a serious concern for both farmers and primary prevention personnel. There are various causative factors reported to involve into adverse effect of FMD vaccine, including the inappropriate vaccine production, transportation and storage, livestock poor tolerance, and unqualified vaccinating manipulations. Symptomatic treatment and early drug prevention have a certain effect on the adverse effects. To analyze causes and propose countermeasures, in the current study possible reasons during the production and processing procedures of inactivated FMD vaccine were reviewed and corresponding countermeasures were recommended. The review may provide references for better use of vaccine to prevent FMD.
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口蹄疫灭活疫苗不良反应的原因分析及对策
口蹄疫(FMD)是一种影响偶蹄动物的传染性、有时甚至致命的病毒性疾病,中国政府对口蹄疫采取强制免疫措施。据报道,口蹄疫疫苗对猪、牛和山羊的不良影响在春季和秋季日益频繁,因为在这两个季节,大量家畜接种了疫苗。疫苗不良反应造成的经济损失一直是农民和初级预防人员严重关切的问题。据报道,口蹄疫疫苗产生不良反应的原因多种多样,包括疫苗生产、运输和储存不当、牲畜耐受性差、接种操作不合格等。对症治疗和早期药物预防对不良反应有一定的作用。为分析原因并提出对策,本研究综述了口蹄疫灭活疫苗生产加工过程中可能出现的原因,并提出了相应的对策建议。该综述可为更好地利用疫苗预防口蹄疫提供参考。
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