Application of Chemical Engineering Methodology in Process Development: A Case Study of MenD-catalyzed Synthesis of 6-Cyano-4-oxohexanoic Acid

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Chemical and Biochemical Engineering Quarterly Pub Date : 2019-01-17 DOI:10.15255/CABEQ.2018.1393

M. Sudar, I. Dejanović, Michael Vasić-Rački Đurđa Müller, Z. Blažević

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引用次数: 1

Abstract

To speed up evaluation, development and upscaling of new processes, the use of engineering methodology can have a great impact. Here we show the application of an engineering approach to find the reaction conditions allowing the best process metrics. An experimentally validated mathematical model for the MenD-catalyzed synthesis of a commercially unavailable product 6-cyano-4- oxohexanoic acid, with a potential industrial use as a building block, was used for process optimization. Using the optimized conditions, 62.4 g dm3 of product, volume productivity of 87.1 g dm3 d1, product yield of 96 % and biocatalyst productivity of 25.8 kgP kgMenD1 can be achieved. Based on the optimized production procedure, economic analysis was performed to determine minimal product price required for project to be profitable in 8 years economic lifetime. In addition, Monte Carlo analysis (MCA) was used to assess the influence of uncertainties in estimation of input variables on overall economic performance.

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化学工程方法在工艺开发中的应用——以mend催化合成6-氰基-4-氧己酸为例

为了加快新工艺的评估、开发和升级，工程方法论的使用可以产生巨大影响。在这里，我们展示了工程方法的应用，以找到允许最佳工艺指标的反应条件。一个实验验证的数学模型用于MenD催化合成商业上不可用的产品6-氰基-4-氧代己酸，该产品具有潜在的工业用途作为构建块，用于工艺优化。使用优化的条件，62.4 g dm产品的3，体积生产率为87.1克dm3天1，产品收率为96%，生物催化剂生产率为25.8 kgP kgMenD1。在优化生产程序的基础上，进行了经济分析，以确定项目在8年经济寿命内盈利所需的最低产品价格。此外，还使用蒙特卡罗分析（MCA）来评估投入变量估计中的不确定性对整体经济绩效的影响。

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来源期刊

Chemical and Biochemical Engineering Quarterly 工程技术-工程：化工

CiteScore

2.70

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The journal provides an international forum for presentation of original papers, reviews and discussions on the latest developments in chemical and biochemical engineering. The scope of the journal is wide and no limitation except relevance to chemical and biochemical engineering is required. The criteria for the acceptance of papers are originality, quality of work and clarity of style. All papers are subject to reviewing by at least two international experts (blind peer review). The language of the journal is English. Final versions of the manuscripts are subject to metric (SI units and IUPAC recommendations) and English language reviewing. Editor and Editorial board make the final decision about acceptance of a manuscript. Page charges are excluded.