Y. Kim, Na‐Hyun Kim, Onevilay Souliya, Uddin Salah, S. Lee, Soo-Yong Kim, S. Choi, J. Heo, E. Jeong
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引用次数: 0
Abstract
The therapeutic effects of the leaves of Couroupita guianensis , a large tropical tree in the family of Lecythidaceae improving testosterone-induced Benign Prostatic Hyperplasia (BPH) were tested in vitro and in vivo . In BPH rats induced by castration and testosterone treatment, the prostate index was improved in groups administered with the extracts of C. guianensis extracted with 50%-, 100%-ethanol or boiling water, which was comparable with positive control, finasteride. The extract C. guianensis leaves showed significant inhibition on the expressions of type 2 5-alpha reductase (5αR) in RWPE-1 human prostatic epithelial cells, and effectively attenuated the expressions of androgen receptor, type 2 5αR and proliferating cell nuclear antigen in LNCap human prostatic adenocarcinoma cells. The leaves of C. guianensis that exerted evident suppression on BPH-related biomarkers in vitro and improvement of prostate index in vivo has a potential therapeutic use for the treatment of BPH
期刊介绍：
Natural Product Sciences is the official publication of the Korean Society of Pharmacognosy which was launched in 1995. The journal is published quarterly at the end of March, June, September, and December each year and the official title of the journal is abbreviated title as "Nat. Prod. Sci." The research papers on original work, either experimental or theoretical, that advance our understanding of natural product sciences, including important questions of phytochemistry, chemistry, and bio-chemistry of natural resources will be published. Timely reviews and commentaries on recent progress in active areas of natural products research will be also published.
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