Hormonal Regulatory Impacts of Tinospora cordifolia Leaf Extract and Its Loaded Phytoniosome on Mifepristone-Induced Polycystic Ovarian Syndrome (PCOS) Rats – In Vivo Studies
S. Masilamani, Priya Chokkalingam, Meera B, R. Hari, M. P
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Abstract
ABSTRACT The effects of ethanolic leaf extract of Tinospora cordifolia (ELETC) and its loaded phytoniosomes (nELETC) on altered hormonal levels in female polycystic ovarian syndrome (PCOS) rats induced by mifepristone were investigated. Mifepristone (4 mg kg−1 b.w.) was given daily to female rats for 8 days to develop PCOS, which was then detected by a protracted estrous cycle. The treatment regimen for the rats with PCOS consisted of 200 mg kg−1 b.w. of ELETC and nELETC administered orally every day for 28 days. Hormone tests showed that metformin acted as a favorable control. Results demonstrated that ELETC and nELETC may be used as therapeutic alternatives for treating PCOS to decrease complications of hyperinsulinemia, insulin resistance, and hyperandrogenism.
期刊介绍：
The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.
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