{"title":"Advances in coagulation compensation mechanisms of patients with immune thrombocytopenia","authors":"Yanbin Xiao, Shu-chuan Liu","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.01.006","DOIUrl":null,"url":null,"abstract":"Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease involving increased platelet destruction and insufficient platelet production, leading to thrombocytopenia, with or without clinical manifestations of bleeding. Although thrombocytopenia may cause coagulation dysfunction and hemorrhagic complications, the bleeding severity is not certainly proportional to the number of platelets. In some cases, there is no significant bleeding symptom even the platelet count is extremely low, which suggests there are additional compensatory mechanisms to control or ameliorate the bleeding complications in ITP patients. The present article aims to review recent investigations on the compensatory mechanisms of coagulation function in the patients with ITP. \n \n \nKey words: \nThrombocytopenia; Microsomes; Phosphatidylserines; Thromboplastin; Platelet membrane glycoproteins; Thrombin; Interleukin-6","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"36-40"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.01.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Immune thrombocytopenia (ITP) is an acquired autoimmune hemorrhagic disease involving increased platelet destruction and insufficient platelet production, leading to thrombocytopenia, with or without clinical manifestations of bleeding. Although thrombocytopenia may cause coagulation dysfunction and hemorrhagic complications, the bleeding severity is not certainly proportional to the number of platelets. In some cases, there is no significant bleeding symptom even the platelet count is extremely low, which suggests there are additional compensatory mechanisms to control or ameliorate the bleeding complications in ITP patients. The present article aims to review recent investigations on the compensatory mechanisms of coagulation function in the patients with ITP.
Key words:
Thrombocytopenia; Microsomes; Phosphatidylserines; Thromboplastin; Platelet membrane glycoproteins; Thrombin; Interleukin-6
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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