One-pot mediated synthesis of pyrimidine and quinazoline annulated derivatives of nitrogen containing five membered rings through their nitrile derivatives as antibacterial agents

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Bulletin of the Chemical Society of Ethiopia Pub Date : 2023-06-30 DOI:10.4314/bcse.v37i5.12

Umang A. Gosalia, Manish Srivastava, Neetu Yaduvanshi, Shivangi Jaiswal, Sonika Jain, D. Kishore, J. Dwivedi, Swapnil Sharma

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Abstract

ABSTRACT. Novel five-membered ring (pyrrole, pyrazole and imidazole)-based pyrimidine and quinazoline derivatives were synthesized by one-pot domino approach. This approach has the advantages of high yield, mild reaction conditions and a simple work-up procedure. The structure of the synthesized compound was elucidated by spectroscopy technique and elemental analysis. The synthesized compound were examined for antimicrobial activity against four bacteria (E. coli, S. pyogenes, S. aureus, and P. aeruginosa) and two fungi (C. albicans and A. clavatus) and most of the synthesized compound exhibited moderate to good activity against reference drug ampicillin, ciprofloxacin, norfloxacin, gentamycin, nystatin and griseofulvin, respectively. KEY WORDS: One-pot, Pyrrole, Pyrazole, Imidazole, Pyrimidine, Quinazoline, Antimicrobial activity Bull. Chem. Soc. Ethiop. 2023, 37(5), 1193-1208. DOI: https://dx.doi.org/10.4314/bcse.v37i5.12

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一锅催化合成含氮五元环的嘧啶和喹唑啉环衍生物及其腈衍生物作为抗菌剂

摘要。采用一锅多米诺法合成了新型的五元环（吡咯、吡唑和咪唑）基嘧啶和喹唑啉衍生物。该方法具有产率高、反应条件温和和后处理程序简单的优点。通过光谱技术和元素分析对合成的化合物进行了结构鉴定。检测了合成的化合物对四种细菌（大肠杆菌、化脓性链球菌、金黄色葡萄球菌和铜绿假单胞菌）和两种真菌（白色念珠菌和棒曲霉）的抗菌活性，并且大多数合成的化合物分别对参比药物氨苄青霉素、环丙沙星、诺氟沙星、庆大霉素、制霉菌素和灰黄霉素表现出中等至良好的活性。关键词：一锅，吡咯，吡唑，咪唑，嘧啶，喹唑啉，抗菌活性牛。化学。Soc.Ethiop。2023,37（5），1193-1208.DOI:https://dx.doi.org/10.4314/bcse.v37i5.12

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.