Pub Date : 2024-07-15DOI: 10.15255/cabeq.2023.2279
J. Hassen, J. Silver
Porphyrins are a group of organic heterocyclic macromolecules, composed of four modified pyrrole subunits interconnected at their α carbon atoms via methine bridges. This unique and significant group of compounds has a special relationship with inorganic clay minerals, which are hydrous aluminium phyllosilicates. Clay minerals, known to be typical layered materials, act as unique hosts for porphyrin molecules or their precursor materials. When the porphyrin compound enters between the layers of a clay, it can orient horizontally, diagonally, or perpendicularly. Cation-exchanged clay can provide the acidity required for the formation of porphyrins from its precursor molecules without the need for other auxiliary factors such as heating. Clays are also capable of facilitating the incorporation of various metals into the porphyrin ring to form a metalloporphyrin. The properties of these metalloporphyrin clay complexes have been studied extensively. Modern applications of such clay-porphyrin materials include their use as heterogeneous catalysts for oxidation and polymerization reactions in the synthesis of new materials. These heterogeneous catalysts have a wide range of uses in vital sectors, such as food manufacturing, pharmaceuticals, and the chemical industry. Additionally, clay-porphyrin systems are employed in constructing various types of self-assembling artificial photo-synthesis systems.
{"title":"The Unique Structure–Activity Relationship of Porphyrins and Clay Mineral Systems in Modern Applications: A Comprehensive Review","authors":"J. Hassen, J. Silver","doi":"10.15255/cabeq.2023.2279","DOIUrl":"https://doi.org/10.15255/cabeq.2023.2279","url":null,"abstract":"Porphyrins are a group of organic heterocyclic macromolecules, composed of four modified pyrrole subunits interconnected at their α carbon atoms via methine bridges. This unique and significant group of compounds has a special relationship with inorganic clay minerals, which are hydrous aluminium phyllosilicates. Clay minerals, known to be typical layered materials, act as unique hosts for porphyrin molecules or their precursor materials. When the porphyrin compound enters between the layers of a clay, it can orient horizontally, diagonally, or perpendicularly. Cation-exchanged clay can provide the acidity required for the formation of porphyrins from its precursor molecules without the need for other auxiliary factors such as heating. Clays are also capable of facilitating the incorporation of various metals into the porphyrin ring to form a metalloporphyrin. The properties of these metalloporphyrin clay complexes have been studied extensively. Modern applications of such clay-porphyrin materials include their use as heterogeneous catalysts for oxidation and polymerization reactions in the synthesis of new materials. These heterogeneous catalysts have a wide range of uses in vital sectors, such as food manufacturing, pharmaceuticals, and the chemical industry. Additionally, clay-porphyrin systems are employed in constructing various types of self-assembling artificial photo-synthesis systems.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.15255/cabeq.2024.2297
Nikola Šoltýsová, Jakub Jurík, Ronald Zakhar, Ján Derco
,
,
{"title":"Decolorization of Wastewater from Pulp and Paper Industry by Adsorption on Talc","authors":"Nikola Šoltýsová, Jakub Jurík, Ronald Zakhar, Ján Derco","doi":"10.15255/cabeq.2024.2297","DOIUrl":"https://doi.org/10.15255/cabeq.2024.2297","url":null,"abstract":",","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.15255/cabeq.2024.2290
Elsevar Mikayilov, Nizami Zeynalov, D. Taghiyev, Shamil Taghiyev
Nanoparticle formulation development for drug delivery, a crucial aspect of nano-technology, encounters numerous challenges. These encompass selecting appropriate excipients, comprehending miscibility and solubility factors, ensuring efficient drug encapsulation and release, assessing stability, and facilitating drug transport in the bloodstream for accurate targeting and attachment. To address these intricate issues, a range of molecular computational models is utilized. These models include quantum mechanical simulations that handle the smallest particles and move through atomistic molecular dynamics for detailed molecular interactions, coarse-grained molecular dynamics (MD) for larger scale phenomena, and dissipative particle dynamics (DPD) for mesoscale modeling. Further scaling up, computational fluid dynamics (CFD) is used for fluidic behaviors, discrete element modeling for large particle systems, and both pharmacokinetic/pharmaco-dynamic (PK/PD) and physiologically based pharmacokinetic (PBPK) modeling for whole-body dynamics. These methodologies play a crucial role in elucidating the complex mechanisms involved in the development of nanoparticle formulations and are essential in the creation of varied organic and inorganic systems for drug delivery. This review primarily concentrates on these computational simulation models and their significance in the context of nanoparticle-based drug delivery systems.
{"title":"Role of Computational Modeling in the Design and Development of Nanotechnology-based Drug Delivery Systems","authors":"Elsevar Mikayilov, Nizami Zeynalov, D. Taghiyev, Shamil Taghiyev","doi":"10.15255/cabeq.2024.2290","DOIUrl":"https://doi.org/10.15255/cabeq.2024.2290","url":null,"abstract":"Nanoparticle formulation development for drug delivery, a crucial aspect of nano-technology, encounters numerous challenges. These encompass selecting appropriate excipients, comprehending miscibility and solubility factors, ensuring efficient drug encapsulation and release, assessing stability, and facilitating drug transport in the bloodstream for accurate targeting and attachment. To address these intricate issues, a range of molecular computational models is utilized. These models include quantum mechanical simulations that handle the smallest particles and move through atomistic molecular dynamics for detailed molecular interactions, coarse-grained molecular dynamics (MD) for larger scale phenomena, and dissipative particle dynamics (DPD) for mesoscale modeling. Further scaling up, computational fluid dynamics (CFD) is used for fluidic behaviors, discrete element modeling for large particle systems, and both pharmacokinetic/pharmaco-dynamic (PK/PD) and physiologically based pharmacokinetic (PBPK) modeling for whole-body dynamics. These methodologies play a crucial role in elucidating the complex mechanisms involved in the development of nanoparticle formulations and are essential in the creation of varied organic and inorganic systems for drug delivery. This review primarily concentrates on these computational simulation models and their significance in the context of nanoparticle-based drug delivery systems.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.15255/cabeq.2022.2164
G. N. Devi, G. Sangavi, M. Chakravarthy, J. L. Sweetlin
Bitterness in citrus juice is a common quality issue in the fruit-based beverage industry. Naringin, the dominant flavonoid responsible for bitterness in citrus fruit juice, can be mitigated by the enzyme naringinase. This study focuses on the isolation of novel naringinase-producing bacterium from mandarin orange peel, followed by the production and partial purification of naringinase. The bacterial strain exhibiting the highest enzyme production potential was identified as Bacillus megaterium AULS 1. The effects of carbon source (naringin) concentration, inducer (naringenin), pH, and temperature on narin-ginase production were investigated. Optimized conditions yielded a maximum naringi-nase production of 386.43 U mL –1 . The produced enzyme was partially purified using ammonium sulfate precipitation and dialysis. The effects of pH, temperature, and metal ion concentration on the activity of the partially purified enzyme were evaluated, resulting in a highest activity of naringinase of 539.25 U mL –1 under optimized conditions. The debittering activity of the partially purified enzyme was 45.78 %. These findings demonstrate that Bacillus megaterium AULS 1 has the potential for naringinase production, and can be utilized for debittering citrus juices.
柑橘类果汁中的苦味是水果饮料行业中常见的质量问题。柚皮苷是造成柑橘果汁苦味的主要类黄酮，可以通过柚皮苷酶来减轻苦味。本研究的重点是从柑橘皮中分离出产柚皮苷酶的新型细菌，然后生产并部分纯化柚皮苷酶。研究了碳源（柚皮苷）浓度、诱导剂（柚皮苷）、pH 值和温度对柚皮苷酶生产的影响。优化条件下，柚皮苷酶的最大产量为 386.43 U mL -1 。利用硫酸铵沉淀和透析法对产生的酶进行了部分纯化。评估了 pH 值、温度和金属离子浓度对部分纯化酶活性的影响，结果表明在优化条件下，柚皮苷酶的最高活性为 539.25 U mL -1 。部分纯化酶的脱苦味活性为 45.78%。这些研究结果表明，巨型芽孢杆菌 AULS 1 具有生产柚皮苷酶的潜力，可用于柑橘汁脱苦味。
{"title":"Isolation, Production Optimization, and Purification of a Debittering Enzyme from Bacillus megaterium AULS 1","authors":"G. N. Devi, G. Sangavi, M. Chakravarthy, J. L. Sweetlin","doi":"10.15255/cabeq.2022.2164","DOIUrl":"https://doi.org/10.15255/cabeq.2022.2164","url":null,"abstract":"Bitterness in citrus juice is a common quality issue in the fruit-based beverage industry. Naringin, the dominant flavonoid responsible for bitterness in citrus fruit juice, can be mitigated by the enzyme naringinase. This study focuses on the isolation of novel naringinase-producing bacterium from mandarin orange peel, followed by the production and partial purification of naringinase. The bacterial strain exhibiting the highest enzyme production potential was identified as Bacillus megaterium AULS 1. The effects of carbon source (naringin) concentration, inducer (naringenin), pH, and temperature on narin-ginase production were investigated. Optimized conditions yielded a maximum naringi-nase production of 386.43 U mL –1 . The produced enzyme was partially purified using ammonium sulfate precipitation and dialysis. The effects of pH, temperature, and metal ion concentration on the activity of the partially purified enzyme were evaluated, resulting in a highest activity of naringinase of 539.25 U mL –1 under optimized conditions. The debittering activity of the partially purified enzyme was 45.78 %. These findings demonstrate that Bacillus megaterium AULS 1 has the potential for naringinase production, and can be utilized for debittering citrus juices.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.15255/cabeq.2023.2266
Hamid Reza Homayonfar, H. A. Ebrahim, M. Azarhoosh
This study consists of four main parts. First, a heterogeneous reactor model was developed to simulate a diesel hydrodesulfurization (HDS) reactor with catalyst deactivation. Second, operating conditions were investigated. Third, the simulation results from the first part were modeled using the response surface method and artificial neural networks (ANNs) to shorten the temperature path optimization time. Among the different modeling methods, the feed-forward ANN method employing the Bayesian Regularization (BR) training method with 10 neurons in the hidden layer demonstrated the highest accuracy. Finally, the temperature path of the trickle bed reactor was optimized. A three-dimensional curve depicting sulfur output content versus temperature and catalyst operation time was plotted using the most effective ANN approach as a fitness function. When the sulfur content met the Euro-6 requirement, the temperature path versus catalyst working period was optimized.
本研究包括四个主要部分。首先，开发了一个异相反应器模型，用于模拟催化剂失活的柴油加氢脱硫（HDS）反应器。其次，研究了运行条件。第三，利用响应面法和人工神经网络（ANN）对第一部分的模拟结果进行建模，以缩短温度路径优化时间。在不同的建模方法中，采用贝叶斯正则化（BR）训练方法的前馈式人工神经网络方法（隐层有 10 个神经元）精度最高。最后，对涓流床反应器的温度路径进行了优化。使用最有效的 ANN 方法作为拟合函数，绘制了硫含量与温度和催化剂运行时间的三维曲线。当硫含量达到欧 6 要求时，温度路径与催化剂工作时间的关系得到优化。
{"title":"Determining the Optimum Temperature Path Versus the Catalyst Working Time in a Trickle Bed Diesel Hydrodesulfurization Reactor","authors":"Hamid Reza Homayonfar, H. A. Ebrahim, M. Azarhoosh","doi":"10.15255/cabeq.2023.2266","DOIUrl":"https://doi.org/10.15255/cabeq.2023.2266","url":null,"abstract":"This study consists of four main parts. First, a heterogeneous reactor model was developed to simulate a diesel hydrodesulfurization (HDS) reactor with catalyst deactivation. Second, operating conditions were investigated. Third, the simulation results from the first part were modeled using the response surface method and artificial neural networks (ANNs) to shorten the temperature path optimization time. Among the different modeling methods, the feed-forward ANN method employing the Bayesian Regularization (BR) training method with 10 neurons in the hidden layer demonstrated the highest accuracy. Finally, the temperature path of the trickle bed reactor was optimized. A three-dimensional curve depicting sulfur output content versus temperature and catalyst operation time was plotted using the most effective ANN approach as a fitness function. When the sulfur content met the Euro-6 requirement, the temperature path versus catalyst working period was optimized.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.15255/cabeq.2023.2280
Hai D. Tran, Hua Nguyen Phuc, Phan Vu Hoang Phuong, Le Nguyen Phuc Thien, Tuan Loi Nguyen, Uyen P. N. Tran, Van-Han Dang
Dye pollutants, mainly discharged from the textile industry, have caused severe risks to human health and the ecosystem because of their toxicity, non-biodegradability
染料污染物主要来自纺织业，由于其毒性和不可生物降解性，对人类健康和生态系统造成了严重危害。
{"title":"A Proposed Model for Breakthrough Curves of Methylene Blue Adsorption on Biochar","authors":"Hai D. Tran, Hua Nguyen Phuc, Phan Vu Hoang Phuong, Le Nguyen Phuc Thien, Tuan Loi Nguyen, Uyen P. N. Tran, Van-Han Dang","doi":"10.15255/cabeq.2023.2280","DOIUrl":"https://doi.org/10.15255/cabeq.2023.2280","url":null,"abstract":"Dye pollutants, mainly discharged from the textile industry, have caused severe risks to human health and the ecosystem because of their toxicity, non-biodegradability","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.15255/cabeq.2024.2289
Adam Krupica, T. Jirout
A modified paddle mixer suitable for the homogenization of viscoplastic fluids and pastes, such as contemporary concrete mixtures, was developed to enhance homogeneity of the product, a crucial step in ensuring desired mechanical properties. In addition to the improvement in flow characteristics, this study presents the basic dimensionless characteristics in regression form, along with the measurement of the Metzner–Otto constant. These characteristics are essential for the use of the paddle mixer as an onsite rheometer, enabling rapid and straightforward evaluation of the desired rheological properties of the prepared mixture. The performance of the paddle mixer was assessed through homogenization experiments and power input measurements at various rotation speeds. The paddle mixer displayed creeping flow behavior up to a Re value of 50. The geometry of the paddle mixer was modified to achieve homogeneity throughout the volume, significantly influencing mixing mainly in the axial region of the mixer. To compensate for the non-Newtonian behavior, the Metzner–Otto approach was employed. Under creeping flow conditions and for pastes displaying flow index above 0.5, the paddle mixer can be characterized by a Metzner-Otto constant of 54.
{"title":"Paddle Mixer for Viscoplastic Materials and Pastes","authors":"Adam Krupica, T. Jirout","doi":"10.15255/cabeq.2024.2289","DOIUrl":"https://doi.org/10.15255/cabeq.2024.2289","url":null,"abstract":"A modified paddle mixer suitable for the homogenization of viscoplastic fluids and pastes, such as contemporary concrete mixtures, was developed to enhance homogeneity of the product, a crucial step in ensuring desired mechanical properties. In addition to the improvement in flow characteristics, this study presents the basic dimensionless characteristics in regression form, along with the measurement of the Metzner–Otto constant. These characteristics are essential for the use of the paddle mixer as an onsite rheometer, enabling rapid and straightforward evaluation of the desired rheological properties of the prepared mixture. The performance of the paddle mixer was assessed through homogenization experiments and power input measurements at various rotation speeds. The paddle mixer displayed creeping flow behavior up to a Re value of 50. The geometry of the paddle mixer was modified to achieve homogeneity throughout the volume, significantly influencing mixing mainly in the axial region of the mixer. To compensate for the non-Newtonian behavior, the Metzner–Otto approach was employed. Under creeping flow conditions and for pastes displaying flow index above 0.5, the paddle mixer can be characterized by a Metzner-Otto constant of 54.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.15255/cabeq.2023.2202
Nikola Šoltýsová, Ján Derco, Alexandra Horná
The kinetic study of the ozonation of atrazine as a single contaminant characterized as COD was studied. A jet loop ejector reactor was used to improve the mixing and transfer of ozone in the reaction system. The results show a higher efficiency of atrazine degradation in alkaline pH during the first 45 minutes. At the same time, the dechlorination of atrazine is faster than in neutral pH. Respirometric measurements carried out with activated sludge were used to evaluate the effect of atrazine and the ozonation intermediates on microorganisms’ oxygen uptake rate. The results showed that ozonation performed at an alkaline pH resulted in the formation of substances that are more rapidly biodegradable compared to substances formed by ozonation at neutral pH, as well as compared to atrazine.
{"title":"Kinetic Study of the Ozonation of Atrazine","authors":"Nikola Šoltýsová, Ján Derco, Alexandra Horná","doi":"10.15255/cabeq.2023.2202","DOIUrl":"https://doi.org/10.15255/cabeq.2023.2202","url":null,"abstract":"The kinetic study of the ozonation of atrazine as a single contaminant characterized as COD was studied. A jet loop ejector reactor was used to improve the mixing and transfer of ozone in the reaction system. The results show a higher efficiency of atrazine degradation in alkaline pH during the first 45 minutes. At the same time, the dechlorination of atrazine is faster than in neutral pH. Respirometric measurements carried out with activated sludge were used to evaluate the effect of atrazine and the ozonation intermediates on microorganisms’ oxygen uptake rate. The results showed that ozonation performed at an alkaline pH resulted in the formation of substances that are more rapidly biodegradable compared to substances formed by ozonation at neutral pH, as well as compared to atrazine.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.15255/cabeq.2023.2191
A. Bucić-Kojić, M. Planinić, Darijo Šibalić, M. Tišma
,
,
{"title":"Release of Fermentable Sugars from Corn Silage – The Effect of Biological Pretreatment","authors":"A. Bucić-Kojić, M. Planinić, Darijo Šibalić, M. Tišma","doi":"10.15255/cabeq.2023.2191","DOIUrl":"https://doi.org/10.15255/cabeq.2023.2191","url":null,"abstract":",","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139525860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-18DOI: 10.15255/cabeq.2022.2129
Jaturavit Pantakitcharoenkul, Matthew Y. Coblyn, Goran N. Jovanovic
Extracorporeal blood therapeutic devices (ETDs) are medical devices capable of performing treatments outside of the body through an extracorporeal circuit. These devices are widely used in both clinical/hospital settings and at-home care. A prototypical example is the treatment of nephrological diseases through hemodialysis and continuous renal replacement therapy using a hemodialyzer or an artificial kidney. The various applications of ETDs share common limitations such as coagulation, hemolysis, air embolism, and sensitivity reactions, all of which arise from the interactions of human physiology with the treatment mechanisms. Researchers are implementing microscale-based technology to achieve the next-generation ETD that can address persistent problems and improve therapeutic performance. This review article focuses on the evolution of the structure and development of conventional ETDs towards the miniaturization of the device. We begin with a narrow but common definition of ETDs as well as their current form and uses for renal replacement followed by a review of the importance and progression of microscale-based ETD development together with future directions towards achieving fully functional micro-scale-based ETDs that reflects contemporary technological and engineering advancements.
{"title":"Extracorporeal Blood Therapeutic Devices for Renal Replacement: A Review of Current Technologies and Future Directions Toward Microscale-based Devices","authors":"Jaturavit Pantakitcharoenkul, Matthew Y. Coblyn, Goran N. Jovanovic","doi":"10.15255/cabeq.2022.2129","DOIUrl":"https://doi.org/10.15255/cabeq.2022.2129","url":null,"abstract":"Extracorporeal blood therapeutic devices (ETDs) are medical devices capable of performing treatments outside of the body through an extracorporeal circuit. These devices are widely used in both clinical/hospital settings and at-home care. A prototypical example is the treatment of nephrological diseases through hemodialysis and continuous renal replacement therapy using a hemodialyzer or an artificial kidney. The various applications of ETDs share common limitations such as coagulation, hemolysis, air embolism, and sensitivity reactions, all of which arise from the interactions of human physiology with the treatment mechanisms. Researchers are implementing microscale-based technology to achieve the next-generation ETD that can address persistent problems and improve therapeutic performance. This review article focuses on the evolution of the structure and development of conventional ETDs towards the miniaturization of the device. We begin with a narrow but common definition of ETDs as well as their current form and uses for renal replacement followed by a review of the importance and progression of microscale-based ETD development together with future directions towards achieving fully functional micro-scale-based ETDs that reflects contemporary technological and engineering advancements.","PeriodicalId":9765,"journal":{"name":"Chemical and Biochemical Engineering Quarterly","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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