Aeollanthus pubescens Benth. (Lamiaceae) is a herbaceous plant that is native to West Africa. It is commonly used in cooking and traditional healing in some parts of Togo and Benin. This study analyzed the chemical compositions of essential oils obtained from different parts of Togo (Kozah, Est-Mono, and Ogou) using gas chromatography-mass spectrometry. Additionally, the study investigated the bioactivity of essential oils and water extracts on the cowpea weevil Callosobruchus maculatus, plant parasitic nematode Meloidogyne incognita, and two plant seeds, Sesamum indicum, and Pennisetum glaucum, regarding germination inhibition. The results showed that the major components of the different essential oils were thymol (55.02%) and thymol acetate (20.03%) for Kozah, D-fenchone (65.05%) for Est-Mono, and thymol (29.48%), carvacrol (20.93%), thymol acetate (16.98%), and carvacryl acetate (13.14%) for Ogou. The Est-Mono essential oil was the most effective in controlling cowpea weevils with an EC50 value of 3.1 ± 0.6 μL/L air. Kozah and Ogou essential oils showed more potent nematicidal activity with ECSUB50/72h/SUB values of 305.4 ± 7.3 mg/L and 275.6 ± 2.6 mg/L, respectively, while Est-Mono essential oil did not exhibit any activity. Finally, the Kozah and Ogou essential oils were found to inhibit the germination of dicotyledonous S. indicum seeds by more than 80% at 10 mg/mL, while less germicidal activity was observed on the monocotyledon P. glaucum from the different essential oils. These findings suggest that extracts of A. pubescens could be used in agriculture as a biopesticide.
{"title":"Bioactivity and Chemical Composition of Essential Oils from Three Chemotypes of Aeollanthus pubescens Benth","authors":"Kodjo Eloh, Oudjaniyobi Simalou, Sassou Mégnassan, Hélène Afantchao, Marie-France Bakaï, Koffi Koba, Pierluigi Caboni","doi":"10.20307/nps.2023.29.3.162","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.162","url":null,"abstract":"Aeollanthus pubescens Benth. (Lamiaceae) is a herbaceous plant that is native to West Africa. It is commonly used in cooking and traditional healing in some parts of Togo and Benin. This study analyzed the chemical compositions of essential oils obtained from different parts of Togo (Kozah, Est-Mono, and Ogou) using gas chromatography-mass spectrometry. Additionally, the study investigated the bioactivity of essential oils and water extracts on the cowpea weevil Callosobruchus maculatus, plant parasitic nematode Meloidogyne incognita, and two plant seeds, Sesamum indicum, and Pennisetum glaucum, regarding germination inhibition. The results showed that the major components of the different essential oils were thymol (55.02%) and thymol acetate (20.03%) for Kozah, D-fenchone (65.05%) for Est-Mono, and thymol (29.48%), carvacrol (20.93%), thymol acetate (16.98%), and carvacryl acetate (13.14%) for Ogou. The Est-Mono essential oil was the most effective in controlling cowpea weevils with an EC50 value of 3.1 ± 0.6 μL/L air. Kozah and Ogou essential oils showed more potent nematicidal activity with ECSUB50/72h/SUB values of 305.4 ± 7.3 mg/L and 275.6 ± 2.6 mg/L, respectively, while Est-Mono essential oil did not exhibit any activity. Finally, the Kozah and Ogou essential oils were found to inhibit the germination of dicotyledonous S. indicum seeds by more than 80% at 10 mg/mL, while less germicidal activity was observed on the monocotyledon P. glaucum from the different essential oils. These findings suggest that extracts of A. pubescens could be used in agriculture as a biopesticide.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135083719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.132
Se-Hwan Ryu, Beom-Seok Kim, Ayman Turk, Sang-Won Yeon, Solip Lee, Hak-Hyun Lee, Sung-Min Ko, Bang Yeon Hwang, Mi Kyeong Lee
Hericium erinaceus, also known as lion’s mane mushroom, is an edible and medicinal mushroom that belongs to the family Hericiaceae. We previously reported hericene A as an anti-diabetic constituent of H. erinaceus and the effect of cultivation substrates on its content was investigated. As the continuation, the contents of five major compounds such as hericenes A-D, which exerted α-glucosidase inhibitory activity, together with ergosterol were investigated depending on cultivation stages. H. erinaceus was cultured for 25 days (5 stages) to induce fruiting bodies, and the contents of the compounds at each stage were quantified. All the five compounds were detected in fruiting body by HPLC analysis. Among the hericene derivatives in the mushroom, the content of hericene A was the highest, followed by hericene C and the content of hericenes B and D was relative low. All four hericene derivatives present in the highest content at stage 4 whereas the content of ergosterol was highest at stage 5. The highest α-glucosidase inhibitory activity of H. erinaceus was measured at stage 4, which correlates with the contents of hericene derivatives. Conclusively, H. erinaceus with better efficacy and high content of active constituents can be secured by the optimization of cultivation conditions.
{"title":"Effect of Cultivation Stages of Hericium erinaceus on the Contents of Major Components and α-Glucosidase Inhibitory Activity","authors":"Se-Hwan Ryu, Beom-Seok Kim, Ayman Turk, Sang-Won Yeon, Solip Lee, Hak-Hyun Lee, Sung-Min Ko, Bang Yeon Hwang, Mi Kyeong Lee","doi":"10.20307/nps.2023.29.3.132","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.132","url":null,"abstract":"Hericium erinaceus, also known as lion’s mane mushroom, is an edible and medicinal mushroom that belongs to the family Hericiaceae. We previously reported hericene A as an anti-diabetic constituent of H. erinaceus and the effect of cultivation substrates on its content was investigated. As the continuation, the contents of five major compounds such as hericenes A-D, which exerted α-glucosidase inhibitory activity, together with ergosterol were investigated depending on cultivation stages. H. erinaceus was cultured for 25 days (5 stages) to induce fruiting bodies, and the contents of the compounds at each stage were quantified. All the five compounds were detected in fruiting body by HPLC analysis. Among the hericene derivatives in the mushroom, the content of hericene A was the highest, followed by hericene C and the content of hericenes B and D was relative low. All four hericene derivatives present in the highest content at stage 4 whereas the content of ergosterol was highest at stage 5. The highest α-glucosidase inhibitory activity of H. erinaceus was measured at stage 4, which correlates with the contents of hericene derivatives. Conclusively, H. erinaceus with better efficacy and high content of active constituents can be secured by the optimization of cultivation conditions.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.127
Juree Kim, Neil Patrick Uy, Doyun Kim, Sanghyun Lee
Chestnut honey contains various components such as phenolic compounds and alkaloids that exhibit antioxidant and anti-inflammatory activities. However, the composition and activity of chestnut honey significantly differ depending on its region of origin. In this study, the antioxidant activity of chestnut honey obtained from nine regions in Korea was evaluated by ABTS free radical scavenging assay. In addition, the phenolic acid content of each honey sample was analyzed using high-performance liquid chromatography (HPLC) and an ultraviolet (UV) detector. The antioxidant activity increased with the increasing concentration of chestnut honey samples. The major phenolic compounds in chestnut honey were observed to be gallic, pcoumaric, and ferulic acid. Altogether, the quantitative analysis of phenolic acids and evaluation of antioxidant activity in chestnut honey from different regions will contribute to establishing regional chestnut honey profiling in Korea and may provide preliminary data for collecting honey with various biological activities.
{"title":"Analysis of Phenolic Acid Content and Antioxidant Activity of Chestnut Honey from Different Regions of Korea","authors":"Juree Kim, Neil Patrick Uy, Doyun Kim, Sanghyun Lee","doi":"10.20307/nps.2023.29.3.127","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.127","url":null,"abstract":"Chestnut honey contains various components such as phenolic compounds and alkaloids that exhibit antioxidant and anti-inflammatory activities. However, the composition and activity of chestnut honey significantly differ depending on its region of origin. In this study, the antioxidant activity of chestnut honey obtained from nine regions in Korea was evaluated by ABTS free radical scavenging assay. In addition, the phenolic acid content of each honey sample was analyzed using high-performance liquid chromatography (HPLC) and an ultraviolet (UV) detector. The antioxidant activity increased with the increasing concentration of chestnut honey samples. The major phenolic compounds in chestnut honey were observed to be gallic, pcoumaric, and ferulic acid. Altogether, the quantitative analysis of phenolic acids and evaluation of antioxidant activity in chestnut honey from different regions will contribute to establishing regional chestnut honey profiling in Korea and may provide preliminary data for collecting honey with various biological activities.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.182
Sae-Rom Park, Young-Ho Kim, Seo Young Yang
Ecklonia cava Kjellman (Laminareaceae) grows along the coast of Jeju Island, Korea, and is wellknown in Korea for its use as a food ingredient, animal feed, and medicine. This seaweed contains phlorotannins, polymerized units of phloroglucinol, a term derived from phloroglucinol, the building block of these complex molecules, which is also the common name for these compounds. Phlorotannins are secondary metabolites that hold significance for human health due to their various beneficial properties, including antioxidant, anti-cancer, anti-allergy, and anti-HIV activities. In this study, 10 phlorotannins (1–10) were isolated from an 80% EtOH extract of E. cava. The structures of these compounds were determined through spectroscopic analysis and comparison with the literature. The inhibitory effects of compounds 1–10 on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were investigated. In an AChE inhibition assay, compounds 1, 2, 4, and 6–10 had ICSUB50/SUB values ranging from 0.9 ± 0.8 to 66.5 ± 0.4 μM; compounds 4, 6, and 9 had potent BuChE inhibitory effects, with ICSUB50/SUB values ranging from 1.4 ± 3.8 to 25.2 ± 0.1 μM. Furthermore, enzyme kinetics and molecular docking simulations were conducted to gain insights into the inhibition mode, binding mechanism, and crucial interactions between these active compounds and the target enzyme. This indicates that E. cava is a potentially valuable natural source of AChE and BuChE inhibitors.
{"title":"Enzyme Kinetics and Molecular Docking Investigation of Acetylcholinesterase and Butyrylcholinesterase Inhibitors from the Marine Alga Ecklonia cava","authors":"Sae-Rom Park, Young-Ho Kim, Seo Young Yang","doi":"10.20307/nps.2023.29.3.182","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.182","url":null,"abstract":"Ecklonia cava Kjellman (Laminareaceae) grows along the coast of Jeju Island, Korea, and is wellknown in Korea for its use as a food ingredient, animal feed, and medicine. This seaweed contains phlorotannins, polymerized units of phloroglucinol, a term derived from phloroglucinol, the building block of these complex molecules, which is also the common name for these compounds. Phlorotannins are secondary metabolites that hold significance for human health due to their various beneficial properties, including antioxidant, anti-cancer, anti-allergy, and anti-HIV activities. In this study, 10 phlorotannins (1–10) were isolated from an 80% EtOH extract of E. cava. The structures of these compounds were determined through spectroscopic analysis and comparison with the literature. The inhibitory effects of compounds 1–10 on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were investigated. In an AChE inhibition assay, compounds 1, 2, 4, and 6–10 had ICSUB50/SUB values ranging from 0.9 ± 0.8 to 66.5 ± 0.4 μM; compounds 4, 6, and 9 had potent BuChE inhibitory effects, with ICSUB50/SUB values ranging from 1.4 ± 3.8 to 25.2 ± 0.1 μM. Furthermore, enzyme kinetics and molecular docking simulations were conducted to gain insights into the inhibition mode, binding mechanism, and crucial interactions between these active compounds and the target enzyme. This indicates that E. cava is a potentially valuable natural source of AChE and BuChE inhibitors.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.121
Samy K. El-Desouky
The phytochemical investigation of the ethyl acetate fraction of the methanol seed extract of Salvadora persica resulted in the isolation and identification of five pentacyclic triterpenes (1-5), oleanolic acid (1), ursolic acid (2), β-amyrin (3), β-amyrin acetate (4) and lupeol tricosanoate (5). The structures of these compounds were established by the analysis of their NMR spectroscopic and mass spectrometric data. In the bioactivity assay, compound 5 showed moderate cytotoxic activities against breast cancer cell lines (MCF-7), colon cancer cell lines (HT-29) and hepatocellular carcinoma cell lines (HepG2) with IC50 values of 9.4, 6.85 and 12.74 μg/mL. respectively. In all previous studies, lupeol tricosanoate (5) has been isolated as a mixture of triterpenoid long-chain fatty acid esters and this is the first report of its isolation and characterization as a pure molecule. Moreover, the occurrence of fatty acid ester of triterpene in this plant is of taxonomic importance.
{"title":"A Cytotoxic Lupeol Fatty Acid Ester and Other Pentacyclic Triterpenes from Salvadora persica Seeds","authors":"Samy K. El-Desouky","doi":"10.20307/nps.2023.29.3.121","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.121","url":null,"abstract":"The phytochemical investigation of the ethyl acetate fraction of the methanol seed extract of Salvadora persica resulted in the isolation and identification of five pentacyclic triterpenes (1-5), oleanolic acid (1), ursolic acid (2), β-amyrin (3), β-amyrin acetate (4) and lupeol tricosanoate (5). The structures of these compounds were established by the analysis of their NMR spectroscopic and mass spectrometric data. In the bioactivity assay, compound 5 showed moderate cytotoxic activities against breast cancer cell lines (MCF-7), colon cancer cell lines (HT-29) and hepatocellular carcinoma cell lines (HepG2) with IC50 values of 9.4, 6.85 and 12.74 μg/mL. respectively. In all previous studies, lupeol tricosanoate (5) has been isolated as a mixture of triterpenoid long-chain fatty acid esters and this is the first report of its isolation and characterization as a pure molecule. Moreover, the occurrence of fatty acid ester of triterpene in this plant is of taxonomic importance.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.138
Darlene Mae D. Ortiz, Hyeyeon Oh, Soonyong Kwon, Eunseon Jeon, Kamal Hossain Muhammad, Hee-in Kim, Mikyung Kim
Sleep deprivation or insomnia is one of the most common but neglected health conditions, with serious long-term consequences. In addition, insomnia is linked to poor work performance, impaired memory, and lack of concentration. Improving sleep quality is a crucial aspect of health care. Hypnotic agents, such as benzodiazepines, antidepressants, and antihistamines, are often used to enhance sleep quality; however, these medications often result in tolerance and dependence, resulting in withdrawal syndrome upon discontinuation. In recent years, studies have focused on natural and herbal therapies as alternative sleep aids to overcome the adverse effects of available sleep medications. Plant extracts contain phytochemicals that exert anxiolytic and sedative properties. This includes Passiflora incarnata (FSD-PI) and Lactuca sativa L. (FSD-LS) which can induce sleep. Herein, we assessed the effects of natural products, FSD-PI and FSD-LS, as well as their synergistic effects on pentobarbital sleep-induced ICR mice. We observed that natural extracts did not cause any behavioral changes capable of negative effects in mice. Furthermore, sleep duration was prolonged in pentobarbital-treated mice administered with FSD-LS (100 mg/kg). Our data suggest that FSD-LS may be a safe and effective sleep promoter.
{"title":"Sleep-potentiating Effects of Passiflora incarnata and ‘Heukharang’, a Novel Korean Lactuca sativa, on Pentobarbital-induced Sleep in Mice","authors":"Darlene Mae D. Ortiz, Hyeyeon Oh, Soonyong Kwon, Eunseon Jeon, Kamal Hossain Muhammad, Hee-in Kim, Mikyung Kim","doi":"10.20307/nps.2023.29.3.138","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.138","url":null,"abstract":"Sleep deprivation or insomnia is one of the most common but neglected health conditions, with serious long-term consequences. In addition, insomnia is linked to poor work performance, impaired memory, and lack of concentration. Improving sleep quality is a crucial aspect of health care. Hypnotic agents, such as benzodiazepines, antidepressants, and antihistamines, are often used to enhance sleep quality; however, these medications often result in tolerance and dependence, resulting in withdrawal syndrome upon discontinuation. In recent years, studies have focused on natural and herbal therapies as alternative sleep aids to overcome the adverse effects of available sleep medications. Plant extracts contain phytochemicals that exert anxiolytic and sedative properties. This includes Passiflora incarnata (FSD-PI) and Lactuca sativa L. (FSD-LS) which can induce sleep. Herein, we assessed the effects of natural products, FSD-PI and FSD-LS, as well as their synergistic effects on pentobarbital sleep-induced ICR mice. We observed that natural extracts did not cause any behavioral changes capable of negative effects in mice. Furthermore, sleep duration was prolonged in pentobarbital-treated mice administered with FSD-LS (100 mg/kg). Our data suggest that FSD-LS may be a safe and effective sleep promoter.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.171
Viet Phong Nguyen, Ha-Yeong Chae, Vu Thi Oanh, Byung-Sun Min, Mi-Jeong Kwon, Jeong-Ah Kim
Ovarian cancer is a primary global health concern, often diagnosed at advanced stages with limited treatment options and poor prognosis. Natural products have emerged as potential sources of safe and effective therapies. From the seeds of Myristica fragrans Houtt. (nutmeg), 24 compounds, including neolignans and diarylnonanoid derivatives, were isolated and structurally elucidated. The cytotoxic activities of these isolated metabolites against cisplatin-sensitive and resistant human ovarian cancer cell lines were evaluated. In particular, myrifragranone C (23) exhibited cytotoxicity against all test cancer cell lines A2780, TOV-112D, and SK-OV3 with ICSUB50/SUB values of 14.1, 16.9, and 33.4 M, respectively. Furthermore, compound 23 induced the death of A2780 and SK-OV3 cancer cells via apoptosis. Western blotting revealed that compound 23 significantly increased the expression of cleaved caspase-3 and poly-ADP ribose polymerase and promoted apoptosis via the mitogenactivated protein kinase signaling pathway. Our findings may provide a preliminary understanding of the antiovarian cancer effect of the active compound myrifragranone C as a potential treatment using natural products.
{"title":"Cytotoxic Activities on Human Ovarian Cancer Cell Lines by Neolignans and Diarylnonanoids from the Seed of Myristica fragrans Houtt","authors":"Viet Phong Nguyen, Ha-Yeong Chae, Vu Thi Oanh, Byung-Sun Min, Mi-Jeong Kwon, Jeong-Ah Kim","doi":"10.20307/nps.2023.29.3.171","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.171","url":null,"abstract":"Ovarian cancer is a primary global health concern, often diagnosed at advanced stages with limited treatment options and poor prognosis. Natural products have emerged as potential sources of safe and effective therapies. From the seeds of Myristica fragrans Houtt. (nutmeg), 24 compounds, including neolignans and diarylnonanoid derivatives, were isolated and structurally elucidated. The cytotoxic activities of these isolated metabolites against cisplatin-sensitive and resistant human ovarian cancer cell lines were evaluated. In particular, myrifragranone C (23) exhibited cytotoxicity against all test cancer cell lines A2780, TOV-112D, and SK-OV3 with ICSUB50/SUB values of 14.1, 16.9, and 33.4 M, respectively. Furthermore, compound 23 induced the death of A2780 and SK-OV3 cancer cells via apoptosis. Western blotting revealed that compound 23 significantly increased the expression of cleaved caspase-3 and poly-ADP ribose polymerase and promoted apoptosis via the mitogenactivated protein kinase signaling pathway. Our findings may provide a preliminary understanding of the antiovarian cancer effect of the active compound myrifragranone C as a potential treatment using natural products.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.146
Ji-Yeon Lee, Yoon-A Kang, Ji-Yeong Bae
Daphne jejudoensis, an endemic plant found in Gotjawal area in Jeju Island, was reported as a new species in 2013 due to its distinct characteristics and distribution, which differentiate it from its related species, D. kiusiana. This study focuses on the comparative phytochemical analysis and antioxidant activities of D. jejudoensis leaves based on the collection period in order to identify the optimal harvest time. Daphnin and daphnetin were identified as the major components with the highest content observed in samples collected during spring, and the highest antioxidant activities were recorded during the same time period. This study represents the first investigation into the quantitative analysis of daphnin and daphnetin in the leaves of D. jejudoensis based on the collection period.
{"title":"Seasonality of Coumarin Composition and Antioxidant Activities in Daphne jejudoensis","authors":"Ji-Yeon Lee, Yoon-A Kang, Ji-Yeong Bae","doi":"10.20307/nps.2023.29.3.146","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.146","url":null,"abstract":"Daphne jejudoensis, an endemic plant found in Gotjawal area in Jeju Island, was reported as a new species in 2013 due to its distinct characteristics and distribution, which differentiate it from its related species, D. kiusiana. This study focuses on the comparative phytochemical analysis and antioxidant activities of D. jejudoensis leaves based on the collection period in order to identify the optimal harvest time. Daphnin and daphnetin were identified as the major components with the highest content observed in samples collected during spring, and the highest antioxidant activities were recorded during the same time period. This study represents the first investigation into the quantitative analysis of daphnin and daphnetin in the leaves of D. jejudoensis based on the collection period.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.20307/nps.2023.29.3.152
Kyung-Ho Lee, Geonha Park, Sangjae Lee, Yung-Gyo Lee, Minsik Choi, Roun Lee, Young-Pyo Jang
In this study, we have successfully established a high-performance thin-layer chromatography (HPTLC) method for the quality assessment of Actinidiae Fructus Vermicultus, known as Mokcheonryo(ja) in Korea. This is the dried vermiculate fruit of Actinidia polygama and A. kolomikta, as stipulated by the Korean Herbal Pharmacopoeia (KHP). However, the Korean herbal market often witnesses the inclusion and distribution of ‘Mihudo’, an alternative herbal product sourced from the dried fruits of A. arguta, belonging to the same botanical genus. This confluence has raised substantial apprehensions concerning the veracity of quality. In response to this concern, we have meticulously developed an HPTLC analytical methodology capable of differentiation between Mokcheonryo and Mihudo by exploiting their distinct chemical profiles. We identified umbelliferone as a key marker compound for Mokcheonryo and quantified the content of umbelliferone in each sample using a TLC scanner. Throughout this study, we confirmed distinct fingerprints for Mokcheonryo and Mihudo, providing a reliable means to differentiate between these two herbal medicines. Furthermore, the presence of umbelliferone in Mokcheonryo serves as an indicator compound for quality assessment. The proposed HPTLC method offers a practical and effective tool for ensuring the quality and authenticity of Mokcheonryo in the herbal market.
{"title":"Development of High-performance Thin-layer Chromatography (HPTLC) Method for Quality Control of Actinidiae Fructus Vermicultus","authors":"Kyung-Ho Lee, Geonha Park, Sangjae Lee, Yung-Gyo Lee, Minsik Choi, Roun Lee, Young-Pyo Jang","doi":"10.20307/nps.2023.29.3.152","DOIUrl":"https://doi.org/10.20307/nps.2023.29.3.152","url":null,"abstract":"In this study, we have successfully established a high-performance thin-layer chromatography (HPTLC) method for the quality assessment of Actinidiae Fructus Vermicultus, known as Mokcheonryo(ja) in Korea. This is the dried vermiculate fruit of Actinidia polygama and A. kolomikta, as stipulated by the Korean Herbal Pharmacopoeia (KHP). However, the Korean herbal market often witnesses the inclusion and distribution of ‘Mihudo’, an alternative herbal product sourced from the dried fruits of A. arguta, belonging to the same botanical genus. This confluence has raised substantial apprehensions concerning the veracity of quality. In response to this concern, we have meticulously developed an HPTLC analytical methodology capable of differentiation between Mokcheonryo and Mihudo by exploiting their distinct chemical profiles. We identified umbelliferone as a key marker compound for Mokcheonryo and quantified the content of umbelliferone in each sample using a TLC scanner. Throughout this study, we confirmed distinct fingerprints for Mokcheonryo and Mihudo, providing a reliable means to differentiate between these two herbal medicines. Furthermore, the presence of umbelliferone in Mokcheonryo serves as an indicator compound for quality assessment. The proposed HPTLC method offers a practical and effective tool for ensuring the quality and authenticity of Mokcheonryo in the herbal market.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135084838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.20307/nps.2023.29.2.59
Rui Jiang, Soohyun Um, Hyeongju Jeong, Jeongwon Seo, M. Huh, Young-ran Kim, K. Moon
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