Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months

疫苗(英文) Pub Date : 2023-01-01 DOI:10.21203/rs.3.rs-2093702/v1

Victoria Delicado-Useros, Esther Navarro-Rodenas, Indalecio-M Sánchez-Onrubia, Carmen Ortega-Martínez, Antonia Alfaro-Espín, J. Pérez-Serra, F. García-Alcaraz, Julia Lozano-Serra, Lorena Robles-Fonseca, Teresa Pérez-Domenech

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Abstract

Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods Observational study of medication on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti- SARS-CoV2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.

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全面接种SARS-CoV-2后获得性体液免疫的进化医护人员6个月和9个月IgG水平

背景:2019冠状病毒病大流行仍然是一个重大的全球卫生问题。本研究旨在监测疫苗对SARS-CoV-2的免疫和临床反应。方法观察用药对获得性免疫和疫苗有效性的影响。人口:阿尔曼萨保健服务人员620人(西班牙)。150个人的代表性样本。记录社会人口学、临床和流行病学资料和样本，以确定接种辉瑞疫苗后6个月和9个月的抗SARS-CoV2血清IgG水平。结果平均年龄46.45岁，女性占76%，85.1%在医院工作。19.3%的人在接种疫苗前一年感染了COVID-19。96.7%的人完全接种了辉瑞/BioNTech疫苗。6个月时，100%血清阳性，平均IgG水平3017.2 AU/ml。既往COVID-19感染个体和吸烟者中IgG水平的显著差异在9个月时，99.3%的人仍呈血清学阳性，2.8%的人在接种疫苗后感染。重复测量分析显示，两组差异均值为669.0 AU/ml (IgG水平显著降低28.9%)。结论接种后6个月和9个月抗体水平保持阳性，IgG水平下降。

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