Mechanisms of hepatic cancer by persistent organic pollutants

Abstract

Persistent organic pollutants (POPs) are a group of organic chemicals, as defined by the Stockholm Convention that are persistent in the environment and accumulate in organisms including humans. Most POPs are restricted in use or no longer manufactured because of this persistence, bioaccumulation, and toxicity. In addition, an association between POP exposure and human disease has been suggested. Regarding toxicological effects and particularly cancer, most POPs have been shown to induce hepatic tumors when chronically administered to rodents. Understanding the mechanisms by which POPs induce liver cancer is important in developing meaningful human cancer risk evaluation to these compounds. In this article, we have reviewed the probable mechanisms of hepatic cancer induced by POPs mode of action and molecular initiating events and the relationship of these mechanisms to potential human cancer risk.