Objective To investigate the clinicopathological characteristics of breast cancer with osteoclast like giant cells (COGC). Method: One COGC patient from Taizhou People's Hospital in Jiangsu Province in February 2016 and one COGC patient from Putuo District Central Hospital in Shanghai in May 2008 were collected, and their histological morphology, immune phenotype, and clinical pathological characteristics were observed. Relevant literature was reviewed. The results showed that both patients were female, aged 48 and 57 years respectively, and both sought medical attention due to painless breast masses. Under optical microscopy, the main manifestations are infiltrating cribriform carcinoma and non-specific infiltrating ductal carcinoma, with osteoclast like giant cells scattered within the tumor tissue, and varying degrees of bleeding and inflammatory cell infiltration in the stroma. Immunohistochemistry showed diffuse strong positivity of estrogen receptor (ER) and progesterone receptor (PR) in cancer cells, and CD68 positivity in osteoclast like giant cells. Conclusion: COGC is a rare tumor with a unique morphology of osteoclast like giant cells, which requires differentiation from multiple types of multinucleated giant cells. Its diagnosis and differential diagnosis need to be based on morphological characteristics and immune phenotype.
期刊介绍：
"Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association.
It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.
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